公开(公告)号：US20060287598A1

公开(公告)日：2006-12-21

申请号：US11158166

申请日：2005-06-20

申请人： Brian Lasater ,  Lee Mandell

发明人： Brian Lasater ,  Lee Mandell

IPC分类号： A61B8/00

CPC分类号： A61B17/22012 ,  A61B8/56 ,  A61B2017/22002 ,  A61F2/86 ,  A61F2002/30668 ,  A61F2250/0001

摘要： A system and method that minimizes plaque accumulation on a stent and thereby restenosis that could require a subsequent invasive medical procedure following implantation of the stent in a patient. A plurality of electrically-powered, biocompatible devices, implantable via injection, are positioned within the patient proximate to the stent and under control of a externally-placed controller are commanded to emit ultrasonic waves corresponding to the mechanical resonance of the stent. By controlling the frequency and the relative phases of the ultrasonic waves, the accumulation of plaque on the stent can thus be minimized.

摘要翻译： 一种系统和方法，其最小化支架上的斑块积聚，从而使得在患者植入支架后可能需要随后的侵入性医疗程序的再狭窄。 多个电动生物相容性装置，可植入通过注射，位于患者内靠近支架并且在外部放置的控制器的控制下被命令发射对应于支架的机械共振的超声波。 通过控制超声波的频率和相对相位，能够使支架上的斑块积聚最小化。

公开(公告)号：US20060287597A1

公开(公告)日：2006-12-21

申请号：US11157646

申请日：2005-06-20

申请人： Lee Mandell ,  Brian Lasater

发明人： Lee Mandell ,  Brian Lasater

IPC分类号： A61F2/06

CPC分类号： A61F2/86 ,  A61B17/22012 ,  A61B2017/22002 ,  A61F2250/0001

摘要： A system and method that minimizes plaque accumulation on a stent and thereby restenosis that could require a subsequent invasive medical procedure following stent implantation. The stent, essentially an expandable wire mesh tube comprised of a plurality of integral lattice portions, configured for expansion within a blood vessel of a patient, is formed with an electrically-controlled, biocompatible device as one of its integral lattice portions. In a first implementation, the biocompatible device is under control of an externally-positioned controller which causes the device to emit an ultrasonic wave at a frequency corresponding to the mechanical resonance of the stent and thereby minimize accumulation of plaque. In a second or supplemental implementation, the device is or other portions of the stent are coated with a drug that can be controllably eluted by passing a current through the coating under control of the biocompatible device and the externally-positioned controller.

摘要翻译： 一种使支架上的斑块积累最小化，从而使支架植入后可能需要随后的侵入性医疗程序的再狭窄的系统和方法。 支架，基本上是由多个整体网格部分组成的可扩展金属丝网，其构造成用于在患者的血管内扩张，该电极由电气控制的生物相容性装置形成为其整体网格部分之一。 在第一实施方案中，生物相容性装置在外部定位的控制器的控制下，其使得装置以对应于支架的机械共振的频率发射超声波，从而最小化斑块积聚。 在第二或补充实施方案中，所述装置是或支架的其它部分涂覆有可通过在生物相容性装置和外部定位的控制器的控制下使电流通过涂层而被可控制地洗脱的药物。

公开(公告)号：US20060118035A1

公开(公告)日：2006-06-08

申请号：US11340999

申请日：2006-01-27

申请人： Brian Lasater

发明人： Brian Lasater

IPC分类号： C30B1/00 ,  C30B5/00

CPC分类号： A61L27/10 ,  C03C4/0007 ,  C04B35/486 ,  C04B35/64 ,  C04B41/009 ,  C04B41/5042 ,  C04B41/87 ,  C04B2111/0025 ,  C04B2111/00836 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3225 ,  C04B2235/3229 ,  C04B2235/6587 ,  C04B2235/662 ,  C04B2235/765 ,  C04B2235/785 ,  Y10T428/12611 ,  Y10T428/12618 ,  C04B41/4545 ,  C04B41/4556 ,  C04B35/48

摘要： The invention is directed to a method of producing the material that is unaffected by the low-temperature degradation, humidity-enhanced phase transformation typical of yttria-stabilized zirconia in general, as well as of yttria-stabilized tetragonal zirconia polycrystalline ceramic (Y-TZP). Because of the high fracture toughness and high mechanical strength, this class of materials is widely used, including as implants, such as for the packaging material for small implantable neural-muscular sensors and stimulators. The destructive phase transformation is eliminated by converting the surface to stable cubic or T-prime zirconia by post-densification thermal treatment in a cation-rich milieu.

摘要翻译： 本发明涉及一种生产材料的方法，其不受通常的氧化钇稳定氧化锆的典型的低温降解，增湿相变以及氧化钇稳定的四方晶氧化锆多晶陶瓷（Y-TZP）的影响 ）。 由于高断裂韧性和高机械强度，这类材料被广泛使用，包括作为植入物，如用于小植入式神经 - 肌肉传感器和刺激物的包装材料。 通过在富含阳离子的环境中通过后致密化热处理将表面转化为稳定的立方或T形氧化锆来消除破坏性相变。

公开(公告)号：US20050266270A1

公开(公告)日：2005-12-01

申请号：US10853922

申请日：2004-05-25

申请人： Brian Lasater

发明人： Brian Lasater

IPC分类号： A61L27/10 ,  C03C4/00 ,  C04B35/48 ,  C04B35/486 ,  C04B41/50 ,  C04B41/87 ,  B32B9/00

CPC分类号： A61L27/10 ,  C03C4/0007 ,  C04B35/486 ,  C04B35/64 ,  C04B41/009 ,  C04B41/5042 ,  C04B41/87 ,  C04B2111/0025 ,  C04B2111/00836 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3225 ,  C04B2235/3229 ,  C04B2235/6587 ,  C04B2235/662 ,  C04B2235/765 ,  C04B2235/785 ,  Y10T428/12611 ,  Y10T428/12618 ,  C04B41/4545 ,  C04B41/4556 ,  C04B35/48

摘要： The invention is directed to a material and a method of producing the material that is unaffected by the low-temperature degradation, humidity-enhanced phase transformation typical of yttria-stabilized zirconia in general, as well as of yttria-stabilized tetragonal zirconia polycrystalline ceramic (Y-TZP). Because of the high fracture toughness and high mechanical strength, this class of materials is widely used, including as implants, such as for the packaging material for small implantable neural-muscular sensors and stimulators. The destructive phase transformation is eliminated by converting the surface to stable cubic or T-prime zirconia by post-densification thermal treatment in a cation-rich milieu.

摘要翻译： 本发明涉及一种材料和方法，该材料和方法不受通常的氧化钇稳定的氧化锆的典型的低温降解，增湿相变以及氧化钇稳定的四方晶氧化锆多晶陶瓷的影响（ Y-TZP）。 由于高断裂韧性和高机械强度，这类材料被广泛使用，包括作为植入物，如用于小植入式神经 - 肌肉传感器和刺激物的包装材料。 通过在富含阳离子的环境中通过后致密化热处理将表面转化为稳定的立方或T形氧化锆来消除破坏性相变。

公开(公告)号：US20050255380A1

公开(公告)日：2005-11-17

申请号：US11152443

申请日：2005-06-13

申请人： Brian Lasater ,  Joseph Schulman ,  Gary Schnittgrund

发明人： Brian Lasater ,  Joseph Schulman ,  Gary Schnittgrund

IPC分类号： C03C27/04 ,  H01J5/34 ,  H01M2/06 ,  H01M2/08 ,  H01M4/66 ,  H01M10/0525 ,  H01M10/36 ,  F16J15/10

CPC分类号： H01M10/0525 ,  C03C27/042 ,  H01J5/34 ,  H01M2/065 ,  H01M2/08 ,  H01M4/661 ,  H01M4/667 ,  Y10T29/4911 ,  Y10T29/49114

摘要： A hermetic seal that is compatible with lithium-ion electrolyte in lithium batteries is formed in feedthroughs by compression, chemical bonding, and mechanical bonding between the metal pin and a sealing glass, such as Cabal-12. The pin is alternately coated with a metal or a metal oxide to enhance compatibility with the lithium battery environment. The pin surface is deformed to enhance bonding with the glass seal. Mechanical bonds are also achieved by placing the pin/glass seal interface in compression by a compression bushing.

摘要翻译： 通过金属销和密封玻璃（例如Cabal-12）之间的压缩，化学键合和机械结合，在馈通中形成与锂电池中的锂离子电解质相容的气密密封。 引脚交替涂覆金属或金属氧化物，以增强与锂电池环境的兼容性。 销表面变形以增强与玻璃密封的粘合。 通过将销/玻璃密封接口通过压缩衬套压缩而实现机械结合。

公开(公告)号：US20070260294A1

公开(公告)日：2007-11-08

申请号：US11381979

申请日：2006-05-05

申请人： Joseph Schulman ,  Howard Stover ,  Brian Lasater

发明人： Joseph Schulman ,  Howard Stover ,  Brian Lasater

IPC分类号： A61N1/00

CPC分类号： A61N1/37229 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756

摘要： The invention is an antenna for use with an implantable microdevice, such as a microstimulator or microsensor, having a dipole antenna that is formed by ceramic processes on the inner or outer surface of the ceramic case of the microdevice. The antenna receives data transmitted from an external device, and transmits data to an external device. A dipole antenna may be formed from two radiating elements separated by an insulating material. A tuning circuit comprising capacitors and/or inductors is used to obtain resonance in the dipole antenna. In a preferred embodiment, the antenna is formed of a biocompatible material by applying a metal-containing paste to the ceramic case of the microdevice and thermally processing it.

摘要翻译： 本发明是一种与可植入微型装置（例如微型激励器或微型传感器）一起使用的天线，其具有通过微型器件的陶瓷壳体的内表面或外表面上的陶瓷工艺形成的偶极天线。 天线接收从外部设备发送的数据，并将数据发送到外部设备。 可以由由绝缘材料分离的两个辐射元件形成偶极天线。 使用包括电容器和/或电感器的调谐电路来获得偶极天线中的谐振。 在一个优选实施例中，天线由生物相容性材料形成，通过将金属的糊料涂敷到微型器件的陶瓷外壳上并进行热处理。