公开(公告)号：US20140056500A1

公开(公告)日：2014-02-27

申请号：US13970753

申请日：2013-08-20

申请人： Girish Bal ,  Frank Kehren ,  Vladimir Y. Panin ,  Christian J. Michel ,  Johan Nuyts

发明人： Girish Bal ,  Frank Kehren ,  Vladimir Y. Panin ,  Christian J. Michel ,  Johan Nuyts

IPC分类号： G06T11/00

CPC分类号： G06T11/005

摘要： The DCC (Data Consistency Condition) algorithm is used in combination with MLAA (Maximum Likelihood reconstruction of Attenuation and Activity) to generate extended attenuation correction maps for nuclear medicine imaging studies. MLAA and DCC are complementary algorithms that can be used to determine the accuracy of the mu-map based on PET data. MLAA helps to estimate the mu-values based on the biodistribution of the tracer while DCC checks if the consistency conditions are met for a given mu-map. These methods are combined to get a better estimation of the mu-values. In gated MR/PET cardiac studies, the PET data is framed into multiple gates and a series of MR based mu-maps corresponding to each gate is generated. The PET data from all gates is combined. Once the extended mu-map is generated the central region is replaced with the MR based mu-map corresponding to that particular gate. On the other hand, in dynamic PET studies the uptake in the patient's arms reaches a steady state only after the tracer distributes throughout the body. Hence, for dynamic scans, the projection data of all frames is summed and used to generate the MLAA based extended mu-map for all frames.

摘要翻译： DCC（数据一致条件）算法与MLAA（衰减和活动的最大似然重构）结合使用，以产生用于核医学成像研究的扩展衰减校正图。 MLAA和DCC是可以用于基于PET数据确定mu-map精度的互补算法。 MLAA有助于根据示踪剂的生物分布估计μ值，而DCC检查是否满足给定mu-map的一致性条件。 将这些方法组合起来，以便更好地估计μ值。 在门控MR / PET心脏研究中，PET数据被框架成多个门，并且生成与每个门对应的一系列基于MR的mu图。 来自所有门的PET数据被组合。 一旦生成了扩展的mu-map，就将中心区域替换为与该特定门对应的基于MR的mu-map。 另一方面，在动态PET研究中，仅在跟踪器分布在整个身体之后，患者的手臂中的摄取才达到稳定状态。 因此，对于动态扫描，将所有帧的投影数据求和并用于为所有帧生成基于MLAA的扩展mu-map。

公开(公告)号：US20130032721A1

公开(公告)日：2013-02-07

申请号：US13198804

申请日：2011-08-05

申请人： Christian J. Michel ,  Maurizio Conti ,  Ronald Grazioso ,  Piotr Szupryczynski ,  A. Andrew Carey ,  Larry Byars

发明人： Christian J. Michel ,  Maurizio Conti ,  Ronald Grazioso ,  Piotr Szupryczynski ,  A. Andrew Carey ,  Larry Byars

IPC分类号： G01T1/202 ,  G01T1/20

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01T1/1615 ,  G01T1/202

摘要： Apparatuses, computer-readable mediums, and methods are provided. In one embodiment, a positron emission tomography (“PET”) detector array is provided which includes a plurality of crystal elements arranged in a two-dimensional checkerboard configuration. In addition, there are empty spaces in the checkerboard configuration. In various embodiments, the empty spaces are filled with passive shielding, transmission source assemblies, biopsy instruments, surgical instruments, and/or electromagnetic sensors. In various embodiments, the crystal elements and the transmission source assemblies simultaneously perform emission/transmission acquisitions.

摘要翻译： 提供了设备，计算机可读介质和方法。 在一个实施例中，提供了一种正电子发射断层摄影（PET）检测器阵列，其包括以二维棋盘配置布置的多个晶体元件。 另外，棋盘配置中有空格。 在各种实施例中，空的空间填充有无源屏蔽，传输源组件，活检仪器，外科器械和/或电磁传感器。 在各种实施例中，晶体元件和传输源组件同时执行发射/传输采集。

公开(公告)号：US08193505B2

公开(公告)日：2012-06-05

申请号：US12569051

申请日：2009-09-29

申请人： Charles C. Watson ,  Larry Byars ,  Christian J. Michel ,  Harold Rothfuss

发明人： Charles C. Watson ,  Larry Byars ,  Christian J. Michel ,  Harold Rothfuss

IPC分类号： G01T1/164

CPC分类号： G01T1/1647

摘要： In positron emission tomography (PET), a detector's response to scattered radiation may be different from its response to unscattered (true coincidence) photons. This difference should be accounted for during normalization and scatter correction. The disclosure shows that only a knowledge of the ratio of the scatter to trues efficiencies is necessary, however. A system and method are disclosed for measuring the scatter/trues detection efficiency ratio, as well as for applying this compensation during the scatter correction of PET emission data. PET detector efficiencies are measured in two steps, the first using a plane radiation source, and the second using a plane radiation source in combination with a scattering medium. A ratio of the scatter and trues detection efficiency is obtained from this data for each detector/crystal, and is applied as a correction factor to PET data obtained during medical imaging processes.

摘要翻译： 在正电子发射断层扫描（PET）中，检测器对散射辐射的响应可能与其对未散射（真正重合）光子的响应不同。 在归一化和散射校正期间应该考虑这个差异。 该披露表明，然而，仅需要了解分散比与效率的比率。 公开了用于测量散射/三次检测效率比的系统和方法，以及在PET发射数据的散射校正期间应用该补偿。 PET检测器效率以两个步骤测量，第一个使用平面辐射源，第二个使用平面辐射源与散射介质组合。 从每个检测器/晶体的数据获得散射和三次检测效率的比率，并将其作为校正因子应用于在医学成像过程中获得的PET数据。

公开(公告)号：US08155415B2

公开(公告)日：2012-04-10

申请号：US11962556

申请日：2007-12-21

申请人： David D. Faul ,  Christian J. Michel

发明人： David D. Faul ,  Christian J. Michel

IPC分类号： G06K9/00

CPC分类号： A61B6/032 ,  A61B6/037 ,  A61B6/5235 ,  A61B6/5241 ,  G06T11/008

摘要： An apparatus and method for expanding the FOV of a truncated computed tomography (CT) scan. An iterative calculation is performed on the original CT image to produce an estimate of the image. The calculated estimate of the reconstructed image includes the original image center and a estimate of the truncated portion outside the image center. The calculation uses an image mask with the image center as one boundary.

摘要翻译： 一种用于扩展截断计算机断层摄影（CT）扫描的FOV的装置和方法。 对原始CT图像进行迭代计算以产生图像的估计。 所计算的重建图像的估计包括原始图像中心和图像中心外的截断部分的估计。 该计算使用图像中心作为一个边界的图像蒙版。

公开(公告)号：US07848559B2

公开(公告)日：2010-12-07

申请号：US11804265

申请日：2007-05-17

申请人： Michel Defrise ,  Vladimir Panin ,  Christian J. Michel ,  Michael E. Casey

发明人： Michel Defrise ,  Vladimir Panin ,  Christian J. Michel ,  Michael E. Casey

IPC分类号： G06K9/00

CPC分类号： G01T1/2985 ,  A61B6/037

摘要： Axial rebinning methods are provided for 3D time-of-flight (TOF) positron emission tomography (PET), based on 2D data rebinning. Rebinning is performed separately for each axial plane parallel to the axis of the PET scanner. An analytical approach is provided that is based on a consistency condition for TOF-PET data with a gaussian profile. A fully discrete approach is also provided, wherein each 2D TOF-PET data is calculated as a linear combination of 3D TOF-PET data having the same sinogram coordinates s and φ.

摘要翻译： 基于2D数据重组，为3D飞行时间（TOF）正电子发射断层扫描（PET）提供轴向重组方法。 对于平行于PET扫描仪的轴的每个轴向平面分别进行重组。 提供了基于具有高斯分布的TOF-PET数据的一致性条件的分析方法。 还提供了完全离散的方法，其中每个2D TOF-PET数据被计算为具有相同正弦图坐标s和＆phgr的3D TOF-PET数据的线性组合。

公开(公告)号：US20100078568A1

公开(公告)日：2010-04-01

申请号：US12569051

申请日：2009-09-29

申请人： Larry Byars ,  Christian J. Michel ,  Harold Rothfuss ,  Charles C. Watson

发明人： Larry Byars ,  Christian J. Michel ,  Harold Rothfuss ,  Charles C. Watson

IPC分类号： G01T1/164 ,  G01T1/20

CPC分类号： G01T1/1647

摘要： In positron emission tomography (PET), a detector's response to scattered radiation may be different from its response to unscattered (true coincidence) photons. This difference should be accounted for during normalization and scatter correction. The disclosure shows that only a knowledge of the ratio of the scatter to trues efficiencies is necessary, however. A system and method are disclosed for measuring the scatter/trues detection efficiency ratio, as well as for applying this compensation during the scatter correction of PET emission data. PET detector efficiencies are measured in two steps, the first using a plane radiation source, and the second using a plane radiation source in combination with a scattering medium. A ratio of the scatter and trues detection efficiency is obtained from this data for each detector/crystal, and is applied as a correction factor to PET data obtained during medical imaging processes.

摘要翻译： 在正电子发射断层扫描（PET）中，检测器对散射辐射的响应可能与其对未散射（真正重合）光子的响应不同。 在归一化和散射校正期间应该考虑这个差异。 该披露表明，然而，仅需要了解分散比与效率的比率。 公开了用于测量散射/三次检测效率比的系统和方法，以及在PET发射数据的散射校正期间应用该补偿。 PET检测器效率以两个步骤测量，第一个使用平面辐射源，第二个使用平面辐射源与散射介质组合。 从每个检测器/晶体的数据获得散射和三次检测效率的比率，并将其作为校正因子应用于在医学成像过程中获得的PET数据。

公开(公告)号：US20080219534A1

公开(公告)日：2008-09-11

申请号：US11962556

申请日：2007-12-21

申请人： David D. FAUL ,  Christian J. MICHEL

发明人： David D. FAUL ,  Christian J. MICHEL

IPC分类号： A61B6/00

CPC分类号： A61B6/032 ,  A61B6/037 ,  A61B6/5235 ,  A61B6/5241 ,  G06T11/008

摘要： An apparatus and method for expanding the FOV of a truncated computed tomography (CT) scan. An iterative calculation is performed on the original CT image to produce an estimate of the image. The calculated estimate of the reconstructed image includes the original image center and a estimate of the truncated portion outside the image center. The calculation uses an image mask with the image center as one boundary.

摘要翻译： 一种用于扩展截断计算机断层摄影（CT）扫描的FOV的装置和方法。 对原始CT图像进行迭代计算以产生图像的估计。 所计算的重建图像的估计包括原始图像中心和图像中心外的截断部分的估计。 该计算使用图像中心作为一个边界的图像蒙版。

公开(公告)号：US07324624B2

公开(公告)日：2008-01-29

申请号：US11251232

申请日：2005-10-14

申请人： Merence Sibomana ,  Mark W. Lenox ,  Larry Byars ,  Christian J. Michel ,  Danny Newport

发明人： Merence Sibomana ,  Mark W. Lenox ,  Larry Byars ,  Christian J. Michel ,  Danny Newport

IPC分类号： G01T1/29

CPC分类号： G01T1/1615

摘要： Emission contamination data are collected in a shifted mock scan simultaneous with the collection of transmission data during a transmission scan of a patient with a collimated gamma point source, the transmission data are corrected with the emission contamination data, and the corrected transmission data are used for attenuation correction of emission data for reconstruction of an emission image of the patient. In a preferred implementation, when the point source is at a particular axial location and illuminates an axial beamwidth of “Fz” over the gamma detector, emission contamination data are collected from the gamma detector over an axial separated region “Fz′” having about the same axial extent but axially displaced by about half of the axial field of view (FOV).

摘要翻译： 在具有准直伽马点源的患者的发射扫描期间，与移动模拟扫描同时收集发射污染数据，传输数据用排放污染数据进行校正，校正的传输数据用于 用于重建患者的发射图像的发射数据的衰减校正。 在优选实施方案中，当点源处于特定的轴向位置并且照亮伽马检测器上的“Fz”的轴向波束宽度时，从伽马检测器沿着具有大约的轴的分离区域“Fz”收集发射污染数据 相同的轴向范围，但轴向位移约轴向视场（FOV）的一半。

公开(公告)号：US08577114B2

公开(公告)日：2013-11-05

申请号：US13400314

申请日：2012-02-20

申请人： David Faul ,  Christian J. Michel

发明人： David Faul ,  Christian J. Michel

IPC分类号： G06K9/00

CPC分类号： A61B6/032 ,  A61B6/037 ,  A61B6/5235 ,  A61B6/5241 ,  G06T11/008

摘要： An apparatus and method for expanding the FOV of a truncated computed tomography (CT) scan. An iterative calculation is performed on the original CT image to produce an estimate of the image. The calculated estimate of the reconstructed image includes the original image center and a estimate of the truncated portion outside the image center. The calculation uses an image mask with the image center as one boundary.

公开(公告)号：US08457381B2

公开(公告)日：2013-06-04

申请号：US13223527

申请日：2011-09-01

申请人： Inki Hong ,  Michael E Casey ,  Christian J Michel

发明人： Inki Hong ,  Michael E Casey ,  Christian J Michel

IPC分类号： G06K9/00

CPC分类号： G06T11/006 ,  G06T2211/412

摘要： Using complementary reconstruction, images from short time frames may be generated for positron emission tomography. Detected events are gathered over a long period, such as three minutes. The detected events from a short period, such as one or two seconds, are removed. Reconstruction is performed on the detected events from the long period and another reconstruction is performed on the detected events from the long period without the detected events from the short period. The second reconstruction is subtracted from the first, providing data representing the short period. The data may result in better image quality than merely reconstructing an individual frame for the short period.

摘要翻译： 使用互补重建，可以为正电子发射断层扫描生成来自短时间帧的图像。 检测到的事件是长时间收集的，例如三分钟。 从短时间（例如一秒或两秒）中检测到的事件将被删除。 对长时间的检测到的事件进行重建，并且对于长时间的检测到的事件进行另一重建，而没有从短周期检测到的事件。 从第一次减去第二个重建，提供表示短周期的数据。 数据可能会导致更好的图像质量，而不仅仅是在短时间内重建单个帧。