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公开(公告)号：US09341635B2
公开(公告)日：2016-05-17
申请号：US13497875
申请日：2010-09-08
申请人： Christian Baumann , Stefan Kienle , Karsten Kuhn , Harald Legner
发明人： Christian Baumann , Stefan Kienle , Karsten Kuhn , Harald Legner
IPC分类号： C40B30/10 , C40B40/04 , C07D401/12 , G01N33/74 , C07B59/00 , C07D211/14 , G01N33/58
CPC分类号： G01N33/743 , C07B59/002 , C07D211/14 , C07D401/12 , G01N33/58 , G01N2458/15 , G01N2560/00 , Y10T436/196666 , Y10T436/200833 , Y10T436/24
摘要： A reactive mass label for labelling a biological molecule for detection by mass spectrometry, which label comprises a reactive functionality for labelling thiol groups or carbonyl groups. Also provided is a reactive mass label for labelling a biological molecule for detection by mass spectrometry, wherein the mass label comprises the following structure: X-L-M-S—Re wherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, S is a mass series modifying group comprising the following group: wherein J is C═O, K is NH, and n is 2 or J and K are both CH2 and n is 1, and wherein m is at least 1; and Re is a reactive functionality for attaching the mass label to a biological molecule.
摘要翻译： 用于通过质谱法标记用于检测的生物分子的反应性质量标签，该标记包括用于标记巯基或羰基的反应性官能团。 还提供了用于通过质谱法标记用于检测的生物分子的反应性质量标签，其中所述质量标签包含以下结构：XLMS-Re，其中X是质量标记物部分，L是可切割接头，M是质量归一化部分 S是包含以下基团的质量系列改性基团：其中J为C = O，K为NH，n为2或J和K均为CH 2，n为1，m为至少1; 并且Re是用于将质量标签附着到生物分子的反应性官能团。
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公开(公告)号：US09016203B2
公开(公告)日：2015-04-28
申请号：US12674653
申请日：2008-07-25
CPC分类号： F42C19/0826
摘要： The invention relates to producing a propellant charge igniter tube (2) for a propellant charge igniter (1) by means of hydroforming (high-pressure forming). According to the present invention, a sleeve base (6) is then joined to the propellant charge igniter tube (2) by means of friction welding, for example, and vulcanized without reworking. In this context, the rubber lips of the sleeve base (6) and the propellant charge igniter tube (2) are molded on, or vulcanized, on in one operation. The vacuum-packed benites (8) and the lower part (9) of the propellant charge igniter (1) can then be mounted in the sleeve base (6).
摘要翻译： 本发明涉及通过液压成型（高压成型）生产用于推进剂充电点火器（1）的推进剂充电点火器管（2）。 根据本发明，然后例如通过摩擦焊接将套筒基座（6）与推进剂充电点火器管（2）接合，并在不进行再加工的情况下进行硫化。 在这种情况下，套筒基座（6）和推进剂充电点火器管（2）的橡胶唇在一个操作中被模制或硫化。 然后将推进剂充气点火器（1）的真空包装的宝石（8）和下部（9）安装在套管基座（6）中。
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公开(公告)号：US08561544B2
公开(公告)日：2013-10-22
申请号：US12733186
申请日：2008-07-25
IPC分类号： F42B14/06
CPC分类号： F42B14/064 , F42B14/065
摘要： The invention relates to a projectile (1) having a sub-caliber projectile core (2) and a guide cage or sabot (3) that comprises a driving element (4), which acts on the projectile core (2) at the rear thereof and is in the form of a plate composed of metal. In order to produce such a projectile (1) at low cost, the projectile core (2) and the driving element (4), which is in the form of a plate, are inserted as inserts into an injection-molding tool, and are extrusion-coated so that the injection-mold shape is chosen so that the contour of the guide cage or sabot (3) of the projectile (1) is produced after the injection-molding process.
摘要翻译： 本发明涉及一种具有副口径射弹核心（2）的射弹（1）和引导笼或火炮（3），其包括驱动元件（4），驱动元件（4）在其后部作用在射弹核心（2）上 并且是由金属组成的板的形式。 为了以低成本制造这种射弹（1），将弹片（2）和板状驱动元件（4）作为插入件插入注射成型工具中，并且 挤压涂布，使得注塑模具形状被选择为使得在注射成型工艺之后产生抛射体（1）的引导笼或铸件（3）的轮廓。
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公开(公告)号：US08424457B2
公开(公告)日：2013-04-23
申请号：US12489591
申请日：2009-06-23
IPC分类号： F42B14/06
CPC分类号： F42B5/18 , F42B14/064
摘要： A sabot projectile with a subcaliber projectile body and a sabot, which includes a propulsion element that acts on the rear end of the projectile body and a segmented, essentially cylindrical metal guide cage, which is located at the front end of the propulsion element. The guide cage has a central opening that extends in the axial direction, through which the projectile body is passed. So that the sabot projectile is relatively inexpensive to manufacture, has a low weight, and ensures good detachment of the sabot from the projectile body after discharge, the guide cage is a hollow cylinder, on whose inside wall preferably several radial transverse ribs are arranged, which are spaced some distance apart and extend both in the direction of the longitudinal axis of the sabot and in the direction of the projectile body.
摘要翻译： 具有亚型射弹体和膛体的破坏射弹，其包括作用在射弹体后端的推进元件和位于推进元件前端的分段的基本上圆柱形的金属引导笼。 导向架具有沿轴向延伸的中心开口，射弹体通过该中心开口。 因此，制造抛物体相对便宜，重量轻，并且能够在排出后确保弹丸与射弹体的良好分离，导向架是中空圆筒，其内壁优选为多个径向横向肋， 它们间隔开一定距离，并且在炮弹的纵向轴线的方向上并沿射弹体的方向延伸。
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公开(公告)号：US08408139B2
公开(公告)日：2013-04-02
申请号：US12786124
申请日：2010-05-24
申请人： Christian Baumann , Thomas Heitmann
发明人： Christian Baumann , Thomas Heitmann
IPC分类号： F42B12/22
CPC分类号： F42B12/22 , F42B12/207 , F42B12/625
摘要： A projectile (1) is optionally used as a fragmentation projectile or as a projectile that utilizes a pressure wave effect created when the explosive charge (3) explodes. The projectile (1) contains an ejection charge (12), and an explosive charge (3) arranged in a jacket (4) that can be moved axially with respect to a fragmentation casing (5). The ejection charge (12) allows the explosive charge (3) and surrounding jacket (4) to be pushed at least so far out of the projectile casing (2) that, in the event of explosion, the explosive charge does not act on the fragmentation casing (5). In order to ensure that the jacket (4) of the explosive charge (3) does not develop any fragmentation effect, or develops only a small fragmentation effect, when the explosive charge (3) is ignited, a molded part composed of plastic or a light alloy is used as the jacket (4).
摘要翻译： 抛射体（1）可选地用作碎裂射弹或使用当爆炸炸药（3）爆炸时产生的压力波效应的射弹。 射弹（1）包含喷射装置（12）和布置在护套（4）中的爆炸装药（3），其可以相对于碎裂壳体（5）轴向移动。 喷射装置（12）允许爆炸装药（3）和周围护套（4）至少被推到射弹套管（2）外，即在爆炸的情况下，爆炸装药不会对 碎片套（5）。 为了确保炸药（3）的护套（4）不会产生任何碎裂效应，或仅产生小碎裂效应，当炸药（3）被点燃时，由塑料或 轻合金用作护套（4）。
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公开(公告)号：US20120283137A1
公开(公告)日：2012-11-08
申请号：US13497875
申请日：2010-09-08
申请人： Christian Baumann , Stefan Kienle , Karsten Kuhn , Harald Legner
发明人： Christian Baumann , Stefan Kienle , Karsten Kuhn , Harald Legner
IPC分类号： C07D401/12 , C40B30/10 , C40B40/04 , C07D211/14 , G01N27/72
CPC分类号： G01N33/743 , C07B59/002 , C07D211/14 , C07D401/12 , G01N33/58 , G01N2458/15 , G01N2560/00 , Y10T436/196666 , Y10T436/200833 , Y10T436/24
摘要： A reactive mass label for labelling a biological molecule for detection by mass spectrometry, which label comprises a reactive functionality for labelling thiol groups or carbonyl groups. Also provided is a reactive mass label for labelling a biological molecule for detection by mass spectrometry, wherein the mass label comprises the following structure: X-L-M-S-Re wherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, S is a mass series modifying group comprising the following group: wherein J is C═O, K is NH, and n is 2 or J and K are both CH2 and n is 1, and wherein m is at least 1; and Re is a reactive functionality for attaching the mass label to a biological molecule.
摘要翻译： 用于通过质谱法标记用于检测的生物分子的反应性质量标签，该标记包括用于标记巯基或羰基的反应性官能团。 还提供了用于通过质谱法标记用于检测的生物分子的反应性质量标签，其中所述质量标签包含以下结构：XLMS-Re，其中X是质量标记物部分，L是可切割接头，M是质量归一化部分 S是包含以下基团的质量系列改性基团：其中J为C = O，K为NH，n为2或J和K均为CH 2，n为1，m为至少1; 并且Re是用于将质量标签附着到生物分子的反应性官能团。
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公开(公告)号：US20110259225A1
公开(公告)日：2011-10-27
申请号：US12674653
申请日：2008-07-25
CPC分类号： F42C19/0826
摘要： The invention relates to producing a propellant charge igniter tube (2) for a propellant charge igniter (1) by means of hydroforming (high-pressure forming). According to the present invention, a sleeve base (6) is then joined to the propellant charge igniter tube (2) by means of friction welding, for example, and vulcanized without reworking. In this context, the rubber lips of the sleeve base (6) and the propellant charge igniter tube (2) are molded on, or vulcanized, on in one operation. The vacuum-packed benites (8) and the lower part (9) of the propellant charge igniter (1) can then be mounted in the sleeve base (6).
摘要翻译： 本发明涉及通过液压成型（高压成型）生产用于推进剂充电点火器（1）的推进剂充电点火器管（2）。 根据本发明，然后例如通过摩擦焊接将套筒基座（6）与推进剂充电点火器管（2）接合，并在不进行再加工的情况下进行硫化。 在这种情况下，套筒基座（6）和推进剂充电点火器管（2）的橡胶唇在一个操作中被模制或硫化。 然后将推进剂充气点火器（1）的真空包装的宝石（8）和下部（9）安装在套管基座（6）中。
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公开(公告)号：US20110111513A1
公开(公告)日：2011-05-12
申请号：US12994400
申请日：2009-05-18
CPC分类号： G01N33/6848 , Y10T436/143333
摘要： The disclosure provides a method for assaying for a target analyte, comprising providing a plurality of samples which may comprise the target analyte, wherein each sample is differentially labelled with a mass label or a combination of mass labels, wherein the mass labels are from a set of mass labels, wherein each mass label is an isobaric mass label comprising a mass spectrometrically distinct mass marker group, such that the samples can be distinguished by mass spectrometry and determining from the mass spectrum the quantity of the target analyte in each sample.
摘要翻译： 本公开提供了一种用于分析目标分析物的方法，包括提供可包含目标分析物的多个样品，其中每个样品用质量标签或质量标签的组合差异标记，其中质量标签来自一组 的质量标签，其中每个质量标签是包含质谱分辨率不同的质量标记物组的等压质量标签，使得可以通过质谱法区分样品，并从质谱确定每个样品中的目标分析物的量。
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公开(公告)号：US20100132579A1
公开(公告)日：2010-06-03
申请号：US12495912
申请日：2009-07-01
CPC分类号： F42C19/06 , Y10T29/49002
摘要： A projectile in which the metallic base body itself is used as a ground wire and only the signal line is passed through the inside of the base body so that it is insulated by a suitable bore of the base body. The signal line is insulated from the ground wire by a coating of an electrically insulating material applied to the base body, before the signal line is introduced into the bore. The two ends of the signal line are provided with connecting contacts, which preferably can be screwed at least partially into the base body and are mounted in such a way that they are insulated from the base body. To allow contacting of the ground wire, which is formed by the base body itself, the front end and the rear end of the base body are provided with coating-free blind bores.
摘要翻译： 使用金属基体本身作为接地线的射弹，只有信号线通过基体的内部，使其通过基体的合适的孔绝缘。 在信号线被引入孔内之前，信号线通过施加到基体的电绝缘材料的涂层与接地线绝缘。 信号线的两端设置有连接触点，其优选地可以至少部分地拧入基体中并且以使得它们与基体绝缘的方式安装。 为了允许由基体本身形成的接地线与基体的前端和后端的接触设置有无涂层盲孔。
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公开(公告)号：US20060281768A1
公开(公告)日：2006-12-14
申请号：US11422359
申请日：2006-06-06
申请人： Michael Gaul , Kevin Kreutter , Christian Baumann
发明人： Michael Gaul , Kevin Kreutter , Christian Baumann
IPC分类号： A61K31/519 , A61K31/4743 , C07D498/02
CPC分类号： C07D495/04
摘要： The invention is directed to thienopyrimidines and thienopyridines compounds of Formula I and Formula II: where R1, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3, the use of such compounds to reduce or inhibit kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译： 本发明涉及式I和式II的噻吩并嘧啶和噻吩并吡啶化合物：其中R 1，R 3，B，Z，Q，p，q和X分别为 本文定义的蛋白酪氨酸激酶调节剂，特别是FLT3抑制剂的这种化合物在细胞或受试者中使用这些化合物来降低或抑制FLT3的激酶活性，以及使用这些化合物预防或治疗 受试者与FLT3相关的细胞增殖性疾病和/或障碍。 本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。
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