公开(公告)号：US08553219B2

公开(公告)日：2013-10-08

申请号：US13012529

申请日：2011-01-24

申请人： Chetan A. Patil ,  Anita Mahadevan-Jansen ,  Antonius Gerardus Johannes Maria Van Leeuwen ,  Jeroen Kalkman

发明人： Chetan A. Patil ,  Anita Mahadevan-Jansen ,  Antonius Gerardus Johannes Maria Van Leeuwen ,  Jeroen Kalkman

IPC分类号： G01J3/44 ,  G01J3/45 ,  G01N21/00 ,  G01B9/02

CPC分类号： G01B9/02044 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/442 ,  A61B5/443 ,  G01B9/0203 ,  G01B9/02091 ,  G01J3/44 ,  G01J3/453 ,  G01N21/4795 ,  G01N21/65 ,  G01N2021/1787

摘要： An apparatus includes first and second light sources for respectively generating broadband and monochromatic lights, a beamsplitter optically coupled to the first light source for splitting the broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, a sample arm optically coupled to the beamsplitter and the second light source for combining the sample and monochromatic lights, delivering the combined light to the target of interest, collecting a backscattering light and a Raman scattering light generated from interaction of the combined light with the target of interest, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path.

摘要翻译： 一种装置包括用于分别产生宽带和单色光的第一和第二光源，光耦合到第一光源的分束器，用于将宽带光分成参考光和采样光;参考臂，光耦合到分束器，用于接收 参考光并将接收到的参考光返回到分光器中，样品臂光耦合到分束器和第二光源，用于组合样品和单色光，将组合的光输送到感兴趣的目标，收集后向散射光和拉曼 由组合光与感兴趣的目标的相互作用产生的散射光，将后向散射光返回到分光器中，以便在分光器中产生返回的后向散射光与返回的参考光之间的干涉信号，并将拉曼散射光引导到 输出光路。

公开(公告)号：US20120188538A1

公开(公告)日：2012-07-26

申请号：US13012529

申请日：2011-01-24

申请人： Chetan A. Patil ,  Anita Mahadevan-Jansen ,  Antonius Gerardus Johannes Maria van Leeuwen ,  Jeroen Kalkman

发明人： Chetan A. Patil ,  Anita Mahadevan-Jansen ,  Antonius Gerardus Johannes Maria van Leeuwen ,  Jeroen Kalkman

IPC分类号： G01J3/44 ,  G01B9/02

CPC分类号： G01B9/02044 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/442 ,  A61B5/443 ,  G01B9/0203 ,  G01B9/02091 ,  G01J3/44 ,  G01J3/453 ,  G01N21/4795 ,  G01N21/65 ,  G01N2021/1787

摘要： In one aspect of the present invention, an apparatus includes a first light source for generating a broadband light, and a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting the received broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, and a sample arm optically coupled to the beamsplitter and the second light source for combining the sample light and the monochromatic light, delivering the combined sample and monochromatic light to the target of interest, collecting a backscattering light and a Raman scattering light that are generated from interaction of the sample light and the monochromatic light with the target of interest, respectively, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path, and a single detector optically coupled to the beamsplitter for collecting the interference signal.

摘要翻译： 在本发明的一个方面中，一种装置包括用于产生宽带光的第一光源和用于产生单色光的第二光源，光学耦合到第一光源的分束器，用于接收宽带光并分离所接收的 将宽带光转换为参考光和采样光，参考臂光耦合到分束器，用于接收参考光并将接收到的参考光返回到分光器中;以及样品臂，光学耦合到分束器和第二光源，用于组合 样品光和单色光，将组合的样品和单色光输送到感兴趣的目标，分别收集从样品光和单色光与感兴趣的目标的相互作用产生的后向散射光和拉曼散射光 ，将后向散射光返回到分束器中以产生 在分束器中返回的后向散射光和返回的参考光之间产生干涉信号，并将拉曼散射光引导到输出光路中，以及单个检测器，其光耦合到分束器以收集干扰信号。

公开(公告)号：US07508524B2

公开(公告)日：2009-03-24

申请号：US11780793

申请日：2007-07-20

申请人： Anita Mahadevan-Jansen ,  Ton Van Leeuwen ,  Chetan A. Patil

发明人： Anita Mahadevan-Jansen ,  Ton Van Leeuwen ,  Chetan A. Patil

IPC分类号： G01B9/02

CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/444 ,  A61B5/445 ,  G01B9/0203 ,  G01B9/02089 ,  G01B9/02091 ,  G01B2290/35 ,  G01N21/65

摘要： An apparatus for evaluating a target of interest of a living subject. In one embodiment, the apparatus has a first light source for generating a broadband light, a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting it into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning it into the beamsplitter, and a probe having a working end placed proximal to a target of interest of a living subject, optically coupled to the beamsplitter and the second light source for receiving the sample light and the monochromatic light, delivering them from the working end to the target of interest, collecting from the working end a backscattering light and a Raman scattering light that are obtained from interaction of the sample light and the monochromatic light with the target of interest, respectively, and returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter.

摘要翻译： 一种用于评估活体感兴趣的目标的装置。 在一个实施例中，该装置具有用于产生宽带光的第一光源，用于产生单色光的第二光源，光学耦合到第一光源的分束器，用于接收宽带光并将其分割为参考光和 样品光，参考臂，其光学耦合到分束器，用于接收参考光并将其返回到分束器中;以及探针，其具有放置在活体的感兴趣目标附近的工作端，光学耦合到分束器，第二 用于接收样品光和单色光的光源，将其从工作端传送到感兴趣的目标，从工作端收集从样品光和单色光的相互作用获得的后向散射光和拉曼散射光 分别与感兴趣的目标，并将后向散射光返回到分束器中以便发射 在分束器中消除返回的后向散射光与返回的参考光之间的干扰信号。

公开(公告)号：US20090021724A1

公开(公告)日：2009-01-22

申请号：US11780793

申请日：2007-07-20

申请人： Anita MAHADEVAN-JANSEN ,  Ton Van Leeuwen ,  Chetan A. Patil

发明人： Anita MAHADEVAN-JANSEN ,  Ton Van Leeuwen ,  Chetan A. Patil

IPC分类号： G01N21/00

CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/444 ,  A61B5/445 ,  G01B9/0203 ,  G01B9/02089 ,  G01B9/02091 ,  G01B2290/35 ,  G01N21/65

摘要： An apparatus for evaluating a target of interest of a living subject. In one embodiment, the apparatus has a first light source for generating a broadband light, a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting it into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning it into the beamsplitter, and a probe having a working end placed proximal to a target of interest of a living subject, optically coupled to the beamsplitter and the second light source for receiving the sample light and the monochromatic light, delivering them from the working end to the target of interest, collecting from the working end a backscattering light and a Raman scattering light that are obtained from interaction of the sample light and the monochromatic light with the target of interest, respectively, and returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter.

摘要翻译： 一种用于评估活体感兴趣的目标的装置。 在一个实施例中，该装置具有用于产生宽带光的第一光源，用于产生单色光的第二光源，光学耦合到第一光源的分束器，用于接收宽带光并将其分割为参考光和 样品光，参考臂，其光学耦合到分束器，用于接收参考光并将其返回到分束器中;以及探针，其具有放置在活体的感兴趣目标附近的工作端，光学耦合到分束器，第二 用于接收样品光和单色光的光源，将其从工作端传送到感兴趣的目标，从工作端收集从样品光和单色光的相互作用获得的后向散射光和拉曼散射光 分别与感兴趣的目标，并将后向散射光返回到分束器中以便发射 消除返回的后向散射光和分束器中返回的参考光之间的干扰信号。