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公开(公告)号：US07713624B2
公开(公告)日：2010-05-11
申请号：US10554765
申请日：2004-04-29
CPC分类号： C09K11/7777 , C09K11/02 , G01N21/6428 , G01N2021/6432 , Y10S977/773 , Y10S977/834 , Y10S977/89 , Y10S977/896 , Y10S977/90 , Y10T428/25 , Y10T428/256 , Y10T428/2991
摘要： Luminescent inorganic nanoparticles comprising: (a) a core made from a first metal salt or oxide being surrounded by (b) a shell made from a second metal salt or oxide being luminescent and having non-semiconductor properties. These nanoparticles can be advantageously used in (fluorescence) resonance energy transfer ((F)RET)-based bioassays in view of their higher (F)RET efficiency.
摘要翻译： 发光无机纳米颗粒包括：（a）由第一金属盐或氧化物制成的芯被（b）由发光的第二金属盐或氧化物制成并具有非半导体性质的壳包围。 考虑到它们的更高（F）RET效率，这些纳米颗粒可以有利地用于（荧光）共振能量转移（（F）RET）的生物测定中。
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公开(公告)号：US20070087195A1
公开(公告)日：2007-04-19
申请号：US10554765
申请日：2004-04-29
CPC分类号： C09K11/7777 , C09K11/02 , G01N21/6428 , G01N2021/6432 , Y10S977/773 , Y10S977/834 , Y10S977/89 , Y10S977/896 , Y10S977/90 , Y10T428/25 , Y10T428/256 , Y10T428/2991
摘要： The present invention relates to luminescent inorganic nanoparticles comprising (a) a core made from a first metal salt or oxide being surrounded by (b) a shell made from a second metal salt or oxide being luminescent and having non-semiconductor properties. These particles can be advantageously used in (fluorescence) resonance energy transfer ((F)RET)-based bioassays in view of their higher (F)RET efficiency.
摘要翻译： 本发明涉及发光无机纳米颗粒，其包含（a）由第一金属盐或氧化物制成的芯，被（b）由发光的第二金属盐或氧化物制成的壳体包围，并具有非半导体性质。 鉴于它们的（F）RET效率更高，这些颗粒可以有利地用于（荧光）共振能量转移（（F）RET）的生物测定中。
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公开(公告)号：US07135561B2
公开(公告)日：2006-11-14
申请号：US10236542
申请日：2002-09-06
CPC分类号： C12N7/00 , A61K2039/5254 , A61K2039/53 , C12N2770/24361 , C12N2770/24362
摘要： The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.
摘要翻译： 本发明属于动物健康领域，特别是牛病毒性腹泻病毒（BVDV）。 本发明提供感染性BVDV克隆和产生所述BVDV克隆的方法。 本发明还涉及减毒所述克隆，减毒BVDV克隆和包含所述减毒克隆的疫苗的方法。
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公开(公告)号：US07344895B2
公开(公告)日：2008-03-18
申请号：US10540168
申请日：2003-12-06
申请人： Burkhard Köhler , Kerstin Bohmann , Werner Hoheisel , Markus Haase , Stefan Haubold , Christiane Meyer , Thorsten Heidelberg
发明人： Burkhard Köhler , Kerstin Bohmann , Werner Hoheisel , Markus Haase , Stefan Haubold , Christiane Meyer , Thorsten Heidelberg
IPC分类号： G01N33/543 , G01N37/00 , G01N33/24
CPC分类号： C09K11/7797 , C07F9/4009 , C09K11/7708 , C09K11/7712 , C09K11/7723 , C09K11/7725 , C09K11/7733 , C09K11/7734 , C09K11/7736 , C09K11/7737 , C09K11/7739 , C09K11/774 , C09K11/7741 , C09K11/7776 , C09K11/778 , C09K11/7792 , C09K11/7794 , Y10S977/81 , Y10S977/811 , Y10T436/13
摘要： A process for synthesizing nanoparticles, in particular metal salt nanoparticles. To the synthesis mixture is added a modifying reagent which binds, by means of a first functional group, to the nanoparticle surface and which carries a second functional group for binding to molecules which are specifically selected in dependence on the subsequent use of the nanoparticles. This dispenses with a postsynthetic, separate, application-specific modification step. A new substance class, the pentaalkyl iminobis(methylenephosphono)carboxylates, are particularly suitable for this purpose. These modifying reagents permit the nanoparticles to grow in a specifically controlled manner and, at the same time, modify the surface of the growing nanoparticles, (in-situ) during the synthesis, such that the particles can be very readily dissolved in a large number of solvents and carry functional groups for coupling on molecules, resulting in the particles having, immediately after having been synthesized, a certain all-round usability.
摘要翻译： 一种合成纳米颗粒的方法，特别是金属盐纳米颗粒。 向合成混合物中加入一种修饰试剂，其通过第一官能团结合到纳米颗粒表面，并且其携带第二官能团以结合分子，其依赖于随后使用纳米颗粒而被特别选择。 这不需要一个合成后的，独立的应用程序特定的修改步骤。 新物质类，五烷基亚氨基双（亚甲基膦酰基）羧酸酯特别适合于此目的。 这些改性试剂允许纳米颗粒以特定控制的方式生长，并且同时在合成期间（原位）修饰生长的纳米颗粒的表面，使得颗粒可以非常容易地溶解在大量中 的溶剂并携带用于在分子上偶联的官能团，导致颗粒在合成后立即具有一定的全面可用性。
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公开(公告)号：US08337804B2
公开(公告)日：2012-12-25
申请号：US10554903
申请日：2004-04-28
申请人： Thorsten Heidelberg , Christiane Meyer , Imke Kühl
发明人： Thorsten Heidelberg , Christiane Meyer , Imke Kühl
IPC分类号： C01G31/02
CPC分类号： B82Y30/00 , C01B25/45 , C01G31/00 , C01G31/006 , C01P2002/54 , C01P2002/84 , C01P2004/52 , C01P2004/64 , C01P2006/60 , C09K11/7794 , C09K11/7795
摘要： The present invention relates to a method for the production of nanoparticulate metal(III) vanadates or vanadate/phosophate mixed crystals, comprising the reaction in a reaction medium of a reactive vanadate source and optionally a phosphate source dissolvable or dispersible in the reaction medium and of a reactive metal(III) salt dissolvable or dispersible in the reaction medium under heating, wherein the reaction medium contains water and a polyol in a volume ratio of 20/80 to 90/10, and the particles thereby obtained. The synthesis provides a high yield of metal(III) vanadate or vanadate/phosphate having a narrow particle size distribution. Doped embodiments thereof are distinguished by excellent luminescence properties.
摘要翻译： 本发明涉及一种生产纳米颗粒金属（III）钒酸盐或钒酸盐/磷酸盐混合晶体的方法，其包括在反应性钒酸盐源的反应介质中和任选地可溶于或可分散在反应介质中的磷酸盐源的反应，以及 在加热下可溶于或分散在反应介质中的活性金属（III）盐，其中反应介质含有体积比为20/80至90/10的水和多元醇，由此得到的颗粒。 合成提供了高产率的具有窄粒度分布的钒酸盐或钒酸盐/磷酸盐。 其掺杂的实施方案由优异的发光特性来区分。
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公开(公告)号：US07288239B2
公开(公告)日：2007-10-30
申请号：US10535864
申请日：2003-11-19
CPC分类号： C09C1/02 , A61K49/0404 , A61K49/0423 , B82Y5/00 , B82Y30/00 , C01F5/40 , C01F11/46 , C01F11/462 , C01P2002/52 , C01P2002/84 , C01P2004/64 , C01P2006/22 , Y10S977/773 , Y10S977/775
摘要： The invention relates to synthesis of nanoparticles, in particular to methods for producing nanoparticles with networks consisting of Z sulphate (Z=magnesium (Mg), calcium (Ca), strontium (Sr), barium (Ba) or the binary mixtures thereof). The inventive method consists in synthesising the nanoparticles by crystal growth from an ion Z source and a sulphate ion source in a liquid phase mixture. The invention produces Z sulphate nanoparticles having a small diameter and uniformly dispersible in water or other solvents in a simple way. Co-ordinating solvents like glycerine, glycol ethylene and other polyethylene glycols, polyalcohols or dimethylsulphoxide (DMSO) are used for the synthesis mixture.
摘要翻译： 本发明涉及纳米颗粒的合成，特别涉及用Z硫酸盐（Z =镁（Mg），钙（Ca），锶（Sr），钡（Ba）或其二元混合物）组成的网络制备纳米颗粒的方法。 本发明的方法包括通过在液相混合物中从离子Z源和硫酸根离子源的晶体生长合成纳米颗粒。 本发明以简单的方式产生具有小直径且均匀分散在水或其它溶剂中的硫酸锌纳米颗粒。 将合成溶剂如甘油，乙二醇乙烯和其它聚乙二醇，多元醇或二甲基亚砜（DMSO）用于合成混合物。
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公开(公告)号：US20070148082A1
公开(公告)日：2007-06-28
申请号：US10554903
申请日：2004-04-28
申请人： Thorsten Heidelberg , Christiane Meyer , Imke Kuhl
发明人： Thorsten Heidelberg , Christiane Meyer , Imke Kuhl
IPC分类号： C01G31/02
CPC分类号： B82Y30/00 , C01B25/45 , C01G31/00 , C01G31/006 , C01P2002/54 , C01P2002/84 , C01P2004/52 , C01P2004/64 , C01P2006/60 , C09K11/7794 , C09K11/7795
摘要： The present invention relates to a method for the production of nanoparticulate metal(III) vanadates or vanadate/phosophate mixed crystals, comprising the reaction in a reaction medium of a reactive vanadate source and optionally a phosphate source dissolvable or dispersible in the reaction medium and of a reactive metal(III) salt dissolvable or dispersible in the reaction medium under heating, wherein the reaction medium contains water and a polyol in a volume ratio of 20/80 to 90/10, and the particles thereby obtained. The synthesis provides a high yield of metal(III) vanadate or vanadate/phosphate having a narrow particle size distribution. Doped embodiments thereof are distinguished by excellent luminescence properties.
摘要翻译： 本发明涉及一种生产纳米颗粒金属（III）钒酸盐或钒酸盐/磷酸盐混合晶体的方法，其包括在反应性钒酸盐源的反应介质中和任选地可溶于或可分散在反应介质中的磷酸盐源的反应，以及 在加热下可溶于或分散在反应介质中的活性金属（III）盐，其中反应介质含有体积比为20/80至90/10的水和多元醇，由此得到的颗粒。 合成提供了高产率的具有窄粒度分布的钒酸盐或钒酸盐/磷酸盐。 其掺杂的实施方案由优异的发光特性来区分。
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公开(公告)号：US20060133987A1
公开(公告)日：2006-06-22
申请号：US10535864
申请日：2003-11-19
IPC分类号： C01F11/46
CPC分类号： C09C1/02 , A61K49/0404 , A61K49/0423 , B82Y5/00 , B82Y30/00 , C01F5/40 , C01F11/46 , C01F11/462 , C01P2002/52 , C01P2002/84 , C01P2004/64 , C01P2006/22 , Y10S977/773 , Y10S977/775
摘要： The invention relates to synthesis of nanoparticles, in particular to methods for producing nanoparticles with a net-works consisting of Z sulphate (Z=magnesium (Mg), calcium (Ca), strontium (Sr), barium (Ba) or the binary mixtures thereof). The inventive method consists in synthesising the nanoparticles by crystal growth from an ion Z source and a sulphate ion source in a synthesis liquid phase mixture. The aim of said invention is to produce in a simple way barium sulphate nanoparticles having a small diameter, said particles being uniformly dispersed in water or other solvents. For this purpose, co-ordinating solvents like glycerine, glycol ethylene and other polyethylene glycols, polyalcohols or dimethylsulphoxide (DMSO) are used for the synthesis mixture. In the preferred embodiment, barium is used in the form of chloride and the sulphate source in the form of tetrabutylammonium hydrogen sulphate. Other metallic dopants can be eventually integrated in the nanoparticles network. When the synthesis is also used in the form of chloride.
摘要翻译： 本发明涉及纳米颗粒的合成，特别涉及用Z硫酸盐（Z =镁（Mg），钙（Ca），锶（Sr），钡（Ba）或二元混合物 ）。 本发明的方法包括通过在合成液相混合物中从离子Z源和硫酸根离子源的晶体生长合成纳米颗粒。 本发明的目的是以简单的方式生产具有小直径的硫酸钡纳米颗粒，所述颗粒均匀分散在水或其它溶剂中。 为此，将合成溶剂如甘油，二醇乙烯和其它聚乙二醇，多元醇或二甲基亚砜（DMSO）用于合成混合物。 在优选的实施方案中，钡以氯化物的形式使用，硫酸盐源以四丁基硫酸氢铵的形式使用。 其他金属掺杂剂可以最终集成在纳米粒子网络中。 当合成也以氯化物的形式使用时。
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公开(公告)号：US20120201850A1
公开(公告)日：2012-08-09
申请号：US13364259
申请日：2012-02-01
CPC分类号： C12N7/00 , A61K2039/5254 , A61K2039/53 , C12N2770/24361 , C12N2770/24362
摘要： The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.
摘要翻译： 本发明属于动物健康领域，特别是牛病毒性腹泻病毒（BVDV）。 本发明提供感染性BVDV克隆和产生所述BVDV克隆的方法。 本发明还涉及减毒所述克隆，减毒BVDV克隆和包含所述减毒克隆的疫苗的方法。
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10.发明授权Luminescent core/shell nanoparticles comprising a luminescent core and method of making thereof 有权包含发光核心的发光核/壳纳米颗粒及其制造方法公开(公告)号：US07651771B2
公开(公告)日：2010-01-26
申请号：US10554896
申请日：2004-04-29
申请人： Christiane Meyer , Markus Haase
发明人： Christiane Meyer , Markus Haase
IPC分类号： B32B5/16
CPC分类号： C09K11/7777 , C09K11/025 , C09K11/7741 , Y10S977/773 , Y10S977/834 , Y10S977/89 , Y10S977/896 , Y10S977/90 , Y10T428/2991 , Y10T428/2993
摘要： The present invention relates to Luminescent nanoparticles comprising (a) a core made from a luminescent metal salt selected from phosphates, sulfates or fluorides, being surrounded by (b) a shell made from a metal salt or oxide capable of preventing or reducing energy transfer from the core after its electronic excitation to the surface of the nanoparticle, e.g. a shell made from a non-luminescent metal salt or oxide, which are characterized by higher quantum yields and can be used in various fields including light generation and security marking.
摘要翻译： 本发明涉及发光纳米颗粒，其包含（a）由选自磷酸盐，硫酸盐或氟化物的发光金属盐制成的核心，被（b）由金属盐或氧化物制成的壳体包围，所述金属盐或氧化物能够预防或减少从 其核心在其电子激发到纳米颗粒的表面之后，例如 由非发光金属盐或氧化物制成的外壳，其特征在于较高的量子产率，并可用于包括发光和安全标记在内的各种领域。
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