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公开(公告)号：US20250025443A1
公开(公告)日：2025-01-23
申请号：US18700786
申请日：2022-10-13
Applicant: CLEAR CREEK BIO, INC.
Inventor： John K. DICKSON , Joseph P. VACCA , Maryline KIENLE , Nadim SHOHDY , James Francis DEMAREST
IPC: A61K31/397 , A61K31/166 , A61K31/277 , A61K31/337 , A61K31/36 , A61K31/381 , A61K31/4025 , A61K31/4045 , A61K31/407 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/426 , A61K31/428 , A61K31/4412 , A61K31/4439 , A61K31/4465 , A61K31/4709 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P31/14 , C07C233/65 , C07C243/32 , C07C255/44 , C07C271/16 , C07C311/08 , C07D205/04 , C07D207/20 , C07D209/32 , C07D211/46 , C07D213/74 , C07D215/22 , C07D223/04 , C07D231/18 , C07D231/56 , C07D235/08 , C07D235/26 , C07D239/34 , C07D241/44 , C07D245/02 , C07D277/34 , C07D277/64 , C07D295/073 , C07D305/08 , C07D317/54 , C07D333/20 , C07D333/54 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D411/14 , C07D413/04 , C07D413/06 , C07D413/14 , C07D471/04 , C07D471/08 , C07D487/04
Abstract: This invention provides compounds for the inhibition of papain-like proteases (PLpros) for the inhibition of viruses, including compounds of formula (I″), and pharmaceutically acceptable salts thereof.
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公开(公告)号：US12012383B2
公开(公告)日：2024-06-18
申请号：US17553637
申请日：2021-12-16
Applicant: Clear Creek Bio, Inc.
Inventor： Vikram S. Kumar , David P. Hesson , Ping Huang , Mo Jia , Xianjun You
IPC: C07D215/52
CPC classification number: C07D215/52
Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2′-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
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公开(公告)号：US20220177435A1
公开(公告)日：2022-06-09
申请号：US17553637
申请日：2021-12-16
Applicant: Clear Creek Bio, Inc.
Inventor： Vikram S. Kumar , David P. Hesson , Ping Huang , Mo Jia , Xianjun You
IPC: C07D215/52
Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2′-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
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公开(公告)号：US20210115493A1
公开(公告)日：2021-04-22
申请号：US17068914
申请日：2020-10-13
Applicant: Clear Creek Bio, Inc.
Inventor： David P. Hesson , Barbara Powers , Vikram S. Kumar
Abstract: The invention provides methods for adjusting a drug dosing regimen, including a drug dosage and schedule of administration, in individuals who have previously received at least one dose of the drug. Adjustments to the dosage and/or schedule are made based on measured levels of the drug or metabolite of the drug and a biomarker of engagement of the drug with its target. The methods are useful for administration of therapeutic agents, such as brequinar, that alter metabolic pathways.
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公开(公告)号：US20210087146A1
公开(公告)日：2021-03-25
申请号：US17111701
申请日：2020-12-04
Applicant: Clear Creek Bio, Inc.
Inventor： Vikram S. Kumar , David P. Hesson , Ping Huang , Mo Jia , Xianjun You
IPC: C07D215/52
Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2′-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
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公开(公告)号：US20210315880A1
公开(公告)日：2021-10-14
申请号：US17207504
申请日：2021-03-19
Applicant: Clear Creek Bio, Inc.
Inventor： Vikram S. Kumar , David P. Hesson , Andrew D. Levin
Abstract: The invention provided methods of treating viral infections, such as COVID-19, by providing an agent that inhibits a nucleotide synthesis pathway. In certain methods, the agent is an inhibitor of dihydroorotate dehydrogenase, such as a brequinar. In certain methods, brequinar is provided to a subject according to a dosing regimen that tailors levels of the drug in the lungs to achieve optimal therapeutic benefit. The dosing regimen may include defined levels of brequinar administered to the subject or defined levels of brequinar attained the lungs of the subject. The invention also provides combination therapies in which an inhibitor of dihydroorotate dehydrogenase is provided together with a second therapeutic agent.
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7.发明申请
公开(公告)号：US20210300873A1
公开(公告)日：2021-09-30
申请号：US17207516
申请日：2021-03-19
Applicant: Clear Creek Bio, Inc.
Inventor： Abdolsamad Tadayon , Ping Huang , Chaoyi Deng , Jinsuo Yang , Siyi Jiang , Qingqing Lu , Lin Cui , Mo Jia , Xianjun You , David P. Hesson
IPC: C07D215/52 , A61K9/00
Abstract: The invention provides compositions containing a stable crystalline form of brequinar and methods of making such composition. The invention also provides methods of using such compositions to treat a condition in a subject.
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公开(公告)号：US20210154186A1
公开(公告)日：2021-05-27
申请号：US17166187
申请日：2021-02-03
Applicant: Clear Creek Bio, Inc.
Inventor： Vikram S. Kumar , David P. Hesson
Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2′-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
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公开(公告)号：US20190292154A1
公开(公告)日：2019-09-26
申请号：US16364446
申请日：2019-03-26
Applicant: Clear Creek Bio, Inc.
Inventor： Vikram S. Kumar , David P. Hesson , Ping Huang , Mo Jia , Xianjun You
IPC: C07D215/52
Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2′-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
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公开(公告)号：US20190290634A1
公开(公告)日：2019-09-26
申请号：US16364431
申请日：2019-03-26
Applicant: Clear Creek Bio, Inc.
Inventor： Vikram S. Kumar , David P. Hesson
Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2′-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.
