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    DIMERIZATION SWITCHES AND USES THEREOF
    2.
    发明申请
    DIMERIZATION SWITCHES AND USES THEREOF 审中-公开

    公开(公告)号：US20190054117A1

    公开(公告)日：2019-02-21

    申请号：US15536790

    申请日：2015-12-18

    申请人： Andreas Loew ,  Brian Edward Vash

    发明人： Andreas Loew ,  Brian Edward Vash

    IPC分类号： A61K35/17 ,  C12N15/62 ,  C12N9/12 ,  C12N9/90 ,  A61K48/00

    摘要： The present invention provides gene editing systems comprising gene editing dimerization switches comprising a first and second gene editing switch domain that allow for the regulation of a gene editing function by the introduction, e.g., administration, of a gene editing dimerization molecule having the ability to bring together a first gene editing switch domain and a second gene editing switch domain. A regulated gene editing function provides, e.g., less off-target side effects, and increases the therapeutic window. The present invention also provides improved FKBP/FRB-based dimerization switches wherein the FRB switch domain or the FKBP switch domain, or both the FRB and FKBP switch domains, comprise one or more mutations that optimize performance, e.g., that alter, e.g., enhance the formation of a complex between the first switch domain, the second switch domain, and the dimerization molecule, rapamycin, or a rapalog, e.g., RAD001.

    UNIVERSAL FIBRONECTIN TYPE III BOTTOM-SIDE BINDING DOMAIN LIBRARIES
    4.
    发明申请
    UNIVERSAL FIBRONECTIN TYPE III BOTTOM-SIDE BINDING DOMAIN LIBRARIES 有权
    通用FIBRONECTIN III型底端绑定域图书馆

    公开(公告)号：US20120208704A1

    公开(公告)日：2012-08-16

    申请号：US13504824

    申请日：2010-10-27

    申请人： Andreas Loew ,  Brian Edward Vash

    发明人： Andreas Loew ,  Brian Edward Vash

    IPC分类号： C40B40/10 ,  C40B40/02 ,  C40B30/04 ,  C40B10/00

    CPC分类号： C12N15/1037 ,  C12N15/1044 ,  C40B30/02 ,  C40B40/10 ,  C40B50/02 ,  G01N33/566 ,  G06F19/16

    摘要： The invention pertains to a natural-variant combinatorial library of fibronectin Type 3 domain (Fn3) polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity. The library polypeptides include (a) regions A, AB, B, C, CD, D, E, EF, F, and G having wildtype amino acid sequences of a selected native fibronectin Type 3 polypeptide or polypeptides, and (b) loop regions AB, CD, and EF having selected lengths (Bottom Loops). The Fn3 may also have loop regions BC, DE, and FG having wildtype amino acid sequences, having selected lengths, or mutagenized amino acid sequences (Top Loops).

    摘要翻译： 本发明涉及可用于筛选具有选定结合或酶活性的一种或多种多肽的存在的纤连蛋白3型结构域（Fn3）多肽的天然变体组合文库。 文库多肽包括（a）具有所选天然纤连蛋白3型多肽或多肽的野生型氨基酸序列的区域A，AB，B，C，CD，D，E，EF，F和G，和（b）环区 AB，CD和EF，具有选定的长度（底部循环）。 Fn3还可具有具有野生型氨基酸序列，具有选定长度或诱变氨基酸序列（Top Loops）的环区BC，DE和FG。

    Universal fibronectin type III bottom-side binding domain libraries
    5.
    发明授权
    Universal fibronectin type III bottom-side binding domain libraries 有权
    通用纤连蛋白III型底侧结合域文库

    公开(公告)号：US09139825B2

    公开(公告)日：2015-09-22

    申请号：US13504824

    申请日：2010-10-27

    申请人： Andreas Loew ,  Brian Edward Vash

    发明人： Andreas Loew ,  Brian Edward Vash

    IPC分类号： C40B40/10 ,  C12N15/10 ,  C40B30/02 ,  C40B50/02 ,  G06F19/16

    CPC分类号： C12N15/1037 ,  C12N15/1044 ,  C40B30/02 ,  C40B40/10 ,  C40B50/02 ,  G01N33/566 ,  G06F19/16

    摘要： The invention pertains to a natural-variant combinatorial library of fibronectin Type 3 domain (Fn3) polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity. The library polypeptides include (a) regions A, AB, B, C, CD, D, E, EF, F, and G having wildtype amino acid sequences of a selected native fibronectin Type 3 polypeptide or polypeptides, and (b) loop regions AB, CD, and EF having selected lengths (Bottom Loops). The Fn3 may also have loop regions BC, DE, and FG having wildtype amino acid sequences, having selected lengths, or mutagenized amino acid sequences (Top Loops).

    摘要翻译： 本发明涉及可用于筛选具有选定结合或酶活性的一种或多种多肽的存在的纤连蛋白3型结构域（Fn3）多肽的天然变体组合文库。 文库多肽包括（a）具有所选天然纤连蛋白3型多肽或多肽的野生型氨基酸序列的区域A，AB，B，C，CD，D，E，EF，F和G，和（b）环区 AB，CD和EF，具有选定的长度（底部循环）。 Fn3还可以具有具有野生型氨基酸序列，具有选定长度或诱变的氨基酸序列（Top Loops）的环区BC，DE和FG。