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    Sp35 antibodies and uses thereof
    1.
    发明授权
    Sp35 antibodies and uses thereof 有权
    Sp35抗体及其用途

    公开(公告)号：US08609407B2

    公开(公告)日：2013-12-17

    申请号：US13356413

    申请日：2012-01-23

    申请人： Sha Mi ,  R. Blake Pepinsky ,  Zhaohui Shao ,  Ellen A. Garber ,  Steven D. Miklasz ,  Christilyn Graff

    发明人： Sha Mi ,  R. Blake Pepinsky ,  Zhaohui Shao ,  Ellen A. Garber ,  Steven D. Miklasz ,  Christilyn Graff

    IPC分类号： C12N5/16 ,  C12N15/63 ,  C07H21/04

    CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

    摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

    摘要翻译： 内源性Sp35是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成的负调节因子。 阻断内源性Sp35功能的分子，这种抗Sp35抗体可以用作治疗神经元和少突胶质细胞功能障碍的治疗剂。 本发明提供对Sp35特异性的抗体，以及使用抗体作为内源性Sp35功能拮抗剂的方法。 本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。 本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗Sp35抗体。

    Composition comprising antibodies to LINGO or fragments thereof
    2.
    发明授权
    Composition comprising antibodies to LINGO or fragments thereof 有权
    组合物，其包含LINGO抗体或其片段

    公开(公告)号：US08425910B2

    公开(公告)日：2013-04-23

    申请号：US13243795

    申请日：2011-09-23

    申请人： Sha Mi ,  R. Blake Pepinsky ,  Christilyn Graff

    发明人： Sha Mi ,  R. Blake Pepinsky ,  Christilyn Graff

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6849 ,  A61K47/6879 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/01

    摘要： Endogenous LINGO-1 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous LINGO-1 function, such anti-LINGO-1 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for LINGO-1, and methods of using such antibodies as antagonists of endogenous LINGO-1 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-LINGO-1 antibody.

    摘要翻译： 内源性LINGO-1是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成的负调节因子。 阻断内源性LINGO-1功能的分子，如抗LINGO-1抗体可用作治疗神经元和少突胶质细胞功能障碍的治疗剂。 本发明提供对LINGO-1特异性的抗体，以及使用这些抗体作为内源性LINGO-1功能的拮抗剂的方法。 本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。 本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗LINGO-1抗体。

    Composition comprising antibodies to LINGO or fragments thereof
    3.
    发明授权
    Composition comprising antibodies to LINGO or fragments thereof 有权
    组合物，其包含LINGO抗体或其片段

    公开(公告)号：US08058406B2

    公开(公告)日：2011-11-15

    申请号：US12500472

    申请日：2009-07-09

    申请人： Sha Mi ,  R. Blake Pepinsky ,  Christilyn Graff

    发明人： Sha Mi ,  R. Blake Pepinsky ,  Christilyn Graff

    IPC分类号： C07K16/28 ,  A61K39/395 ,  C12P21/08

    CPC分类号： C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6849 ,  A61K47/6879 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/01

    摘要： Endogenous LINGO-1 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous LINGO-1 function, such anti-LINGO-1 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for LINGO-1, and methods of using such antibodies as antagonists of endogenous LINGO-1 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-LINGO-1 antibody.

    摘要翻译： 内源性LINGO-1是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成的负调节因子。 阻断内源性LINGO-1功能的分子，如抗LINGO-1抗体可用作治疗神经元和少突胶质细胞功能障碍的治疗剂。 本发明提供对LINGO-1特异性的抗体，以及使用这些抗体作为内源性LINGO-1功能的拮抗剂的方法。 本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。 本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗LINGO-1抗体。

    SP35 antibodies and uses thereof
    4.
    发明授权
    SP35 antibodies and uses thereof 失效
    SP35抗体及其用途

    公开(公告)号：US08551476B2

    公开(公告)日：2013-10-08

    申请号：US11892036

    申请日：2007-08-17

    申请人： Sha Mi ,  R. Blake Pepinsky ,  Zhaohui Shao ,  Christilyn Graff

    发明人： Sha Mi ,  R. Blake Pepinsky ,  Zhaohui Shao ,  Christilyn Graff

    IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K35/30

    CPC分类号： A61K47/48538 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2803 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/14

    摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (Negative Regulator). Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

    摘要翻译： 内源性Sp35是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成（负调节因子）的负调节因子。 阻断内源性Sp35功能的分子，这种抗Sp35抗体可以用作治疗神经元和少突胶质细胞功能障碍的治疗剂。 本发明提供对Sp35特异性的抗体，以及使用抗体作为内源性Sp35功能拮抗剂的方法。 本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。 本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗Sp35抗体。

    Anti-IGR-1R antibodies and uses thereof
    5.
    发明授权
    Anti-IGR-1R antibodies and uses thereof 有权
    抗IGR-1R抗体及其用途

    公开(公告)号：US08147829B2

    公开(公告)日：2012-04-03

    申请号：US12559415

    申请日：2009-09-14

    申请人： Kandasamy Hariharan ,  Scott Glaser ,  Ellen Garber ,  Christilyn Graff ,  Christopher L. Reyes ,  Stephen Demarest

    发明人： Kandasamy Hariharan ,  Scott Glaser ,  Ellen Garber ,  Christilyn Graff ,  Christopher L. Reyes ,  Stephen Demarest

    IPC分类号： A61K39/395 ,  C07K16/00

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00

    摘要： The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

    摘要翻译： 本发明涉及结合胰岛素样生长因子受体-1（IGF-1R）的抗体及其用途，特别是癌症的诊断和治疗。 提供了抑制IGF-1R介导的原始存活和肿瘤增殖途径的特异性人和鼠单克隆抗体及其变体，片段及其衍生物。 还提供阻断配体，胰岛素样生长因子1（IGF-1）和胰岛素样生长因子2（IGF-2）与IGF-1R结合的能力的特异性人和鼠单克隆抗体，以及片段， 这些抗体的变体和衍生物。 本发明还包括编码上述抗体或其片段，变体或衍生物的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还包括使用本发明的抗体诊断和治疗癌症的方法。

    RON antibodies and uses thereof
    7.
    发明申请
    RON antibodies and uses thereof 审中-公开
    RON抗体及其用途

    公开(公告)号：US20090226442A1

    公开(公告)日：2009-09-10

    申请号：US12320296

    申请日：2009-01-22

    申请人： Heather Huet ,  Veronique Bailly ,  Ellen Garber ,  Christilyn Graff ,  Steven Miklasz

    发明人： Heather Huet ,  Veronique Bailly ,  Ellen Garber ,  Christilyn Graff ,  Steven Miklasz

    IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K17/00 ,  C12N9/96 ,  C12N7/00 ,  C07H21/04 ,  C12N5/00 ,  C12P21/04

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/76

    摘要： The invention relates to antibodies which bind to RON (receptor d'origine nantais, MST1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific antibodies which inhibit RON-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific antibodies which block the ability of the ligand, MSP to bind to RON, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

    摘要翻译： 本发明涉及结合RON（受体Nantais，MST1R）的抗体及其用途，特别是癌症的诊断和治疗。 提供抑制RON介导的原始存活和肿瘤增殖途径的特异性抗体及其变体，片段及其衍生物。 还提供阻断配体，MSP结合RON的能力的特异性抗体，以及这些抗体的片段，变体和衍生物。 本发明还包括编码上述抗体或其片段，变体或衍生物的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还包括使用本发明的抗体诊断和治疗癌症的方法。

    Sp35 Antibodies and Uses Thereof
    10.
    发明申请
    Sp35 Antibodies and Uses Thereof 有权
    Sp35抗体及其用途

    公开(公告)号：US20120190070A1

    公开(公告)日：2012-07-26

    申请号：US13356413

    申请日：2012-01-23

    申请人： Sha MI ,  R. Blake Pepinsky ,  Zhaohui Shao ,  Ellen A. Garber ,  Steven D. Miklasz ,  Christilyn Graff

    发明人： Sha MI ,  R. Blake Pepinsky ,  Zhaohui Shao ,  Ellen A. Garber ,  Steven D. Miklasz ,  Christilyn Graff

    IPC分类号： C12P21/02 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13

    CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

    摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

    摘要翻译： 内源性Sp35是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成的负调节因子。 阻断内源性Sp35功能的分子，这种抗Sp35抗体可以用作治疗神经元和少突胶质细胞功能障碍的治疗剂。 本发明提供对Sp35特异性的抗体，以及使用抗体作为内源性Sp35功能拮抗剂的方法。 本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。 本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗Sp35抗体。