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公开(公告)号:US09273028B2
公开(公告)日:2016-03-01
申请号:US13882449
申请日:2011-10-28
申请人: Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
发明人: Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
IPC分类号: A01N43/00 , A61K31/00 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D487/04 , C07D519/00 , C07D473/34 , C07D513/04
CPC分类号: A61K31/553 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04 , C07D519/00
摘要: The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供可用作Tec家族激酶抑制剂的化合物,其组合物及其使用方法。
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2.Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners 失效
标题翻译: 抑制BCL蛋白与结合伙伴相互作用的化合物和方法公开(公告)号:US20130131063A1
公开(公告)日:2013-05-23
申请号:US13472136
申请日:2012-05-15
申请人: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号: C07D261/02 , C07D417/12 , A61K31/5377 , A61K31/454 , A61K31/496 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , C07D413/10 , C07D413/12 , A61K45/06
CPC分类号: C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译: 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病,例如癌症。
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公开(公告)号:US20120157443A1
公开(公告)日:2012-06-21
申请号:US13393192
申请日:2010-09-03
申请人: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号: A61K31/553 , C07D487/04 , A61K31/519 , C07D401/04 , A61K31/506 , C07D473/34 , A61K31/52 , C07D417/14 , C07D413/12 , C07D401/14 , A61K31/55 , A61P37/06 , A61P29/00 , A61P35/00 , A61P35/02 , C12N9/99
CPC分类号: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供了可用作Btk抑制剂的化合物,其组合物及其使用方法。
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公开(公告)号:US09029359B2
公开(公告)日:2015-05-12
申请号:US13393191
申请日:2010-09-03
申请人: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
发明人: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC分类号: C07D473/34 , C07D471/04 , C07D239/70 , C07D401/04 , C07D487/04
CPC分类号: C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
摘要: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供了可用作Btk抑制剂的化合物,其组合物及其使用方法。
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公开(公告)号:US08785440B2
公开(公告)日:2014-07-22
申请号:US13393192
申请日:2010-09-03
申请人: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号: A61K31/535
CPC分类号: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供了可用作Btk抑制剂的化合物,其组合物及其使用方法。
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公开(公告)号:US20130345192A1
公开(公告)日:2013-12-26
申请号:US13882449
申请日:2011-10-28
申请人: Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
发明人: Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
IPC分类号: C07D401/12 , C07D513/04 , C07D473/34 , C07D471/04 , C07D487/04
CPC分类号: A61K31/553 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04 , C07D519/00
摘要: The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供可用作Tec家族激酶抑制剂的化合物,其组合物及其使用方法。
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7.Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 失效
标题翻译: 抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号:US08461191B2
公开(公告)日:2013-06-11
申请号:US12956969
申请日:2010-11-30
申请人: Alfredo C. Castro , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Daniel A. Snyder , Thomas T. Tibbitts
发明人: Alfredo C. Castro , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号: A61K31/422 , C07D261/02
CPC分类号: C07D261/02 , C07D261/18 , C07D413/10 , C07D413/12 , C07D417/12 , C07D498/04
摘要: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译: 本发明的一个方面涉及结合bcl蛋白并抑制Bcl功能的杂环化合物。 本发明的另一方面涉及包含本发明的杂环化合物的组合物。 本发明提供了治疗和调节与过度增生相关的疾病如癌症的方法。
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公开(公告)号:US20120157442A1
公开(公告)日:2012-06-21
申请号:US13393191
申请日:2010-09-03
申请人: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
发明人: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC分类号: A61K31/553 , A61K31/519 , A61K31/5377 , C07D401/04 , A61K31/506 , A61P35/02 , A61K31/55 , C12N9/99 , A61P37/06 , A61P29/00 , A61P35/00 , C07D487/04 , C07D471/04
CPC分类号: C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
摘要: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译: 本发明提供了可用作Btk抑制剂的化合物,其组合物及其使用方法。
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9.Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 有权
标题翻译: 抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号:US08178690B2
公开(公告)日:2012-05-15
申请号:US13089530
申请日:2011-04-19
申请人: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence Blas Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号: C07D261/02 , A61K31/42
CPC分类号: C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译: 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病,例如癌症。
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10.Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners 有权
标题翻译: 抑制BCL蛋白与结合伙伴相互作用的化合物和方法公开(公告)号:US20110213145A1
公开(公告)日:2011-09-01
申请号:US13089530
申请日:2011-04-19
申请人: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
发明人: Alfredo C. Castro , Kristopher M. Depew , Michael J. Grogan , Charles W. Johannes , Edward B. Holson , Brian T. Hopkins , Gregg F. Keaney , Nii O. Koney , Tao Liu , David A. Mann , Marta Nevalainen , Stephane Peluso , Lawrence B. Perez , Daniel A. Snyder , Thomas T. Tibbitts
IPC分类号: C07D413/12 , C07D413/10 , C07D261/02 , C07D498/04
CPC分类号: C07D261/02 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要: The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译: 本发明涉及与bcl蛋白结合并抑制Bcl功能的含异唑烷的化合物。 该化合物可用于治疗和调节与过度增生相关的疾病,例如癌症。
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