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1.发明授权公开(公告)号：US08354387B2
公开(公告)日：2013-01-15
申请号：US12390913
申请日：2009-02-23
IPC分类号： C12N15/11
CPC分类号： A61K47/64
摘要： Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.
摘要翻译： 包含SEQ ID NO：1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2的肽载体和合适的siRNA的复合物，其中R 1表示任何氨基酸残基，更优选K或S，R 2为空或表示以下基团之一：半胱胺，半胱氨酸，硫醇，酰胺， 线性或分枝的任选取代的C1-C6烷基，伯胺或仲胺，奥昔克酸衍生物，脂质，磷脂或胆固醇，并且选择所述siRNA使靶mRNA沉默。
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2.发明申请公开(公告)号：US20090258926A1
公开(公告)日：2009-10-15
申请号：US12390913
申请日：2009-02-23
IPC分类号： A61K31/713
CPC分类号： A61K47/64
摘要： Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.
摘要翻译： 包含SEQ ID NO：1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2的肽载体和合适的siRNA的复合物，其中R 1表示任何氨基酸残基，更优选K或S，R 2为空或表示以下基团之一：半胱胺，半胱氨酸，硫醇，酰胺， 线性或分枝的任选取代的C1-C6烷基，伯胺或仲胺，奥昔克酸衍生物，脂质，磷脂或胆固醇，并且选择所述siRNA使靶mRNA沉默。
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公开(公告)号：US09376468B2
公开(公告)日：2016-06-28
申请号：US14009648
申请日：2012-04-04
IPC分类号： C07K7/08 , A61K31/713 , A61K47/48 , C12N15/11
CPC分类号： C12N15/113 , A61K31/337 , A61K31/409 , A61K31/704 , A61K31/7072 , A61K31/7105 , A61K31/713 , A61K47/48038 , A61K47/48046 , A61K47/48215 , A61K47/48246 , A61K47/48884 , A61K47/542 , A61K47/543 , A61K47/60 , A61K47/64 , A61K47/6929 , C07K7/08 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/3513 , C12N2320/32
摘要： The présent invention relates to cell-penetrating peptides char-acterized in that it comprises an amino acid séquence selected in the group consisting of X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8, X1LX2LARWX9LX3X9X4LWX9LX5X6X7X8 and X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8, wherein X1 is beta-A or S, X2 is F or W, X3 is L, W, C or I, X4 is S, A, N or T, Xs is L or W, X6 is W or R, X7 is K or R, X8 is A or none, and X9 is R or S. Thèse peptides exhibit high efficiency, low toxicity and a natural tropism for lung tissues, and can be used either in simple complex with the cargo to be vectorised, or in nanoparticles comprising two layers of cell-penetrating peptides around the cargo.
摘要翻译： 本发明涉及细胞穿透肽，其特征在于其包含在由X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8，X1LX2LARWX9XXXXXXXXXXXXLLX5X6X7X8和X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8组成的组中选择的氨基酸选择性，其中X1为β-A或S，X2为F或W，X3为L ，W，C或I，X4为S，A，N或T，X为L或W，X6为W或R，X7为K或R，X8为A或无，X9为R或S. 表现出高效率，低毒性和肺组织的自然向性，并且可以与要载体的货物的简单复合物或者包含在货物周围的两层细胞穿透肽的纳米颗粒中使用。
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4.发明授权Nozzle device used for multiphase fluid flow simulation in high temperature and pressurized mixing reactors 失效用于高温和加压混合反应器中的多相流体流动模拟的喷嘴装置公开(公告)号：US07665886B2
公开(公告)日：2010-02-23
申请号：US11344735
申请日：2006-02-02
IPC分类号： B01F7/16
CPC分类号： B01F7/00541 , B01F7/00158 , B01F7/18
摘要： A mixing apparatus has a chamber, a shaft extending into the chamber, a motor drivingly interconnected to the shaft, a nozzle support affixed to the shaft and extending outwardly therefrom within the chamber, and a nozzle having an interior passageway affixed to the nozzle support such that the nozzle moves in the chamber as the motor drivingly rotates the shaft. The chamber has a multi-phase fluid therein. The nozzle moves through the fluid such that fluid is channeled through the interior passageway at a same rate that the nozzle moves through the fluid. Another nozzle can be affixed to the nozzle support diametrically opposite to the nozzle.
摘要翻译： 混合装置具有腔室，延伸到腔室中的轴，驱动地连接到轴的马达，固定到轴上并从腔室内向外延伸的喷嘴支撑件，以及具有固定到喷嘴支撑件上的内部通道的喷嘴 当马达驱动地转动轴时，喷嘴在腔室中移动。 该室内具有多相流体。 喷嘴移动通过流体，使得流体以与喷嘴移动通过流体的速率相同的速率通过内部通道。 另一个喷嘴可以固定在与喷嘴直径相对的喷嘴支架上。
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5.发明申请Nozzle device used for multiphase fluid flow simulation in high temperature and pressurized mixing reactors 失效用于高温和加压混合反应器中的多相流体流动模拟的喷嘴装置公开(公告)号：US20070217286A1
公开(公告)日：2007-09-20
申请号：US11344735
申请日：2006-02-02
申请人： Joseph Morris , Catherine Morris
发明人： Joseph Morris , Catherine Morris
IPC分类号： B01F7/16
CPC分类号： B01F7/00541 , B01F7/00158 , B01F7/18
摘要： A mixing apparatus has a chamber, a shaft extending into the chamber, a motor drivingly interconnected to the shaft, a nozzle support affixed to the shaft and extending outwardly therefrom within the chamber, and a nozzle having an interior passageway affixed to the nozzle support such that the nozzle moves in the chamber as the motor drivingly rotates the shaft. The chamber has a multi-phase fluid therein. The nozzle moves through the fluid such that fluid is channeled through the interior passageway at a same rate that the nozzle moves through the fluid. Another nozzle can be affixed to the nozzle support diametrically opposite to the nozzle.
摘要翻译： 混合装置具有腔室，延伸到腔室中的轴，驱动地连接到轴的马达，固定到轴上并从腔室内向外延伸的喷嘴支撑件，以及具有固定到喷嘴支撑件上的内部通道的喷嘴 当马达驱动地转动轴时，喷嘴在腔室中移动。 该室内具有多相流体。 喷嘴移动通过流体，使得流体以与喷嘴移动通过流体的速率相同的速率通过内部通道。 另一个喷嘴可以固定在与喷嘴直径相对的喷嘴支架上。
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公开(公告)号：US20070129305A1
公开(公告)日：2007-06-07
申请号：US11294421
申请日：2005-12-06
CPC分类号： C07K14/00
摘要： The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.
摘要翻译： 本发明涉及细胞穿透肽，其包含由GLX 9 WRAX 9 WRX 1 LX 2 / SEQ ID NO：1组成的氨基酸序列， 3 （SEQ ID No：1），其中X 1是A，L或G，X 2是 W或不是X 3是R或K，X 4是K，L或S，X 5是L或K，X < S> 6是R或W，X 7是K或S，X 8是A，V或Q，X 9， / SUB>是W，F或Y.这些CPP可用作体外或体内将核酸和/或蛋白质和/或肽递送至细胞的载体。
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公开(公告)号：US08242081B2
公开(公告)日：2012-08-14
申请号：US12096378
申请日：2006-12-05
CPC分类号： C07K14/001 , A61K48/00 , C07K7/08 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.
摘要翻译： 本发明涉及包含由GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8（SEQ ID No：1）组成的氨基酸序列的细胞穿透肽，其中X1为A，L或G，X2为W或无，X3为R或K，X4为K， L或S，X 5为L或K，X 6为R或W，X 7为K或S，X 8为A，V或Q，X 9为W，F或Y.这些CPP可用作递送核酸 酸和/或蛋白质和/或肽在体外或体内。
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公开(公告)号：US20140227344A1
公开(公告)日：2014-08-14
申请号：US14009648
申请日：2012-04-04
IPC分类号： C07K7/08 , A61K31/713 , A61K47/48
CPC分类号： C12N15/113 , A61K31/337 , A61K31/409 , A61K31/704 , A61K31/7072 , A61K31/7105 , A61K31/713 , A61K47/48038 , A61K47/48046 , A61K47/48215 , A61K47/48246 , A61K47/48884 , A61K47/542 , A61K47/543 , A61K47/60 , A61K47/64 , A61K47/6929 , C07K7/08 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/3513 , C12N2320/32
摘要： The présent invention relates to cell-penetrating peptides characterized in that it comprises an amino acid séquence selected in the group consisting of X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8, X1LX2LARWX9LX3X9X4LWX9LX5X6X7X8 and X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8, wherein X1 is beta-A or S, X2 is F or W, X3 is L, W, C or I, X4 is S, A, N or T, Xs is L or W, X6 is W or R, X7 is K or R, X8 is A or none, and X9 is R or S. Thèse peptides exhibit high efficiency, low toxicity and a natural tropism for lung tissues, and can be used either in simple complex with the cargo to be vectorised, or in nanoparticles comprising two layers of cell-pentrating peptides around the cargo.
摘要翻译： 本发明涉及细胞穿透肽，其特征在于其包含在由X1LX2RALWX9LX3X9X4LWX9LX5X6X7X8，X1LX2LARWX9XXXXXXXXXXXLLX5X6X7X8和X1LX2ARLWX9LX3X9X4LWX9LX5X6X7X8中选择的氨基酸选择性，其中X1是β-A或S，X2是F或W，X3是L，W C或I，X 4为S，A，N或T，X为L或W，X 6为W或R，X 7为K或R，X 8为A或无，X 9为R或S. 效率，低毒性和肺组织的自然向性，并且可以与要载体的货物的简单复合物或者包含在货物周围的两层细胞五聚肽的纳米颗粒中使用。
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公开(公告)号：US20090292003A1
公开(公告)日：2009-11-26
申请号：US12096378
申请日：2006-12-05
IPC分类号： A61K31/7088 , C07K14/00 , A61P35/00
CPC分类号： C07K14/001 , A61K48/00 , C07K7/08 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.
摘要翻译： 本发明涉及包含由GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8（SEQ ID No：1）组成的氨基酸序列的细胞穿透肽，其中X1为A，L或G，X2为W或无，X3为R或K，X4为K， L或S，X 5为L或K，X 6为R或W，X 7为K或S，X 8为A，V或Q，X 9为W，F或Y.这些CPP可用作递送核酸 酸和/或蛋白质和/或肽在体外或体内。
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公开(公告)号：US07514530B2
公开(公告)日：2009-04-07
申请号：US10831342
申请日：2004-04-26
CPC分类号： A61K47/64
摘要： Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.
摘要翻译： 包含SEQ ID NO：1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2的肽载体和合适的siRNA的复合物，其中R 1表示任何氨基酸残基，更优选K或S，R 2为空或表示以下基团之一：半胱胺，半胱氨酸，硫醇，酰胺， 线性或分枝的任选取代的C1-C6烷基，伯胺或仲胺，奥昔克酸衍生物，脂质，磷脂或胆固醇，并且选择所述siRNA使靶mRNA沉默。
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