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37 条记录 (耗时 0.019 秒)

    Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same
    1.
    发明申请
    Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same 有权
    苯并噻吩-2-羰基胍衍生物及其制备方法和含有它们的药物组合物

    公开(公告)号：US20100004466A1

    公开(公告)日：2010-01-07

    申请号：US11794238

    申请日：2005-12-27

    申请人： Kyu Yang Yi ,  SunKyung Lee ,  Jee Hee Suh ,  Nak Jeong Kim ,  Hyunsuk Lee ,  Byung-Ho Lee ,  Sung-eun Yoo ,  Kyung-Hee Lee ,  Yong Oh Lee

    发明人： Kyu Yang Yi ,  SunKyung Lee ,  Jee Hee Suh ,  Nak Jeong Kim ,  Hyunsuk Lee ,  Byung-Ho Lee ,  Sung-eun Yoo ,  Kyung-Hee Lee ,  Yong Oh Lee

    IPC分类号： C07D333/54

    CPC分类号： C07D333/70

    摘要： The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.

    摘要翻译： 本发明涉及苯并噻吩-2-羰基胍衍生物，其制备方法和含有它们的药物组合物。 该衍生物对钠/氢交换器NHE-1具有有效的抑制作用，改善了分离缺血心脏模型缺血/再灌注诱导的心脏损伤的功能恢复，并显着降低了体内缺血动物模型中的心肌梗死面积，从而显示 良好的心脏保护作用。 此外，衍生物保护神经元细胞和脑，如通过其对来自坏死和凋亡的神经元细胞的保护作用以及通过其在体内缺血性脑模型中显着降低脑梗塞大小的能力所证明的。 该衍生物可以有效地用于预防和治疗心肌梗塞，心律失常，心绞痛等缺血性心脏病，脑血管疾病如脑卒中，并用作心脏保护剂，用于接受再灌注治疗的患者，包括化学药剂 作为溶栓剂，或手术如冠状动脉旁路和经皮腔内冠状动脉成形术。

    Wireless receiver for receiving multi-contents file and method for outputting data using the same
    2.
    发明授权
    Wireless receiver for receiving multi-contents file and method for outputting data using the same 有权
    用于接收多内容文件的无线接收器及使用其的数据输出方法

    公开(公告)号：US07519686B2

    公开(公告)日：2009-04-14

    申请号：US10448054

    申请日：2003-05-30

    申请人： Ji-Hoon Hong ,  Byung-Ho Lee ,  Chun-Yong Oh

    发明人： Ji-Hoon Hong ,  Byung-Ho Lee ,  Chun-Yong Oh

    IPC分类号： G06F13/00

    CPC分类号： H04N7/163 ,  G01C21/26 ,  G01S5/0009 ,  H04L29/06027 ,  H04L65/602 ,  H04L65/607 ,  H04N21/4113 ,  H04N21/43615 ,  H04N21/43637 ,  H04N21/440236 ,  H04N21/4438 ,  H04W4/00 ,  H04W84/12 ,  H04W88/02

    摘要： A wireless receiver for receiving a multi-contents file and a method for outputting data using the same, which can receive, navigation information for providing intuitively recognizable search interfaces to a user by radio in real time, receive various types of contents files by radio in real time, and output the received information and files through an AV device. A video decoder decodes a video stream on the basis of an MPEG standard. An audio decoder decodes an audio contents file. An OSD processor processes a text file and additional information. A video output unit selectively configures decoded video data and text data on one screen and performs encoding and outputting operations based on the format of a display unit. An audio output unit outputs decoded audio data. A user interface receives a user's command. A WLAN card communicates WLAN data with a computer system. A controller requests the computer system to transmit navigation screen information, at least one contents file or additional information of the contents file edited and processed by the computer system, analyzes a data stream received by radio from the computer system responsive to the request, and performs a control operation so that a result of the analysis is inputted into the decoder or OSD processor. A memory stores the stream and control program data.

    摘要翻译： 一种用于接收多内容文件的无线接收器和用于输出数据的方法，其可以通过无线电实时地接收用于向用户提供直观可识别的搜索接口的导航信息，通过无线电接收各种类型的内容文件 并通过AV设备输出收到的信息和文件。 视频解码器基于MPEG标准解码视频流。 音频解码器解码音频内容文件。 OSD处理器处理文本文件和附加信息。 视频输出单元在一个屏幕上选择性地配置解码的视频数据和文本数据，并且基于显示单元的格式执行编码和输出操作。 音频输出单元输出解码音频数据。 用户界面接收用户的命令。 WLAN卡与计算机系统通信WLAN数据。 控制器请求计算机系统发送导航屏幕信息，由计算机系统编辑和处理的至少一个内容文件或内容文件的附加信息，响应于该请求，从计算机系统分析由无线电接收的数据流，并执行 使得分析结果被输入到解码器或OSD处理器的控制操作。 存储器存储流和控制程序数据。

    Lightweight Silicone Implant and Manufacturing Method Thereof
    3.
    发明申请
    Lightweight Silicone Implant and Manufacturing Method Thereof 审中-公开
    轻质硅胶植入物及其制造方法

    公开(公告)号：US20080215149A1

    公开(公告)日：2008-09-04

    申请号：US11848120

    申请日：2007-08-30

    申请人： Eun Hyun Bae ,  Byung Ho Lee

    发明人： Eun Hyun Bae ,  Byung Ho Lee

    IPC分类号： A61F2/02

    CPC分类号： A61F2/12 ,  A61F2/0059 ,  A61F2/02

    摘要： Disclosed herein are a lightweight silicone implant which is manufactured by filling a foamed silicone sponge and/or vacant silicone capsules in a silicone bag or a cohesive gel bag and sealing the bag, and a method for manufacturing the same.

    摘要翻译： 本文公开了一种轻质硅树脂植入物，其通过在硅树脂袋或粘性凝胶袋中填充泡沫硅氧烷海绵和/或空的硅酮胶囊并密封袋而制造，及其制造方法。

    Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them
    4.
    发明授权
    Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them 失效
    呋喃羰基胍衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：US07351843B2

    公开(公告)日：2008-04-01

    申请号：US10581799

    申请日：2004-12-24

    申请人： Kyu Yang Yi ,  Sun Kyung Lee ,  Nak Jeong Kim ,  Jee Hee Suh ,  Soon Hee Hwang ,  Byung Ho Lee ,  Ho Won Seo ,  Sun Kyung Hwang ,  Sung Eun Yoo ,  Kyung Hee Lee

    发明人： Kyu Yang Yi ,  Sun Kyung Lee ,  Nak Jeong Kim ,  Jee Hee Suh ,  Soon Hee Hwang ,  Byung Ho Lee ,  Ho Won Seo ,  Sun Kyung Hwang ,  Sung Eun Yoo ,  Kyung Hee Lee

    IPC分类号： C07D307/02 ,  A61K31/34 ,  A01N43/08

    CPC分类号： C07D307/68

    摘要： The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same.Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.

    摘要翻译： 本发明涉及呋喃羰基胍衍生物，其制备方法和包含其的药物组合物。 本发明的呋喃羰基胍衍生物抑制NHE-1（钠氢交换异构体1），其有助于恢复从缺血/再灌注损伤的心脏功能，并降低心肌梗死率，表明它们对心肌细胞具有保护作用。 因此，本发明的呋喃羰基胍衍生物可以有效地用于预防和治疗心肌梗死，心律失常，心绞痛等缺血性心脏病，也是应用于再灌注治疗的心脏保护剂的有希望的候选物，包括溶栓剂 或心脏手术，包括冠状动脉旁路移植术，经皮腔内冠状动脉血管成形术等

    Imidazole derivatives and processes for the preparation thereof
    6.
    发明授权
    Imidazole derivatives and processes for the preparation thereof 失效
    咪唑衍生物及其制备方法

    公开(公告)号：US5665738A

    公开(公告)日：1997-09-09

    申请号：US737563

    申请日：1996-11-13

    申请人： Sung-Eun Yoo ,  Kyu-Yang Yi ,  Sang-Hee Lee ,  Hye-Ryung Kim ,  Jee-Hee Suh ,  Nak-Jeong Kim ,  Seon-Ju Kim ,  Ok-Ja Cha ,  Young-Ah Shin ,  Wha-Sup Shin ,  Sung-Hou Lee ,  Yi-Sook Jung ,  Byung-Ho Lee ,  Ho-Won Seo ,  Hye-Suk Lee

    发明人： Sung-Eun Yoo ,  Kyu-Yang Yi ,  Sang-Hee Lee ,  Hye-Ryung Kim ,  Jee-Hee Suh ,  Nak-Jeong Kim ,  Seon-Ju Kim ,  Ok-Ja Cha ,  Young-Ah Shin ,  Wha-Sup Shin ,  Sung-Hou Lee ,  Yi-Sook Jung ,  Byung-Ho Lee ,  Ho-Won Seo ,  Hye-Suk Lee

    IPC分类号： A61K31/44 ,  A61K31/4427 ,  A61P9/12 ,  A61P43/00 ,  C07D401/14 ,  A61K31/415 ,  C07D403/14

    CPC分类号： C07D401/14

    摘要： Novel imidazole derivatives of formula(I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity: ##STR1## wherein: A is a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl group, or OR.sub.1 wherein R.sub.1 is a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical; B is a halogen, CF.sub.3 or CF.sub.2 CF.sub.3 ; X is N or N-oxide; Y is --CH.sub.2 --, --CH(OR.sub.1)-- wherein R.sub.1 is the same as defined above, or --C(.dbd.O)--; n is 0 or an integer of 1 to 4; Z is a halogen, --OH, --OR.sub.1, --NR.sub.1 R.sub.2, --N(.dbd.O)R.sub.3 R.sub.4, --C(.dbd.O)R.sub.1, --C(.dbd.O)OR.sub.1, --CH(OR.sub.1).sub.2 or --C(.dbd.O)N.sub.1 N.sub.2 wherein R.sub.1 is the same as defined above, R.sub.2 is, independently of R.sub.1, a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical, and R.sub.3 and R.sub.4 are independently a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical; and D is a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical.

    摘要翻译： PCT No.PCT / KR95 / 00058 Sec。 371日期：1996年11月13日 102（e）1996年11月13日PCT PCT 1995年5月19日PCT公布。 公开号WO95 / 32198 日期：1995年11月30日公式（I）的新型咪唑衍生物有效抑制血管紧张素II的作用并具有优异的抗高血压活性：其中：A是直链，支链或环状的C 1 -C 6烷基，或 OR1，其中R1是氢或直链，支链或环状的C1-C6烷基; B是卤素，CF 3或CF 2 CF 3; X是N或N-氧化物; Y是-CH 2 - ， - CH（OR 1） - ，其中R 1与上述定义相同，或-C（= O） - ; n为0或1〜4的整数， Z是卤素，-OH，-OR1，-NR1R2，-N（= O）R3R4，-C（= O）R1，-C（= O）OR1，-CH（OR1）2或-C ）N1N2其中R1与上述定义相同，R2独立地为R1，氢或直链，支链或环状的C1-C6烷基，R3和R4独立地为直链，支链或环状的C 1 -C 6烷基 激进; 并且D是氢或直链，支链或环状的C 1 -C 6烷基。

    Hydraulic circuit to prevent bucket separation from bucket rest during traveling of heavy equipment
    8.
    发明申请
    Hydraulic circuit to prevent bucket separation from bucket rest during traveling of heavy equipment 有权
    液压回路，用于在重型设备行驶期间防止铲斗与斗环分离

    公开(公告)号：US20080229738A1

    公开(公告)日：2008-09-25

    申请号：US12075590

    申请日：2008-03-12

    申请人： Byung Ho Lee

    发明人： Byung Ho Lee

    IPC分类号： F15B13/01

    CPC分类号： E02F9/2239 ,  F15B2211/20576 ,  F15B2211/30505 ,  F15B2211/3116 ,  F15B2211/329 ,  F15B2211/40515 ,  F15B2211/41518 ,  F15B2211/41554 ,  F15B2211/428 ,  F15B2211/45 ,  F15B2211/7142 ,  F15B2211/781

    摘要： A hydraulic circuit is provided, which can prevent the bucket from being separated from the bucket rest by preventing a change of stroke of a boom cylinder or an arm cylinder during long traveling of wheel type heavy equipment, and can secure safety since it is not required for an operator to adjust the position of a working device like boom and arm. The hydraulic circuit includes first and second hydraulic pumps, a boom cylinder, an arm cylinder, a boom confluence logic valve, a first port formed to connect with a large chamber of the boom cylinder in a housing in which a spool for the boom cylinder is shiftably installed, a second port formed to connect with a hydraulic tank in the housing, and a first orifice formed between the housing and a land part of the spool for the boom cylinder located between the first port and the second port. During long traveling of the heavy equipment, a very small amount of hydraulic fluid fed from the second hydraulic pump to the large chamber of the boom cylinder drains to the hydraulic tank through the first orifice to prevent a change of stroke of the boom cylinder.

    摘要翻译： 提供了一种液压回路，其可以通过在轮式重型设备的长时间行驶期间防止动臂缸或手臂缸的行程改变来防止铲斗与斗架分离，并且可以确保安全性，因为不需要 用于操作者调节工作装置如吊杆和手臂的位置。 液压回路包括第一和第二液压泵，动臂缸，臂缸，悬臂汇流逻辑阀，形成为与动臂缸的大腔连接的壳体中的第一端口，其中用于动臂缸的阀芯为 可移动地安装有形成为与壳体中的液压箱连接的第二端口，以及形成在壳体和位于第一端口和第二端口之间的动臂缸的线轴的陆部的第一孔口。 在重型设备的长时间行进中，从第二液压泵供给到动臂缸的大腔的非常少量的液压流体通过第一孔排入液压缸，以防止动臂缸的行程改变。

    Surgical cast cutter
    10.
    发明授权
    Surgical cast cutter 失效
    手术切割机

    公开(公告)号：US06558394B2

    公开(公告)日：2003-05-06

    申请号：US09823742

    申请日：2001-03-30

    申请人： Byung-Ho Lee

    发明人： Byung-Ho Lee

    IPC分类号： A61F504

    CPC分类号： A61F15/02 ,  A61F13/04

    摘要： A surgical cast cutter for removing orthopedic bandages of a hard casting material type comprises a first shank (2a), cutting portion (2b), and second shank (2c); a first housing (1) having a built-in rotating device which rotates the cutting tool; a tool holding device which rotatably holds the cutting tool (2); a second housing (15) which receives the cutting tool (2) and having an integrated horseshoe-shaped protrusion which is inserted between the hard cover and affected area as a guide such that the hard cover may be easily cut; and a hood (50) which is coupled to the second housing (15) and movable in the up and down direction. The hood also serves as a collecting device for collecting dusts and debris formed from the removal of the cast. A method is also disclosed for applying the cast on an affected area such that it may be easily removed by the cast cutter.

    摘要翻译： 一种用于去除硬质铸造材料类型的矫形绷带的外科用铸造刀具，包括第一柄（2a），切割部分（2b）和第二柄（2c）; 具有使所述切削工具旋转的内置旋转装置的第一壳体（1） 可旋转地保持切割工具（2）的工具保持装置; 第二壳体（15），其容纳所述切割工具（2）并且具有整体的马蹄形突起，所述马蹄形突起插入在所述硬盖和所述受影响区域之间作为引导件，使得所述硬盖可以容易地切割; 以及联接到第二壳体（15）并可沿上下方向移动的罩（50）。 发动机盖还用作收集从收集铸件中形成的灰尘和碎屑的收集装置。 还公开了一种将铸件施加在受影响区域上的方法，使得其可以被铸造切割器容易地移除。