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公开(公告)号：US06771730B1
公开(公告)日：2004-08-03
申请号：US09856966
申请日：2001-09-06
IPC分类号： G01T300
CPC分类号： G01T3/08
摘要： A boron carbide solid state neutron detector and method of using the detector is disclosed, wherein the detector includes a layer of boron carbide wherein the boron carbide layer is an electrically active part of the detection device, a sensing mechanism inherent to said boron carbide layer, wherein the sensing mechanism detects changes in the boron carbide layer caused by the interception of neutrons and a monitoring device coupled to the sensing mechanics.
摘要翻译： 公开了一种使用该检测器的碳化硼固态中子检测器和方法，其中该检测器包括一碳化硼层，其中该碳化硼层为该检测装置的电活性部分，该碳化硼层为固有的感测机构， 其中感测机构检测由截取中子引起的碳化硼层的变化以及耦合到感测机构的监测装置。
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公开(公告)号：US5037751A
公开(公告)日：1991-08-06
申请号：US405553
申请日：1989-09-11
申请人： Mauro A. Bertola , Arthur F. Marx , Hein S. Koger , Wilhelmus J. Quax , Cornelis J. van der Laken , Gareth T. Phillips , Brian W. Robertson , Peter D. Watts
发明人： Mauro A. Bertola , Arthur F. Marx , Hein S. Koger , Wilhelmus J. Quax , Cornelis J. van der Laken , Gareth T. Phillips , Brian W. Robertson , Peter D. Watts
IPC分类号： C12N15/09 , A61K31/19 , A61K31/33 , A61P25/04 , A61P29/00 , C07C57/30 , C07D209/46 , C07H21/04 , C12N1/20 , C12N1/21 , C12N9/18 , C12N15/00 , C12P7/40 , C12P17/00 , C12P41/00 , C12R1/06 , C12R1/10 , C12R1/125 , C12R1/19 , C12R1/38 , C12R1/385 , C12R1/39 , C12R1/40 , C12R1/465 , C12R1/785
CPC分类号： C12P41/005 , C12N9/18 , C12P17/00 , C12P7/40 , Y10S435/822 , Y10S435/83 , Y10S435/836 , Y10S435/839 , Y10S435/849 , Y10S435/874 , Y10S435/886
摘要： A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula ##STR1## or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R.sub.1 represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula ##STR2## wherein R.sub.2 is an ester residue and preferably an alkyl group optionally substituted, to the action of a micro-organism having the ability for stereoselective hydrolysis of compound (II) into compound (I), having at least 80% by weight the S-configuration, and if desired converting compound (I) into the pharmaceutically acceptable salt or ester thereof.
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公开(公告)号：US5586714A
公开(公告)日：1996-12-24
申请号：US319014
申请日：1994-10-06
CPC分类号： B23K26/123 , C04B37/021 , C04B2235/6565 , C04B2235/6567 , C04B2237/40 , C04B2237/405 , C04B2237/407 , C04B2237/408 , C04B2237/54 , C04B2237/567
摘要： A method of bonding metal to a non-metal substrate. The process includes placing the metal in contact with a non-metal substrate and blanketing the contact region with a gaseous atmosphere in which the amount of reactive gas is limited to minimize oxidation of the metal at the surface. Heating of the metal is accomplished by various means including a laser beam. The metal is heated to a point where the reactive gas and metal form a eutectic that wets the contact area between the metal and non-metallic substrate. Upon cooling, the metal and non-metallic substrate are bonded together over a substantial part of the contact area.
摘要翻译： 将金属键合到非金属基底的方法。 该方法包括使金属与非金属基底接触并且用气态气氛覆盖接触区域，其中活性气体的量被限制以最小化表面处金属的氧化。 通过包括激光束的各种装置来实现金属的加热。 将金属加热到反应气体和金属形成浸渍金属和非金属基底之间的接触面积的共晶体的点。 在冷却时，金属和非金属基底在接触区域的大部分上粘合在一起。
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4.发明授权Process for producing 4-(2-methoxyethyl)-phenyl-glycidyl ether and/or metoprolol 失效制备4-（2-甲氧基乙基） - 苯基 - 缩水甘油醚和/或美托洛尔的方法
公开(公告)号：US4956284A
公开(公告)日：1990-09-11
申请号：US826791
申请日：1986-02-06
申请人： Gareth T. Phillips , Brian W. Robertson , Mauro A. Bertola , Hein S. Koger , Arthur F. Marx , Peter D. Watts
发明人： Gareth T. Phillips , Brian W. Robertson , Mauro A. Bertola , Hein S. Koger , Arthur F. Marx , Peter D. Watts
IPC分类号： C07C213/04 , C07D303/24 , C12P17/02
CPC分类号： C07C213/04 , C07D303/24 , C12P17/02 , Y10S435/863 , Y10S435/872 , Y10S435/874
摘要： A process for the preparation of metoprolol in a stereospecific form or a non-toxic, pharmaceutically acceptable acid addition salt thereof and/or a stereospecific form of 4-(2-methoxyethyl)-phenyl glycidyl ether which comprises subjecting 4-(2-methoxyethyl)-phenyl allyl ether to the action of a microorganism having the ability for stereoselective epoxidation of 4-(2-methoxyethyl)-phenyl allyl ether into 4-(2-methoxyethyl)-phenyl glycidyl ether having at least 80% by weight the S configuration, at least partly separating 4-(2-methoxyethyl)-phenyl glycidyl ether and/or reacting 4-(2-methoxyethyl)-phenyl glycidyl ether with isopropylamine and at least partly separating metoprolol and/or converting metoprolol into its non-toxic, pharmaceutically acceptable acid addition salt.
摘要翻译： 以立体特异性形式或无毒的药学上可接受的酸加成盐和/或立体特异性形式的4-（2-甲氧基乙基） - 苯基缩水甘油醚制备美托洛尔的方法，其包括使4-（2-甲氧基乙基） （4-甲氧基乙基） - 苯基烯丙基醚的4-（2-甲氧基乙基） - 苯基缩水甘油醚的立体选择性环氧化反应能力的微生物的作用，其具有至少80重量％的S 至少部分分离4-（2-甲氧基乙基） - 苯基缩水甘油醚和/或使4-（2-甲氧基乙基） - 苯基缩水甘油醚与异丙胺反应，并至少部分分离美托洛尔和/或将美托洛尔转化为无毒的 ，药学上可接受的酸加成盐。
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公开(公告)号：US4696901A
公开(公告)日：1987-09-29
申请号：US558749
申请日：1983-12-07
摘要： Hydrocarbon utilizing microorganisms are immobilized on a plastic carrier in an aqueous nutrient medium to which a minor amount of a water-immiscible hydrocarbon substrate has been added. The water-immiscible hydrocarbon is preferably hexadecane or dodecylcyclohexane and the plastic carrier is preferably polytetrafluoroethylene. Presence of the water-immiscible hydrocarbon substrate results in increased loading of microorganisms on the carrier.
摘要翻译： 利用微生物的碳氢化合物固定在塑料载体上的水性营养培养基中，少量的与水不混溶的烃基质已加入到其中。 与水不混溶的烃优选为十六烷或十二烷基环己烷，塑料载体优选为聚四氟乙烯。 与水不混溶的烃基质的存在导致载体上微生物的负载增加。
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6.发明授权Process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula 失效用于制备具有下式的立体特异性形式的药学活性化合物的方法
公开(公告)号：US4886750A
公开(公告)日：1989-12-12
申请号：US674
申请日：1987-01-06
申请人： Mauro A. Bertola , Arthur F. Marx , Hein S. Koger , Wilhelmus J. Quax , Cornelis J. Van der Laken , Gareth T. Phillips , Brian W. Robertson , Peter D. Watts
发明人： Mauro A. Bertola , Arthur F. Marx , Hein S. Koger , Wilhelmus J. Quax , Cornelis J. Van der Laken , Gareth T. Phillips , Brian W. Robertson , Peter D. Watts
IPC分类号： C12N15/09 , A61K31/19 , A61K31/33 , A61P25/04 , A61P29/00 , C07C57/30 , C07D209/46 , C07H21/04 , C12N1/20 , C12N1/21 , C12N9/18 , C12N15/00 , C12P7/40 , C12P17/00 , C12P41/00 , C12R1/06 , C12R1/10 , C12R1/125 , C12R1/19 , C12R1/38 , C12R1/385 , C12R1/39 , C12R1/40 , C12R1/465 , C12R1/785
CPC分类号： C12P41/005 , C12N9/18 , C12P17/00 , C12P7/40 , Y10S435/822 , Y10S435/83 , Y10S435/836 , Y10S435/839 , Y10S435/849 , Y10S435/874 , Y10S435/886
摘要： A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula ##STR1## or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R.sub.1 represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula ##STR2## wherein R.sub.1 is an ester residue and preferably an alkyl group optionally substituted, to the action of a micro-organism having the ability for stereoselective hydrolysis of compound (II) into compound (I), having at least 80% by weight the S-configuration, and if desired converting compound (I) into the pharmaceutically acceptable salt or ester thereof.
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