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公开(公告)号:US20080166723A1
公开(公告)日:2008-07-10
申请号:US11878749
申请日:2007-07-26
申请人: Jeroen Aerssens , Maria Athanasiou , Carlos Brain , Nadine Cohen , Bradley Dain , R. Rex Denton , Richard S. Judson , Vural Ozdemir , Carol R. Reed
发明人: Jeroen Aerssens , Maria Athanasiou , Carlos Brain , Nadine Cohen , Bradley Dain , R. Rex Denton , Richard S. Judson , Vural Ozdemir , Carol R. Reed
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要: Haplotypes in the CDK5 gene associated with cognitive response to galantamine treatment are disclosed. Compositions and methods for detecting and using these CDK5 haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising galantamine or derivatives thereof that are approved for treating patients having one of these CDK5 haplotypes, methods and kits for predicting the response of an individual to galantamine based upon his/her haplotype profile, and methods for treating Alzheimer's patients based upon their haplotype profile.
摘要翻译: 公开了与加兰他敏治疗的认知反应相关的CDK5基因中的单倍型。 公开了用于在各种临床应用中检测和使用这些CDK5单倍型的组合物和方法。 这样的应用包括制剂,其包含被批准用于治疗患有这些CDK5单倍型之一的患者的加兰他敏或其衍生物,用于根据他/她的单倍型分布预测个体对加兰他敏的反应的方法和试剂盒,以及治疗阿尔茨海默病患者的方法 基于它们的单倍型分布。
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公开(公告)号:US07250258B2
公开(公告)日:2007-07-31
申请号:US11005029
申请日:2004-12-07
申请人: Jeroen Aerssens , Maria Athanasiou , Carlos Brain , Nadine Cohen , Bradley Dain , R. Rex Denton , Richard S. Judson , Vural Ozdemir , Carol R. Reed
发明人: Jeroen Aerssens , Maria Athanasiou , Carlos Brain , Nadine Cohen , Bradley Dain , R. Rex Denton , Richard S. Judson , Vural Ozdemir , Carol R. Reed
CPC分类号: C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要: Haplotypes in the CDK5 gene associated with cognitive response to galantamine treatment are disclosed. Compositions and methods for detecting and using these CDK5 haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising galantamine or derivatives thereof that are approved for treating patients having one of these CDK5 haplotypes, methods and kits for predicting the response of an individual to galantamine based upon his/her haplotype profile, and methods for treating Alzheimer's patients based upon their haplotype profile.
摘要翻译: 公开了与加兰他敏治疗的认知反应相关的CDK5基因中的单倍型。 公开了用于在各种临床应用中检测和使用这些CDK5单倍型的组合物和方法。 这样的应用包括制剂,其包含被批准用于治疗患有这些CDK5单倍型之一的患者的加兰他敏或其衍生物,用于根据他/她的单倍型分布预测个体对加兰他敏的反应的方法和试剂盒,以及治疗阿尔茨海默氏病患者的方法 基于它们的单倍型分布。
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