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    Facilitation of repair of neural injury with CM101/GBS toxin
    1.
    发明授权
    Facilitation of repair of neural injury with CM101/GBS toxin 失效
    促进CM101 / GBS毒素修复神经损伤

    公开(公告)号：US06476001B1

    公开(公告)日：2002-11-05

    申请号：US09364620

    申请日：1999-07-29

    申请人： Carl G. Hellerqvist ,  Artur W. Wamil ,  Barbara D. Wamil

    发明人： Carl G. Hellerqvist ,  Artur W. Wamil ,  Barbara D. Wamil

    IPC分类号： A01N4304

    CPC分类号： A61K38/164

    摘要： Neural injury may be advantageously treated with CM101, a polysaccharide toxin isolated from Group B &bgr;-hemolytic Streptococcus bacteria. CM1O1 treatment aids in the re-establishment of neuronal connectivity, at least partially inhibits scar formation, and increases the probability of survival during the critical period following injury to the central nervous system. Preexisting neural injuries having scar tissue are ameliorated by surgical excision of the scar tissue in conjunction with administration of CM101.

    摘要翻译： CM101可以有利地治疗神经损伤，CM101是从B型溶血性链球菌细菌分离的多糖毒素。 CM1O1治疗有助于重建神经元连通性，至少部分抑制瘢痕形成，并增加在中枢神经系统损伤后的关键时期的生存概率。 通过手术切除瘢痕组织与CM101的给药一起改善了具有瘢痕组织的预先存在的神经损伤。

    Polysaccharide toxin from group B -62 hemolytic streptococcus (GBS) having improved purity
    2.
    发明授权
    Polysaccharide toxin from group B -62 hemolytic streptococcus (GBS) having improved purity 失效
    来自B-62溶血性链球菌（GBS）的多糖毒素具有改善的纯度

    公开(公告)号：US6136789A

    公开(公告)日：2000-10-24

    申请号：US44583

    申请日：1998-03-19

    申请人： Carl G. Hellerqvist

    发明人： Carl G. Hellerqvist

    IPC分类号： C08B37/00 ,  C12P1/04 ,  C12P19/26 ,  A01N43/04 ,  C12N1/20 ,  C07J3/00 ,  A23J1/00

    CPC分类号： C12P19/26 ,  C12P1/04

    摘要： A method for purifying a polysaccharide from group B .beta.-hemolytic Streptococcus (GBS) bacteria includes contacting a bacterial fermentation stock with a hydrophobic interaction chromatography (HIC) resin. Additional steps may include a phenol/saline extraction and an ion exchange chromatography. The method results in a product having very high purity. The product of the purification provides a composition which is useful in both research and therapeutic settings.

    摘要翻译： 从B组β-溶血性链球菌（GBS）细菌中纯化多糖的方法包括使细菌发酵原料与疏水相互作用层析（HIC）树脂接触。 附加步骤可以包括苯酚/盐水萃取和离子交换层析。 该方法产生具有非常高纯度的产物。 纯化的产物提供了一种在研究和治疗环境中有用的组合物。

    GBS TOXIN RECEPTOR
    7.
    发明申请
    GBS TOXIN RECEPTOR 审中-公开
    GBS毒素受体

    公开(公告)号：US20100076184A1

    公开(公告)日：2010-03-25

    申请号：US12142060

    申请日：2008-06-19

    申请人： Carl G. Hellerqvist ,  Changlin Fu

    发明人： Carl G. Hellerqvist ,  Changlin Fu

    IPC分类号： C07H21/04

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： A novel GBS toxin receptor, and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides are provided as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides and polypeptides.

    摘要翻译： 提供了一种新型的GBS毒素受体及其制备和使用方法。 提供GBS毒素受体多核苷酸和多肽以及涉及这种多核苷酸和多肽的检测，筛选和治疗方法以及药物组合物。

    GBS Toxin Receptor Compositions and Methods of Use
    8.
    发明申请
    GBS Toxin Receptor Compositions and Methods of Use 审中-公开
    GBS毒素受体组合物和使用方法

    公开(公告)号：US20090221804A1

    公开(公告)日：2009-09-03

    申请号：US12331067

    申请日：2008-12-09

    申请人： Carl G. Hellerqvist ,  Changlin Fu

    发明人： Carl G. Hellerqvist ,  Changlin Fu

    IPC分类号： C07K16/28

    CPC分类号： A61K39/0011

    摘要： Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors.

    摘要翻译： 提供了通过施用至少一种GBS毒素受体多肽或其至少一种免疫原性片段来预防或减弱病原体病症的方法。 还提供了包含GBS毒素受体多肽的组合物和制备这种组合物的方法。 在本发明的另一个实施方案中，免疫动物还接受GBS毒素，与GBS毒素受体的免疫相容抗体和/或扩增的自体T细胞至GBS毒素受体。 本发明还包括鉴定另外的GBS毒素受体的方法。

    GBS toxin receptor
    9.
    发明授权
    GBS toxin receptor 有权
    GBS毒素受体

    公开(公告)号：US06803448B1

    公开(公告)日：2004-10-12

    申请号：US09359167

    申请日：1999-07-21

    申请人： Carl G. Hellerqvist ,  Changlin Fu

    发明人： Carl G. Hellerqvist ,  Changlin Fu

    IPC分类号： C07K1400

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： A novel GBS toxin receptor, and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides are provided as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides and polypeptides.

    摘要翻译： 提供了一种新型的GBS毒素受体及其制备和使用方法。 提供GBS毒素受体多核苷酸和多肽以及涉及这种多核苷酸和多肽的检测，筛选和治疗方法以及药物组合物。

    Polysaccharide toxin from Group B .beta.-hemolytic Streptococcus (GBS) having improved purity
    10.
    发明授权
    Polysaccharide toxin from Group B .beta.-hemolytic Streptococcus (GBS) having improved purity 失效
    来自B族β-溶血性链球菌（GBS）的多糖毒素具有改善的纯度

    公开(公告)号：US5811403A

    公开(公告)日：1998-09-22

    申请号：US744770

    申请日：1996-09-30

    申请人： Carl G. Hellerqvist

    发明人： Carl G. Hellerqvist

    IPC分类号： C08B37/00 ,  C12P1/04 ,  C12P19/26 ,  A01N43/04 ,  C12P21/04 ,  C12N1/20 ,  A23J1/00

    CPC分类号： C12P19/26 ,  C12P1/04

    摘要： The invention relates to a polysaccharide toxin from group B .beta.-hemolytic Streptococcus (GBS) having improved purity. The improved purity of the toxin, 95%, is achieved by the method of purification wherein a bacterial fermentation stock is subjected to chromatography with hydrophobic interaction chromatography (HIC) resin, extraction with a phenol/saline solution followed by ion exchange chromatography. The purified GBS toxin has a molecular weight of about 300 kD and a relative carbohydrate ratio of rhamnose:mannose:galactose:glucose:N-acetyl glucosamine:N-acetyl galactosamine of about 0:1:3:1:1:1, respectively. The GBS toxin is useful for treatment of tumors and other medical conditions.

    摘要翻译： 本发明涉及具有改善的纯度的B组β-溶血性链球菌（GBS）的多糖毒素。 通过纯化方法实现了95％的毒素的纯度提高，其中细菌发酵原料用疏水相互作用色谱（HIC）树脂进行色谱分离，用苯酚/盐水溶液萃取，然后进行离子交换层析。 纯化的GBS毒素的分子量约为300kD，鼠李糖：甘露糖：半乳糖：葡萄糖：N-乙酰葡糖胺：N-乙酰半乳糖胺的相对碳水化合物比例分别为约0：1：3：1：1：1 。 GBS毒素可用于治疗肿瘤和其他医疗条件。