公开(公告)号：US20180185509A1

公开(公告)日：2018-07-05

申请号：US15728170

申请日：2017-10-09

Applicant: Werner Simon ,  Christian Lutz ,  Christoph Müller ,  Jan Anderl

Inventor： Werner Simon ,  Christian Lutz ,  Christoph Müller ,  Jan Anderl

IPC: A61K47/68 ,  A61K38/12 ,  A61K47/64 ,  A61K47/61 ,  A61K47/66

CPC classification number: A61K47/6813 ,  A61K38/12 ,  A61K47/61 ,  A61K47/64 ,  A61K47/66 ,  A61K47/6831 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6891

Abstract: The present disclosure relates to tumour therapy. In one aspect, the present disclosure relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

公开(公告)号：US08603091B2

公开(公告)日：2013-12-10

申请号：US13040722

申请日：2011-03-04

Applicant: Christian Lutz ,  Jakob Kemper

Inventor： Christian Lutz ,  Jakob Kemper

IPC: A61B17/80 ,  A61B17/88

CPC classification number: A61B17/8085 ,  A61B17/8066 ,  A61B17/809

Abstract: The invention relates to a pelvic or scapular bone plate implant having a planar or curved outer frame portion. The frame has a surface which can be aligned with a surface of a bone to which the bone plate is to be implanted. The plate has a flap portion, the outer frame portion at least partially surrounds the flap portion such that the bone contacting surface the flap portion is located within the outer boundary of the frame portion. The flap portion is connected with the outer frame portion via a material interconnection which allows the flap to be bent with respect to the frame. A method for implanting such a bone plate implant is also taught.

Abstract translation: 本发明涉及具有平面或弯曲的外框部分的骨盆或肩胛骨骨板植入物。 框架具有可以与待植入骨板的骨的表面对准的表面。 板具有翼片部分，外框架部分至少部分地围绕翼片部分，使得翼片部分的骨接触表面位于框架部分的外边界内。 翼片部分经由允许翼片相对于框架弯曲的材料互连件与外框架部分连接。 还教导了一种用于植入这种骨板植入物的方法。

公开(公告)号：US08523923B2

公开(公告)日：2013-09-03

申请号：US11641600

申请日：2006-12-19

Applicant: Roland Thomke ,  Christian Lutz ,  Vinzenz Burgherr ,  Damian Fankhauser

Inventor： Roland Thomke ,  Christian Lutz ,  Vinzenz Burgherr ,  Damian Fankhauser

IPC: A61B17/60

CPC classification number: A61B17/6466 ,  A61B17/60 ,  A61B17/645 ,  F16B7/0493 ,  Y10T24/3439 ,  Y10T24/44034 ,  Y10T403/7105

Abstract: A two-piece clamping element comprises two separate, i.e., non-integral, opposing first and second clamping jaws forming a laterally open cavity to receive a pin or rod-shaped element. Each clamping jaw has a bore aligned with one another to receive a screw, wherein a pivot bearing is arranged opposite said cavity allowing the two opposing clamping jaws to come in contact to one another. The pivot bearing comprises at least one set of complementary part-cylindrical bearing surface portions. An anti-rotation pin extends between the two jaw members.

Abstract translation: 两件式夹紧元件包括两个单独的，即非整体的相对的第一和第二夹爪，形成横向敞开的腔以容纳销或棒状元件。 每个夹爪具有彼此对准的孔以容纳螺钉，其中枢转轴承布置成与所述腔相对，允许两个相对的夹爪彼此接触。 枢转轴承包括至少一组互补的部分圆柱形支承表面部分。 防旋转销在两个钳口构件之间延伸。

公开(公告)号：US07686837B2

公开(公告)日：2010-03-30

申请号：US10544323

申请日：2003-12-31

Applicant: André Gasser ,  Christian Lutz ,  Thomas Baumgartner ,  Andreas Bernhard

Inventor： André Gasser ,  Christian Lutz ,  Thomas Baumgartner ,  Andreas Bernhard

IPC: A61B17/58

CPC classification number: A61B17/8047 ,  A61B17/863

Abstract: The invention relates to an implantable orthopaedic device comprising a load-bearing element, such as a bone plate, for fixing elements, such as bone screws, that can be oriented polyaxially. The load-bearing element is equipped with at least one opening for the passage of the fixing elements. A two part insert is provided in the opening, the insert having an external form that complements the internal form of the receiving opening and permits the polyaxial rotation of the insert in the opening. The insert is equipped with a central bore for receiving the body of the fixing element. The first insert element part has a central inner hollow chamber, into which the second insert element part can be introduced. The first insert element is flexible or has at least one slit, in such a way that when the two insert elements are displaced axially in relation to one another, the first insert element in the plate can be expanded at least partially in order to block the position and alignment of the fixing element in the device in a polyaxial manner.

Abstract translation: 本发明涉及一种可植入矫形装置，其包括用于诸如骨螺钉的固定元件（例如骨板）的承载元件，其可以被多轴定向。 承载元件配备有用于固定元件通过的至少一个开口。 两个部分的插入件设置在开口中，插入件具有补充接收开口的内部形式的外部形式并且允许插入件在开口中的多轴旋转。 插入件配备有用于接收固定元件的主体的中心孔。 第一插入元件部分具有中心内部中空室，可以将第二插入元件部分引入该中空室。 第一插入元件是柔性的或具有至少一个狭缝，以这样的方式，当两个插入元件相对于彼此轴向移位时，板中的第一插入元件可以至少部分地膨胀以阻止 固定元件以多轴方式在装置中的位置和对准。

公开(公告)号：US07527626B2

公开(公告)日：2009-05-05

申请号：US10959340

申请日：2004-10-05

Applicant: Christian Lutz ,  Vinzenz Burgherr ,  Olivier Palefroy

Inventor： Christian Lutz ,  Vinzenz Burgherr ,  Olivier Palefroy

IPC: A61B17/56

CPC classification number: A61B17/60 ,  A61B17/6466 ,  A61B17/866

Abstract: An external fixation system has clamps, rods and pins having anti-magnetic core parts and a non-conductive sheath part covering essentially the exterior surfaces of the core part. The rods, pins and clamps are especially MRI safe for a patient when used in any frame configuration for fractures of the upper and lower extremities and pelvis wherein the usual MRI field parameters of a static field of 2 Tesla, a time-varying filed of max. 20 Tesla/sec and a specific absorption rate (SAR) of max. 0.4 Watts/kg averaged over the whole body of the patient apply.

Abstract translation: 外部固定系统具有夹具，杆和销，其具有防磁芯部分和基本上覆盖芯部分的外表面的非导电护套部分。 杆，针和夹具对于患者特别是MRI安全，当用于上肢和下肢和骨盆骨折的任何框架配置时，其中2特斯拉的静态场的通常的MRI场参数是最大的时变场 。 20特斯拉/秒，比吸收率（SAR）最大。 在整个病人身上平均0.4瓦/千克。

公开(公告)号：US07419965B2

公开(公告)日：2008-09-02

申请号：US10549799

申请日：2004-03-18

Applicant: Dieter Herrmann ,  Brigitte Heckl-Oestreicher ,  Christoph Mueller ,  Christian Lutz ,  Robert Voigt ,  William E. Bauta

Inventor： Dieter Herrmann ,  Brigitte Heckl-Oestreicher ,  Christoph Mueller ,  Christian Lutz ,  Robert Voigt ,  William E. Bauta

IPC: A61K31/70 ,  C07H19/19 ,  C07H19/20

CPC classification number: A61K31/7076 ,  C07H19/04 ,  C07H19/20

Abstract: The subject of the present invention is specific lipidesters of halogenated nucleotides of the following formula wherein R1, R2, R3, X and Y are defined as described herein and salts thereof, said compounds have anti-cancer properties; pharmaceutical compositions containing the compounds, a method of synthesizing the compounds, and a method of using the compounds for treating malignant tumors.

Abstract translation: 本发明的主题是下式的卤代核苷酸的具体脂质体，其中R 1，R 2，R 3，X和Y 定义为本文所述及其盐，所述化合物具有抗癌特性; 含有该化合物的药物组合物，合成化合物的方法以及使用该化合物治疗恶性肿瘤的方法。

公开(公告)号：US20080178702A1

公开(公告)日：2008-07-31

申请号：US12068100

申请日：2008-02-01

Applicant: Christian Lutz

Inventor： Christian Lutz

IPC: B62D1/18

CPC classification number: B62D1/184

Abstract: An adjustable steering column for a motor vehicle comprises a fixing device, in the opened state of which the steering column is adjustable in at least one displacement direction, and, in the closed state of which, the set position of the steering column is fixed and which for the displacement direction or for at least one of the displacement directions, for fixing the set position comprises at least one securement part which includes at least one toothing with teeth, and at least one counter-securement part, which includes at least one counter toothing, with teeth. Viewed in a cross section through the teeth of the securement part and of the counter-securement part, wherein the plane of this cross section is oriented parallel to the displacement direction and parallel to the opening direction, both side flanks of the teeth of the securement part and of the counter-securement part in the closed state of the fixing device form, at least in a section of their extent, inclination angles of less than 20°, preferably less than 12°, with the opening direction.

Abstract translation: 用于机动车辆的可调节转向柱包括定位装置，处于打开状态，转向柱在至少一个位移方向上可调节，并且在关闭状态下，转向柱的设定位置是固定的，并且 对于用于固定设定位置的位移方向或位移方向中的至少一个位移方向，包括至少一个固定部件，该固定部件包括至少一个具有齿的齿部，以及至少一个反紧固部件，其包括至少一个计数器 齿齿，牙齿。 在通过固定部分和相对固定部分的齿的横截面中观察，其中该横截面的平面平行于位移方向定向并平行于打开方向，固定件的齿的两个侧面 在固定装置的关闭状态下的反紧固部分的部分和相对固定部分形成至少在它们的程度的一部分中，与打开方向小于20°，优选小于12°的倾斜角。

公开(公告)号：US20070288022A1

公开(公告)日：2007-12-13

申请号：US11784773

申请日：2007-04-09

Applicant: Christian Lutz

Inventor： Christian Lutz

IPC: A61B17/80

CPC classification number: A61B17/8052 ,  A61B17/8057

Abstract: A bone reconstruction plate is formed of a longitudinally extending plate defining one or more attachment bores. Within one or more of the attachment bores, one or more ridges are disposed around at least a portion of the interior of the one or more attachment bores, whereby the one or more ridges operate to provide increased resistance to fatigue.

Abstract translation: 骨重建板由限定一个或多个附接孔的纵向延伸的板形成。 在一个或多个附接孔内，一个或多个脊设置在一个或多个附接孔的内部的至少一部分周围，由此一个或多个脊操作以提供增加的抗疲劳性。

公开(公告)号：US20060116680A1

公开(公告)日：2006-06-01

申请号：US10999668

申请日：2004-11-30

Applicant: Stefan Kugler ,  Andre Gasser ,  Christian Lutz

Inventor： Stefan Kugler ,  Andre Gasser ,  Christian Lutz

IPC: A61F2/30

CPC classification number: A61B17/92 ,  A61B17/8047 ,  Y10T29/5393

Abstract: An extractor device is provided to extract an insert to be used with a bone connection element such as a bone plate having at least one opening for a bone screw used with said insert. The extractor device has an outer hollow sleeve having proximal abutment surface being able to engage a surface portion of the bone connection element, and an inner bar having a diameter enabling the insertion of the bar into the hollow sleeve. The bar has a threaded leading end to engage the thread of the insert to be extracted. The hollow sleeve has an inner thread and the inner bar has an outer threaded element for engaging the inner thread of the hollow sleeve. The outer threaded element is positioned with respect to the bar in a longitudinal position to enable the thread at its leading end to extend beyond the proximal abutment surface of the sleeve to be threaded into the insert.

Abstract translation: 提供提取装置以提取与骨连接元件（例如骨板）一起使用的插入物，所述骨连接元件具有用于与所述插入件一起使用的骨螺钉的至少一个开口。 提取器装置具有外部中空套筒，其具有能够接合骨连接元件的表面部分的近端邻接表面和具有能够将杆插入中空套筒的直径的内杆。 该杆具有螺纹的前端以与插入件的螺纹接合以被拔出。 中空套管具有内螺纹，并且内杆具有用于接合中空套筒的内螺纹的外螺纹元件。 外螺纹元件相对于杆在纵向位置定位，以使其在其前端处的螺纹能够延伸超过套筒的近端邻接表面以进入插入件。

公开(公告)号：US06800032B2

公开(公告)日：2004-10-05

申请号：US10465725

申请日：2003-06-20

Applicant: Gerhard Heutschi ,  Christian Lutz

Inventor： Gerhard Heutschi ,  Christian Lutz

IPC: F16D333

CPC classification number: F16D3/32 ,  F16C11/0652 ,  Y10S464/905 ,  Y10T403/32713 ,  Y10T403/32737

Abstract: A steering shaft double joint for motor vehicles includes two shaft ends each connected nonrotatably in a respective first and second joint. The first and second joints are operatively arranged in a housing to movably mount the two shaft ends. A ball joint is arranged between the first and second joints, wherein the ball joint includes a ball arranged on one of the shaft ends and a receptacle arranged on the other shaft end. The ball is arranged in the receptacle, and is rotatable around the midpoint of the ball and slidably movable in a direction of a shaft axis of the other shaft end. A plastic sliding guide is disposed between the receptacle and the ball, and a spring surrounds radially the plastic sliding guide and is disposed radially between the plastic sliding guide and the receptacle.

Abstract translation: 用于机动车辆的转向轴双关节包括两个轴端，每个轴端在相应的第一和第二关节中不可旋转地连接。 第一和第二接头可操作地布置在壳体中以可移动地安装两个轴端。 球接头设置在第一和第二接头之间，其中球窝接头包括布置在轴端中的一个上的球和设置在另一轴端的接头。 该球被布置在该容器中，并且能够围绕该球的中点旋转并且可沿另一个轴端的轴的方向可滑动地移动。 塑料滑动导轨设置在容器和球之间，弹簧围绕塑料滑动导轨径向包围，并且径向设置在塑料滑动导轨和容器之间。