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1.发明申请Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles 审中-公开用于含氮杂环的氟烷氧基苄基氨基衍生物的药物用途公开(公告)号：US20080132538A1
公开(公告)日：2008-06-05
申请号：US10911872
申请日：2004-08-05
IPC分类号： A61K31/439 , A61K31/445 , A61K31/4525 , A61P13/10
CPC分类号： A61K31/439 , A61K31/445 , A61K31/4525
摘要： A method of treating overactive bladder disorders characterized by involuntary neurogenic detrusor contractions associated with the pathology of multiple sclerosis by administering fluoroalkoxybenzylamino derivatives of nitrogen containing heterocyclic compounds, and specifically, by administering compounds of the formula wherein Q, X1, X2 and X3 are as defined below, and their pharmaceutically acceptable salts.
摘要翻译： 一种治疗膀胱过度活动症的方法，其特征在于通过施用含氮杂环化合物的氟烷氧基苄基氨基衍生物与多发性硬化症病理相关的非自愿神经源性逼尿肌收缩，特别是通过给药下式的化合物其中Q 1，X 1 >，X 2和X 3定义如下，及其药学上可接受的盐。
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公开(公告)号：US20130150376A1
公开(公告)日：2013-06-13
申请号：US13638642
申请日：2011-03-31
申请人： Michael Aaron Brodney , Ivan Viktorovich Efremov , Christopher John Helal , Brian Thomas O'Neill
发明人： Michael Aaron Brodney , Ivan Viktorovich Efremov , Christopher John Helal , Brian Thomas O'Neill
IPC分类号： C07D513/10 , A61K45/06 , A61K31/506 , A61K31/497 , A61K31/435 , A61K31/444
CPC分类号： C07D513/10 , A61K31/435 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有如说明书中定义的式I（I）的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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![Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds](/abs-image/US/2013/02/28/US20130053373A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130053373A1
公开(公告)日：2013-02-28
申请号：US13596208
申请日：2012-08-28
申请人： Michael Aaron BRODNEY , Christopher Ryan BUTLER , Christopher John HELAL , Brian Thomas O'NEILL
发明人： Michael Aaron BRODNEY , Christopher Ryan BUTLER , Christopher John HELAL , Brian Thomas O'NEILL
IPC分类号： C07D513/04 , A61P25/28 , A61K31/542
CPC分类号： C07D513/04
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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公开(公告)号：US07119207B2
公开(公告)日：2006-10-10
申请号：US09811218
申请日：2001-03-16
申请人： Brian Thomas O'Neill , Arthur Adam Nagel , John Michael Humphrey , Susan Beth Sobolov-Jaynes , Thomas Allen Chappie , Lawrence Albert Vincent , Eric Platt Arnold , Jianhua Huang
发明人： Brian Thomas O'Neill , Arthur Adam Nagel , John Michael Humphrey , Susan Beth Sobolov-Jaynes , Thomas Allen Chappie , Lawrence Albert Vincent , Eric Platt Arnold , Jianhua Huang
IPC分类号： C07D401/06 , C07D401/08 , A61K31/4523 , A61P25/06
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to certain benzoamide piperidine containing compounds and related compounds that exhibit activity as NK-1 receptor antagonists, (e.g., substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of central nervous system disorders, inflammatory disorders, cardiovascular disorders, ophthalmic disorders, gastrointestinal disorders, disorders caused by helicobacter pylori, disorders of the immune system, urinary incontinence, pain, migraine, emesis, angiogenesis and other disorders.
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公开(公告)号：US06881734B2
公开(公告)日：2005-04-19
申请号：US10833714
申请日：2004-04-27
IPC分类号： A61K31/551 , A61K45/00 , A61P1/04 , A61P3/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P21/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , C07D471/08 , C07D519/00
CPC分类号： C07D471/08
摘要： The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist.
摘要翻译： 本发明涉及一种通过向哺乳动物施用CNS-渗透剂α7烟碱受体激动剂来治疗哺乳动物（包括人）中枢神经系统（CNS）和其它疾病的疾病的方法。 它还涉及含有药学上可接受的载体和CNS渗透剂α7烟碱受体激动剂的药物组合物。
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![Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds](/abs-image/US/2015/03/26/US20150087637A1/abs.jpg.150x150.jpg)
公开(公告)号：US20150087637A1
公开(公告)日：2015-03-26
申请号：US14560190
申请日：2014-12-04
申请人： Michael Aaron Brodney , Christopher Ryan Butler , Christopher John Helal , Brian Thomas O'Neill
发明人： Michael Aaron Brodney , Christopher Ryan Butler , Christopher John Helal , Brian Thomas O'Neill
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中化合物具有如说明书中定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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![Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds](/abs-image/US/2015/01/13/US08933221B2/abs.jpg.150x150.jpg)
公开(公告)号：US08933221B2
公开(公告)日：2015-01-13
申请号：US13596208
申请日：2012-08-28
申请人： Michael Aaron Brodney , Christopher Ryan Butler , Christopher John Helal , Brian Thomas O'Neill
发明人： Michael Aaron Brodney , Christopher Ryan Butler , Christopher John Helal , Brian Thomas O'Neill
IPC分类号： C07D513/04 , A61K31/542 , A61P25/28
CPC分类号： C07D513/04
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中化合物具有如说明书中定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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8.发明申请公开(公告)号：US20090069287A1
公开(公告)日：2009-03-12
申请号：US12094175
申请日：2006-11-10
IPC分类号： A61K31/397 , C07D211/58 , A61K31/451 , C07D205/04 , A61K31/506 , C07D403/12
CPC分类号： C07D211/58 , C07D205/04 , C07D207/14 , C07D211/76 , C07D239/42 , C07D263/58 , C07D401/04 , C07D417/04
摘要： The invention relates to substituted azacycloalkaπe compounds useful in treating conditions of the Central Nervous System (CNS); a pharmaceutical composition comprising same; a method of treating such conditions and of treating conditions in which inhibition of beta-secretase is indicated.
摘要翻译： 本发明涉及可用于治疗中枢神经系统（CNS）病症的取代的氮杂环烷基化合物; 包含该组合物的药物组合物; 治疗这些病症的方法以及治疗其中表达β-分泌酶抑制的病症。
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公开(公告)号：US06809094B2
公开(公告)日：2004-10-26
申请号：US10229447
申请日：2002-08-28
IPC分类号： C07D47108
CPC分类号： C07D471/08
摘要： The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant &agr;7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant &agr;7 nicotinic receptor agonist.
摘要翻译： 本发明涉及一种通过向哺乳动物施用CNS-渗透剂α7烟碱受体激动剂来治疗哺乳动物（包括人）中枢神经系统（CNS）和其它疾病的疾病的方法。 它还涉及含有药学上可接受的载体和CNS渗透剂α7烟碱受体激动剂的药物组合物。
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![Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds](/abs-image/US/2017/01/24/US09550795B2/abs.jpg.150x150.jpg)
公开(公告)号：US09550795B2
公开(公告)日：2017-01-24
申请号：US14560190
申请日：2014-12-04
申请人： Michael Aaron Brodney , Christopher Ryan Butler , Christopher John Helal , Brian Thomas O'Neill
发明人： Michael Aaron Brodney , Christopher Ryan Butler , Christopher John Helal , Brian Thomas O'Neill
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中化合物具有如说明书中定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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