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公开(公告)号：US07867992B2
公开(公告)日：2011-01-11
申请号：US11655589
申请日：2007-01-19
申请人： Holger Zimmermann , Rudolf Schohe-Loop , Kerstin Henninger , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Daniela Paulsen , Thomas Roelle , Johannes Koebberling , Marcus Bauser
发明人： Holger Zimmermann , Rudolf Schohe-Loop , Kerstin Henninger , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Daniela Paulsen , Thomas Roelle , Johannes Koebberling , Marcus Bauser
IPC分类号： A01N43/62 , A61K31/55 , C07D413/00
CPC分类号： C07D215/56 , C07D401/04
摘要： The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译： 本发明涉及取代的喹诺酮及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。
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公开(公告)号：US20100216973A1
公开(公告)日：2010-08-26
申请号：US12774652
申请日：2010-05-05
IPC分类号： C07K7/06
CPC分类号： C07K7/06
摘要： The invention relates to methods for the targeted production of lysobactin derivatives by combined chemical and enzymatic modifications. In particular, the invention relates to method for preparing lysobactin fragment 4-11 by chemical reduction and cleavage of the resultant product by chymotrypsin.
摘要翻译： 本发明涉及通过组合的化学和酶修饰靶向生产溶葡萄球菌素衍生物的方法。 特别地，本发明涉及通过化学还原并通过胰凝乳蛋白酶切割所得产物来制备溶菌球蛋白片段4-11的方法。
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公开(公告)号：US07727956B2
公开(公告)日：2010-06-01
申请号：US11788690
申请日：2007-04-19
申请人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
发明人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
IPC分类号： A61K38/00 , A61K38/12 , A61K39/00 , C07K5/00 , C07K7/00 , C07K7/54 , C07K9/00 , C07K16/00 , C07K17/00
摘要： Nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases are described.
摘要翻译： 描述了非吸收肽及其制备方法及其用于生产用于治疗和/或预防疾病，特别是细菌感染性疾病的药物的用途。
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公开(公告)号：US20090181996A1
公开(公告)日：2009-07-16
申请号：US12188940
申请日：2008-08-08
申请人： Chantal Fuerstner , Kai Thede , Holger Zimmermann , David Brueckner , Kerstin Henninger , Dieter Lang , Rudolf Schohe-Loop
发明人： Chantal Fuerstner , Kai Thede , Holger Zimmermann , David Brueckner , Kerstin Henninger , Dieter Lang , Rudolf Schohe-Loop
IPC分类号： A61K31/4709 , C07D401/10 , C07D471/10 , C07D498/10 , C07D401/14 , A61P31/12
CPC分类号： C07D401/04 , C07D401/14 , C07D471/10
摘要： The invention relates to substituted quinolones and to methods for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译： 本发明涉及取代的喹诺酮类及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。
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公开(公告)号：US07786079B2
公开(公告)日：2010-08-31
申请号：US11788590
申请日：2007-04-19
申请人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
发明人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
CPC分类号： C07K7/06
摘要： The invention relates to nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译： 本发明涉及非吸收肽及其制备方法及其用于生产用于治疗和/或预防疾病，特别是细菌感染性疾病的药物的用途。
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公开(公告)号：US07718611B2
公开(公告)日：2010-05-18
申请号：US11800495
申请日：2007-05-04
申请人： Franz Von Nussbaum , Nina Brunner , Chantal Fuerstner , Rainer Endermann , Jacques Ragot , Joachim Telser , Werner Schroeder , Sonja Anlauf , Joachim Schuhmacher , Elke Hartmann
发明人： Franz Von Nussbaum , Nina Brunner , Chantal Fuerstner , Rainer Endermann , Jacques Ragot , Joachim Telser , Werner Schroeder , Sonja Anlauf , Joachim Schuhmacher , Elke Hartmann
CPC分类号： C07K7/56
摘要： The invention relates to cyclic nonapeptide amides and to methods for their preparation and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially bacterial infectious diseases.
摘要翻译： 本发明涉及环状非肽肽酰胺及其制备方法及其用于生产用于治疗和/或预防疾病，特别是细菌感染性疾病的药物。
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公开(公告)号：US07531507B2
公开(公告)日：2009-05-12
申请号：US11267063
申请日：2005-11-04
申请人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Holger Paulsen , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
发明人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Holger Paulsen , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
CPC分类号： C07K7/06
摘要： The invention relates to nonadepsipeptides and processes for their preparation, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译： 本发明涉及非肽缩肽及其制备方法，以及它们用于生产药物用于治疗和/或预防疾病，特别是细菌感染性疾病的用途。
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公开(公告)号：US20080058251A1
公开(公告)日：2008-03-06
申请号：US11788590
申请日：2007-04-19
申请人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
发明人： Franz Von Nussbaum , Nina Brunner , Rainer Endermann , Chantal Fuerstner , Elke Hartmann , Jacques Ragot , Guido Schiffer , Joachim Schuhmacher , Niels Svenstrup , Joachim Telser , Sonja Anlauf , Michael-Alexander Bruening
CPC分类号： C07K7/06
摘要： The invention relates to nonadepsipeptides and methods for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译： 本发明涉及非吸收肽及其制备方法及其用于生产用于治疗和/或预防疾病，特别是细菌感染性疾病的药物。
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公开(公告)号：US20070293478A1
公开(公告)日：2007-12-20
申请号：US11655589
申请日：2007-01-19
申请人： Holger Zimmermann , Rudolph Schohe-loop , Kerstin Henninger , Daniela Paulsen , Thomas Roelle , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Johannes Koebberling , Marcus Bauser
发明人： Holger Zimmermann , Rudolph Schohe-loop , Kerstin Henninger , Daniela Paulsen , Thomas Roelle , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Johannes Koebberling , Marcus Bauser
IPC分类号： A61K31/497 , A61K31/5377 , A61K31/5513 , A61P31/22 , C07D243/08 , C07D401/02 , C07D413/14
CPC分类号： C07D215/56 , C07D401/04
摘要： The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译： 本发明涉及取代的喹诺酮及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。
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公开(公告)号：US07737120B2
公开(公告)日：2010-06-15
申请号：US11800102
申请日：2007-05-04
CPC分类号： C07K7/06
摘要： The invention relates to methods for the targeted production of lysobactin derivatives by combined chemical and enzymatic modifications. In particular, the invention relates to method for preparing lysobactin fragment 4-11 by chemical reduction and cleavage of the resultant product by chymotrypsin.
摘要翻译： 本发明涉及通过组合的化学和酶修饰靶向生产溶葡萄球菌素衍生物的方法。 特别地，本发明涉及通过化学还原并通过胰凝乳蛋白酶切割所得产物来制备溶菌球蛋白片段4-11的方法。
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