摘要:
The present application relates to indole and indoline derivatives of formula (I) wherein a, R1, R2, R3, h, i, j, m, n, L, Q, and X are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions.
摘要:
The invention relates to isoxazole derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions.
摘要:
One exemplary signal amplification circuit used for processing an input signal includes an input stage, a plurality of output stages, and a selecting stage. The input stage has an input node for receiving the input signal and an output node for outputting an intermediate signal. The output stages are coupled to a plurality of output ports of the signal amplification circuit, respectively. Each of the output stages generates a corresponding processed signal to a corresponding output port according to a gain and a signal derived from the intermediate signal of the input stage when enabled. The selecting stage is arranged for selectively coupling the output node of the input stage to at least one of the output stages.
摘要:
The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.
摘要:
The invention relates to compounds that are spirocyclic azaadamantane derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
摘要:
The invention provides a method for determining a risk, for a subject, of suffering from atopic dermatitis, including: obtaining a biosample of the subject; detecting the presence of the single-nucleotide polymorphism rs12313273 (C/T) at position 30881 of the ORAI1 gene (SEQ ID No.: 1) in the biosample; and determining the risk, for the subject, of suffering from atopic dermatitis, wherein the presence of a C allele or genotype CC of the single-nucleotide polymorphism rs12313273 (C/T) indicates that the subject is at increased risk for suffering from atopic dermatitis.
摘要翻译:本发明提供了一种用于确定受试者患有特应性皮炎的风险的方法,包括:获得受试者的生物样品; 检测生物样品中ORAI1基因(SEQ ID No .: 1)的30881位单核苷酸多态性rs12313273(C / T)的存在; 并确定受试者患有特应性皮炎的风险,其中单核苷酸多态性rs12313273(C / T)的C等位基因或基因型CC的存在表明受试者处于患有特应性皮炎的风险增加 。
摘要:
A clock data recovery circuit. The clock data recovery circuit comprises a transmission line, a phase locked loop, a voltage controlled oscillator, a phase selector, and a D flip-flop. The transmission line receives an input signal. The phase locked loop receives the input signal via the transmission line and a reference clock and generates a first clock signal. The voltage controlled oscillator receives the input signal via the transmission line and a control voltage from an internal node of the phase locked loop, and generates a clock signal. The phase selector receives the input signal via the transmission line and the clock signal from the voltage controlled oscillator, and generates a clock output signal. The D flip-flop receives the input signal via the transmission line and the clock output signal, and generates a data output signal.
摘要:
The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要:
A limiting amplifier with an input stage with dc offset cancellation, identical gain stages, an output buffer and a feedback filter. The input stage receives a differential input signal and outputs a first intermediate differential signal. The gain stages are cascaded to amplify the first intermediate differential signal and generate a second intermediate differential signal, amplified by the output buffer to produce an output signal. The feedback filter provides a dc offset voltage of the output signal to the input stage for the dc offset cancellation. The input stage comprises a resistor network coupled between a pair of input nodes and a power line and comprising a common resistor, a pair of load resistors and a shunt resistor. The load resistors share a common terminal connected to the common resistor that is connected to the power line. The shunt resistor has two terminals respectively connected to the load resistors.
摘要:
The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.