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    Inhibitors of C-FMS kinase
    1.
    发明授权
    Inhibitors of C-FMS kinase 有权
    C-FMS激酶抑制剂

    公开(公告)号：US07973035B2

    公开(公告)日：2011-07-05

    申请号：US12139876

    申请日：2008-06-16

    申请人： Carl R. Illig ,  Shelley K. Ballentine ,  Jinsheng Chen ,  Renee Louise DesJarlais ,  Sanath K. Meegalla ,  Mark Wall ,  Kenneth Wilson

    发明人： Carl R. Illig ,  Shelley K. Ballentine ,  Jinsheng Chen ,  Renee Louise DesJarlais ,  Sanath K. Meegalla ,  Mark Wall ,  Kenneth Wilson

    IPC分类号： A61K31/54 ,  A61K31/505 ,  C07D285/16 ,  C07D239/02

    CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

    摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

    摘要翻译： 本发明涉及式I化合物：其中Z，X，J，R 2和W在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-型的溶剂化物，水合物，互变异构体和药学上可接受的盐， fms激酶。 治疗自身免疫性疾病的方法 和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，前列腺癌，肺癌，结肠癌，胃癌，毛细胞白血病的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 骨质疏松症，佩吉特氏病和其他疾病，其中骨吸收介导包括类风湿性关节炎和其它形式的炎症性关节炎，骨关节炎，假体衰竭，溶骨性肉瘤，骨髓瘤和肿瘤转移至骨骼的发病率与式I化合物， 也提供。

    Inhibitors of C-FMS Kinase
    3.
    发明申请
    Inhibitors of C-FMS Kinase 有权
    C-FMS激酶抑制剂

    公开(公告)号：US20080275031A1

    公开(公告)日：2008-11-06

    申请号：US12139876

    申请日：2008-06-16

    申请人： Carl R. Illig ,  Shelley K. Ballentine ,  Jinsheng Chen ,  Renee Louise DesJarlais ,  Sanath K. Meegalla ,  Mark Wall ,  Kenneth Wilson

    发明人： Carl R. Illig ,  Shelley K. Ballentine ,  Jinsheng Chen ,  Renee Louise DesJarlais ,  Sanath K. Meegalla ,  Mark Wall ,  Kenneth Wilson

    IPC分类号： A61K31/549 ,  C07D401/12 ,  C07D285/16 ,  A61K31/506 ,  A61P35/00 ,  A61P25/00 ,  A61P37/00 ,  A61P35/04 ,  A61P9/00 ,  A61P29/00 ,  C07D239/04 ,  A61K31/454

    CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

    摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

    摘要翻译： 本发明涉及式I化合物：其中Z，X，J，R 2和W在本说明书中列出，以及溶剂合物，水合物，互变异构体及其药学上可接受的盐，其中 抑制蛋白酪氨酸激酶，特别是c-fms激酶。 治疗自身免疫性疾病的方法 和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，前列腺癌，肺癌，结肠癌，胃癌，毛细胞白血病的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 骨质疏松症，佩吉特氏病和其他疾病，其中骨吸收介导包括类风湿性关节炎和其它形式的炎症性关节炎，骨关节炎，假体衰竭，溶骨性肉瘤，骨髓瘤和肿瘤转移至骨骼的发病率与式I化合物， 也提供。

    Inhibitors of c-fms kinase
    4.
    发明授权
    Inhibitors of c-fms kinase 有权
    c-fms激酶抑制剂

    公开(公告)号：US07414050B2

    公开(公告)日：2008-08-19

    申请号：US11736617

    申请日：2007-04-18

    申请人： Carl R. Illig ,  Shelly K. Ballentine ,  Jinsheng Chen ,  Renee Louise DesJarlais ,  Sanath K. Meegalla ,  Mark Wall ,  Kenneth Wilson

    发明人： Carl R. Illig ,  Shelly K. Ballentine ,  Jinsheng Chen ,  Renee Louise DesJarlais ,  Sanath K. Meegalla ,  Mark Wall ,  Kenneth Wilson

    IPC分类号： C07D417/04 ,  C07D417/14 ,  A61K31/541

    CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

    摘要： The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

    摘要翻译： 本发明涉及式I化合物：其中Z，X，J，R 2和W在本说明书中列出，以及溶剂合物，水合物，互变异构体及其药学上可接受的盐，其中 抑制蛋白酪氨酸激酶，特别是c-fms激酶。 治疗自身免疫性疾病的方法 和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，前列腺癌，肺癌，结肠癌，胃癌，毛细胞白血病的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 骨质疏松症，佩吉特氏病和其他疾病，其中骨吸收介导包括类风湿性关节炎和其它形式的炎症性关节炎，骨关节炎，假体衰竭，溶骨性肉瘤，骨髓瘤和肿瘤转移至骨骼的发病率与式I化合物， 也提供。

    Compositions of iodoaniline derivatives and cellulose derivatives for visualization of the gastrointestinal tract
    9.
    发明授权
    Compositions of iodoaniline derivatives and cellulose derivatives for visualization of the gastrointestinal tract 失效
    用于可视化胃肠道的碘苯胺衍生物和纤维素衍生物的组合物

    公开(公告)号：US5422114A

    公开(公告)日：1995-06-06

    申请号：US201731

    申请日：1994-02-25

    申请人： Carl R. Illig ,  Thomas J. Caulfield ,  Robert W. Lee ,  Edward J. Baker

    发明人： Carl R. Illig ,  Thomas J. Caulfield ,  Robert W. Lee ,  Edward J. Baker

    IPC分类号： A61K9/107 ,  A61K49/04 ,  C08K5/315 ,  C08L101/00 ,  C08L101/06 ,  G01N21/00

    CPC分类号： A61K49/0404 ,  A61K49/0409 ,  A61K49/0461

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract, whereinZ is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R.sub.1 and R.sub.2 are independently H, C.sub.1 -C.sub.25 alkyl, cycloalkyl, acetyl or halo-lower-alkyl, wherein said C.sub.1 -C.sub.25 alkyl, cycloalkyl and halo lower-alkyl are optionally substituted with fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy and said acetyl is optionally substituted with fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;n is 1-4;y is 1-4; andx is 1 or 2in a pharmaceutically acceptable carrier comprising a cellulose derivative.

    摘要翻译： 公开了用于胃肠道口服或逆行检查的x射线造影剂组合物，其包含下式的x射线产生剂或其药学上可接受的盐及其用于胃肠道诊断放射学的方法，其中Z 是H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; R 1和R 2独立地为H，C 1 -C 25烷基，环烷基，乙酰基或卤代低级烷基，其中所述C 1 -C 25烷基，环烷基和卤代低级烷基任选被氟 - 低级 - 烷基，芳基，低级 - 烷氧基 ，羟基，羧基，低级烷氧基羰基或低级烷氧基 - 羰氧基，所述乙酰基任选被氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，低级 - 烷氧基羰基或低级 - 烷氧基 - 羰氧基取代; n为1-4; y为1-4; 并且在包含纤维素衍生物的药学上可接受的载体中x为1或2。