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1.发明授权公开(公告)号：US09435317B2
公开(公告)日：2016-09-06
申请号：US13635362
申请日：2011-06-23
CPC分类号： F03B13/20 , F05B2240/97 , Y02E10/38 , Y02E10/46
摘要： Wave energy conversion to produce electricity uses wave-engaging articulated, forward and after barges connected to a center inertial barge. A damper plate attached to the central barge minimizes heaving to increase stability. The barges use composite materials, steel or other materials that can withstand the impact and wear caused by a corrosive weather environment. A movable ballast weight in each barge adjusts the mass moment of inertia, and changes the natural pitching frequency. Electrical energy is generated from the motions of the barges and the movement of the movable ballast weights being converted by linear induction motor/generators and/or Pelton Wheel hydraulic systems connected to electrical generators. A dynamic computer control system controls the energy generating system to keep the forward/after barges and the movable ballast moving in phase with the wave excitation force. During dangerous wave action, the system is submerged and then re-surfaced when the waves have subsided.
摘要翻译： 波浪能量转换产生电力使用波动接合铰接，前进和后驳驳连接到中心惯性驳船。 安装在中央驳船上的阻尼板最大程度地降低了起伏以增加稳定性。 驳船使用复合材料，钢材或其他能够承受由腐蚀性天气环境造成的冲击和磨损的材料。 每个驳船中的可移动压载重物调节质量惯性矩，并改变自然俯仰频率。 电动能量是由驳船的运动产生的，运动中的可移动压舱重物由连续发电机的线性感应电机/发电机和/或Pelton Wheel液压系统转换。 动态计算机控制系统控制能量发生系统，以保持前方/后方的驳船和可动镇流器与波浪激发力同步运动。 在危险的波浪作用下，当海浪消退时，系统被淹没，然后重新浮出水面。
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2.发明授权Surface enhanced raman spectroscopy nanodome biosensors and methods of manufacturing the same 有权表面增强拉曼光谱纳米体系生物传感器及其制造方法公开(公告)号：US08953159B2
公开(公告)日：2015-02-10
申请号：US13438950
申请日：2012-04-04
CPC分类号： G02B1/005 , G01N21/658
摘要： Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring.
摘要翻译： 诸如透明塑料一次性管道或玻璃管的管道包括形成在管道中或放置在管道内的光子传感器。 光子传感器可以采用光子晶体传感器，分布式反馈激光传感器和表面增强拉曼光谱（SERS）传感器的形式，包括光子晶体增强型SERS传感器。 描述传感器的检测装置。 本发明具有许多应用，包括在医院护理中使用的管道（例如，导尿管，静脉输液管道，透析中使用的管，例如肝素管线或血管套件），食品制造，药物制造，水质监测和环境监测。
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3.发明授权Guided mode resonant filter biosensor using a linear grating surface structure 失效引导式谐振滤波器生物传感器采用线性光栅表面结构公开(公告)号：US07923239B2
公开(公告)日：2011-04-12
申请号：US12048560
申请日：2008-03-14
申请人： Brian T. Cunningham , Peter Li , Jean Qiu , Homer Pien
发明人： Brian T. Cunningham , Peter Li , Jean Qiu , Homer Pien
IPC分类号： G01N33/551
CPC分类号： G01N21/253 , B01L3/5085 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G02B5/1809 , Y10S435/808 , Y10S436/805 , Y10S436/813
摘要： Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
摘要翻译： 提供了用于检测生物分子相互作用的方法和组合物。 不需要使用标签，并且可以以高通量的方式执行方法。 本发明还提供用作窄带滤波器的光学装置。
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公开(公告)号：US20110080581A1
公开(公告)日：2011-04-07
申请号：US12900172
申请日：2010-10-07
CPC分类号： G01J3/12 , G01J3/02 , G01J3/0202 , G01J3/0275 , G01J3/0286 , G01J3/0289 , G01N21/35
摘要： Described herein are spectrometers comprising one or more wavelength-selective filters, such as guided mode resonance filters. Some of the spectrometers described herein are configured for obtaining absorbance spectra in a discrete fashion by measuring absorbances of a sample at multiple discrete wavelengths or wavelength bands. In another aspect, methods are also provided for obtaining spectra, images and chemical maps of samples in a discrete fashion.
摘要翻译： 这里描述的是包括一个或多个波长选择滤光器的光谱仪，例如导模谐振滤波器。 这里描述的一些光谱仪被配置为通过测量在多个离散波长或波长带上的样品的吸光度以离散的方式获得吸收光谱。 在另一方面，还提供了用于以离散方式获得样品的光谱，图像和化学图谱的方法。
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5.发明授权Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 失效光栅传感器结合无标签结合检测和荧光放大和传感器读出系统公开(公告)号：US07790406B2
公开(公告)日：2010-09-07
申请号：US11818742
申请日：2007-06-15
IPC分类号： G01N33/551
CPC分类号： G01N21/6452 , G01N21/648 , G01N21/76 , G01N21/7743 , G01N33/54373 , G01N33/6872 , Y10S436/805
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.
摘要翻译： 公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。 还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。 还公开了一种用于这种传感器的读出系统。 描述了用于生物传感器的各种应用，包括用于评估药物化合物对细胞功能的影响的基于细胞的测定。 还描述了针对两个不同波长的发光响应进行了优化的生物传感器实施例。 这种发光反应可以通过荧光（天然的或来自附着的荧光团），磷光，化学发光或其他发光技术产生。 两种不同的发光技术可以组合在相同的生物传感器芯片上。
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6.发明申请公开(公告)号：US20100202923A1
公开(公告)日：2010-08-12
申请号：US12799289
申请日：2010-04-20
CPC分类号： G01N21/6452 , G01N21/648 , G01N21/76 , G01N21/7743 , G01N33/54373 , G01N33/6872 , Y10S436/805
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.
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公开(公告)号：US07737392B2
公开(公告)日：2010-06-15
申请号：US12011093
申请日：2008-01-23
申请人： Brian T. Cunningham , Charles Choi
发明人： Brian T. Cunningham , Charles Choi
IPC分类号： H01L31/00
CPC分类号： G01N21/4133 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2300/0636 , B01L2300/0654 , B01L2300/0829 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , B82Y20/00 , G01N21/253 , G01N21/7743 , G02B2006/1213
摘要： Photonic crystal (PC) sensors, and sensor arrays and sensing systems incorporating PC sensors are described which have integrated fluid containment and/or fluid handling structures. The PC sensors are further integrated into a sample handling device such as a microwell plate. Sensors and sensing systems of the present disclosure are capable of high throughput sensing of analytes in fluid samples, bulk refractive index detection, and label-free detection of a range of molecules, including biomolecules and therapeutic candidates. The present disclosure also provides a commercially attractive fabrication platform for making photonic crystal sensors and systems wherein an integrated fluid containment structure and a photonic crystal structure are fabricated in a single molding or imprinting processing step amendable to high throughput processing.
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8.发明申请GRATING BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESNCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开基于光栅的传感器组合无线绑定检测和荧光灯放大和读取传感器系统公开(公告)号：US20100143959A1
公开(公告)日：2010-06-10
申请号：US12451724
申请日：2008-06-03
CPC分类号： G01N21/6452 , G01N21/648 , G01N21/76 , G01N21/7743 , G01N33/54373 , G01N33/6872 , Y10S436/805
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds, proteins, peptides and other materials on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.
摘要翻译： 公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。 还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。 还公开了一种用于这种传感器的读出系统。 描述了用于生物传感器的各种应用，包括用于评估药物化合物，蛋白质，肽和其他材料对细胞功能的影响的基于细胞的测定。 还描述了针对两个不同波长的发光响应进行了优化的生物传感器实施例。 这种发光反应可以通过荧光（天然的或来自附着的荧光团），磷光，化学发光或其他发光技术产生。 两种不同的发光技术可以组合在相同的生物传感器芯片上。
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公开(公告)号：US07622027B1
公开(公告)日：2009-11-24
申请号：US11214279
申请日：2005-08-29
申请人： Brian T. Cunningham
发明人： Brian T. Cunningham
IPC分类号： G01N27/453
CPC分类号： G01N27/453
摘要： The invention provides methods of detecting, purifying, quantifying, and separating molecules using an electrophoresis adapted biosensor.
摘要翻译： 本发明提供使用电泳适配生物传感器检测，纯化，定量和分离分子的方法。
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10.发明授权Method for producing a colorimetric resonant reflection biosensor on rigid surfaces 失效在刚性表面上制造比色共振反射生物传感器的方法公开(公告)号：US07615339B2
公开(公告)日：2009-11-10
申请号：US11485867
申请日：2006-07-13
申请人： Brian T. Cunningham , Jean Qiu
发明人： Brian T. Cunningham , Jean Qiu
IPC分类号： C12Q1/00
CPC分类号： B01L3/5085 , G01N21/253 , G01N21/4788 , G01N33/54373 , G02B5/1809 , Y10S435/808
摘要： The invention provides methods for fabricating calorimetric resonant reflection biosensors.
摘要翻译： 本发明提供了制造比色共振反射生物传感器的方法。
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