公开(公告)号：US08475518B2

公开(公告)日：2013-07-02

申请号：US11776458

申请日：2007-07-11

申请人： Daniel L. Cox ,  Christopher Feezor

发明人： Daniel L. Cox ,  Christopher Feezor

IPC分类号： A61F2/06

CPC分类号： A61F2/89 ,  A61F2/848 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2220/005 ,  A61F2230/0013 ,  A61F2230/0054

摘要： A stent for implantation in a body lumen for protecting from rupture a fibrous cap in order to treat vulnerable plaque. One embodiment of the stent achieves staged expansion through stronger and weaker circumferential regions, and includes optional anchors positioned at the circumferential transition between the stronger and weaker regions. During the first stage expansion, the weaker region expands moving the anchors laterally apart. The anchors straddle the fibrous cap and embed into the vessel wall. The second stage expansion of the stent exerts gentler stresses by the weaker region against the fibrous cap while the stronger region exerts greater stresses on the remainder of the vessel wall to open the vessel.

公开(公告)号：US20090286761A1

公开(公告)日：2009-11-19

申请号：US12191209

申请日：2008-08-13

申请人： Jin Cheng ,  Stephen Dugan ,  Gordon Stewart ,  Gina Zhang ,  Nancy Kirsten ,  Paul Consigny ,  Christopher Feezor ,  Gene Park ,  Wouter Roorda ,  Syed F.A. Hossainy

发明人： Jin Cheng ,  Stephen Dugan ,  Gordon Stewart ,  Gina Zhang ,  Nancy Kirsten ,  Paul Consigny ,  Christopher Feezor ,  Gene Park ,  Wouter Roorda ,  Syed F.A. Hossainy

IPC分类号： A61K31/56 ,  A61P7/00

CPC分类号： A61L31/16 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61K31/4745 ,  A61K31/56 ,  A61K31/573 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/222 ,  A61L2300/416 ,  A61L2300/45 ,  A61K2300/00

摘要： A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 μg, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).

摘要翻译： 提供了一种药物递送系统，其包括至少100杯依维莫司和氯倍他索，使得依维莫司与氯倍他索的比例至少为10：1（w / w），依维莫司的重量比为至少10倍 氯倍他索 该系统可以是支架。 还提供了治疗血管的再狭窄或易损斑块的方法，所述方法包括向患者局部施用选自雷帕霉素（西罗莫司），Biolimus A9，deforolimus，AP23572，他克莫司，替西罗莫司，吡美莫司， 40-（2-羟基）乙基雷帕霉素（依维莫司），40-O-（3-羟基）丙基雷帕霉素，40-O- [2-（2-羟基）乙氧基]乙基雷帕霉素，40- O-四唑基雷帕霉素和40-表 - （N1-四唑基）雷帕霉素，并且对患者局部施用由氯倍他索组成的第二药物，其中局部施用的第一药物的最小量为100杯，其中 第二种药物的第一种药物例如为10：1〜100：1（w / w）。

公开(公告)号：US08586069B2

公开(公告)日：2013-11-19

申请号：US11322282

申请日：2005-12-29

申请人： Gordon Stewart ,  Gina Zhang ,  Nancy Kirsten ,  Paul Consigny ,  Stephen Dugan ,  Gene Park ,  Christopher Feezor ,  Wouter Roorda ,  Syed Faiyaz Ahmed Hossainy

发明人： Gordon Stewart ,  Gina Zhang ,  Nancy Kirsten ,  Paul Consigny ,  Stephen Dugan ,  Gene Park ,  Christopher Feezor ,  Wouter Roorda ,  Syed Faiyaz Ahmed Hossainy

IPC分类号： A61F13/00 ,  A61F2/00

CPC分类号： A61K31/4745 ,  A61F2250/0067 ,  A61K31/436 ,  A61K31/573 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61K2300/00

摘要： Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.

摘要翻译： 提供了药物递送系统，例如具有抗增殖剂如依维莫司的药物递送支架和抗炎剂如氯倍他索。 还公开了治疗血管损伤如再狭窄或易损斑块的方法。

公开(公告)号：US08435279B2

公开(公告)日：2013-05-07

申请号：US11152951

申请日：2005-06-14

申请人： Dagmar Beyerlein ,  Christopher Feezor ,  Karim Osman ,  Denise Horrilleno Burns ,  Carla Rosa Pienknagura ,  Barbara Stamberg

发明人： Dagmar Beyerlein ,  Christopher Feezor ,  Karim Osman ,  Denise Horrilleno Burns ,  Carla Rosa Pienknagura ,  Barbara Stamberg

IPC分类号： A61F2/06

CPC分类号： A61F2/95 ,  A61F2/966

摘要： A delivery system for a medical device. The delivery system comprises an inner member, a retractable sheath disposed over the inner member and being slideable over the inner member, and a retraction member coupled to the retractable sheath and disposed at least in portion within the retractable sheath, the retraction member being slideable over the inner member. An axial movement of the retraction member retracts or actuates the retractable member.

摘要翻译： 用于医疗器械的输送系统。 输送系统包括内部构件，设置在内部构件上方并可在内部构件上滑动的可缩回护套，以及联接到可缩回护套并且至少部分地设置在可缩回护套内的缩回构件，缩回构件可滑动 内部成员。 缩回构件的轴向运动缩回或致动可伸缩构件。

公开(公告)号：US07485143B2

公开(公告)日：2009-02-03

申请号：US10295714

申请日：2002-11-15

申请人： William E. Webler ,  Gregory Mathew Hyde ,  Christopher Feezor ,  Daniel L. Cox

发明人： William E. Webler ,  Gregory Mathew Hyde ,  Christopher Feezor ,  Daniel L. Cox

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61F2/91 ,  A61F2002/828 ,  A61F2250/001 ,  Y10T24/39

摘要： A medical device for treating a defective heart valve. The medical device comprises a distal anchoring member for disposing in a blood vessel. A proximal anchoring member for disposing in or at an entrance of the blood vessel. A telescoping assembly coupling at a first end to the distal anchoring member and at a second end to the proximal anchoring member. The telescoping assembly is deployable into the blood vessel. The telescoping assembly reduces a distance between the distal anchoring member and the proximal anchoring member, wherein the telescoping assembly comprises of at least two members capable of sliding into each other giving the telescoping assembly adjustable lengths.

摘要翻译： 一种用于治疗有缺陷心脏瓣膜的医疗装置。 医疗装置包括用于设置在血管中的远侧锚定构件。 用于设置在血管入口处或入口处的近端锚定构件。 伸缩组件在第一端处联接到远侧锚固构件，并且在第二端处联接到近侧锚定构件。 伸缩组件可展开到血管中。 伸缩组件减小了远侧锚固构件和近侧锚固构件之间的距离，其中伸缩组件包括能够相互滑动的至少两个构件，其给予伸缩组件可调长度。

公开(公告)号：US20080015685A1

公开(公告)日：2008-01-17

申请号：US11776458

申请日：2007-07-11

申请人： Daniel Cox ,  Christopher Feezor

发明人： Daniel Cox ,  Christopher Feezor

IPC分类号： A61F2/90

CPC分类号： A61F2/89 ,  A61F2/848 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2220/005 ,  A61F2230/0013 ,  A61F2230/0054

摘要： A stent for implantation in a body lumen for protecting from rupture a fibrous cap in order to treat vulnerable plaque. One embodiment of the stent achieves staged expansion through stronger and weaker circumferential regions, and includes optional anchors positioned at the circumferential transition between the stronger and weaker regions. During the first stage expansion, the weaker region expands moving the anchors laterally apart. The anchors straddle the fibrous cap and embed into the vessel wall. The second stage expansion of the stent exerts gentler stresses by the weaker region against the fibrous cap while the stronger region exerts greater stresses on the remainder of the vessel wall to open the vessel.

摘要翻译： 用于植入体腔中的支架，用于防止纤维帽破裂以便治疗易损斑块。 支架的一个实施例通过更强和更弱的圆周区域实现分阶段膨胀，并且包括位于较强和较弱区域之间的圆周过渡处的可选锚定件。 在第一阶段的扩张期间，较弱的区域使得锚固体横向分开。 锚固件跨过纤维帽并嵌入血管壁。 支架的第二阶段膨胀对弱纤维帽施加较弱的应力，而较强的区域对容器壁的其余部分施加更大的应力以打开容器。

公开(公告)号：US07572286B1

公开(公告)日：2009-08-11

申请号：US10144553

申请日：2002-05-13

申请人： Yung-Ming Chen ,  Christopher Feezor ,  Deborah Kilpatrick ,  Santosh Prabhu

发明人： Yung-Ming Chen ,  Christopher Feezor ,  Deborah Kilpatrick ,  Santosh Prabhu

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/91558 ,  A61F2220/005 ,  A61F2250/0067

摘要： An intravascular stent assembly for implantation in a body lumen, such as a coronary artery, is designed to treat a lesion with vulnerable plaque by reducing the fibrous cap stresses. A polymeric sleeve having first and second ends interconnects a first metallic stent and a second metallic stent. The first end is bonded to a distal end region of the first stent and the second end to a proximal end region of the second stent. The polymeric sleeve can be loaded with a therapeutic drug or agent to further control local thrombosis and/or induce healing if the plaque fibrous cap ruptures during or after implantation. Methods of making an intravascular stent assembly for the treatment of vulnerable plaque are also provided.

摘要翻译： 用于植入体腔（例如冠状动脉）中的血管内支架装置设计成通过减少纤维帽应力来治疗具有易损斑块的病变。 具有第一和第二端的聚合物套管互连第一金属支架和第二金属支架。 第一端部结合到第一支架的远端区域，第二端部连接到第二支架的近端区域。 如果斑块纤维帽在植入期间或之后破裂，则聚合物套管可以装载有治疗药物或药剂以进一步控制局部血栓形成和/或诱导愈合。 还提供了用于治疗易损斑块的血管内支架组件的方法。

公开(公告)号：US07258697B1

公开(公告)日：2007-08-21

申请号：US10744115

申请日：2003-12-22

申请人： Daniel L. Cox ,  Christopher Feezor

发明人： Daniel L. Cox ,  Christopher Feezor

IPC分类号： A61F2/06

CPC分类号： A61F2/89 ,  A61F2/848 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2220/005 ,  A61F2230/0013 ,  A61F2230/0054

摘要： A stent for implantation in a body lumen for protecting from rupture a fibrous cap in order to treat vulnerable plaque. One embodiment of the stent achieves staged expansion through stronger and weaker circumferential regions, and includes optional anchors positioned at the circumferential transition between the stronger and weaker regions. During the first stage expansion, the weaker region expands moving the anchors laterally apart. The anchors straddle the fibrous cap and embed into the vessel wall. The second stage expansion of the stent exerts gentler stresses by the weaker region against the fibrous cap while the stronger region exerts greater stresses on the remainder of the vessel wall to open the vessel.

摘要翻译： 用于植入体腔中的支架，用于防止纤维帽破裂以便治疗易损斑块。 支架的一个实施例通过更强和更弱的圆周区域实现分阶段膨胀，并且包括位于较强和较弱区域之间的圆周过渡处的可选锚定件。 在第一阶段的扩张期间，较弱的区域使得锚固体横向分开。 锚固件跨过纤维帽并嵌入血管壁。 支架的第二阶段膨胀对弱纤维帽施加较弱的应力，而较强的区域对容器壁的其余部分施加更大的应力以打开容器。

公开(公告)号：US20050038506A1

公开(公告)日：2005-02-17

申请号：US10295714

申请日：2002-11-15

申请人： William Webler ,  Gregory Hyde ,  Christopher Feezor ,  Daniel Cox

发明人： William Webler ,  Gregory Hyde ,  Christopher Feezor ,  Daniel Cox

IPC分类号： A61F2/02 ,  A61F2/24 ,  A61F2/82

CPC分类号： A61F2/2451 ,  A61F2/91 ,  A61F2002/828 ,  A61F2250/001 ,  Y10T24/39

摘要： A medical device for treating a defective heart valve. The medical device comprises a distal anchoring member for disposing in a blood vessel. A proximal anchoring member for disposing in or at an entrance of the blood vessel. A telescoping assembly coupling at a first end to the distal anchoring member and at a second end to the proximal anchoring member. The telescoping assembly is deployable into the blood vessel. The telescoping assembly reduces a distance between the distal anchoring member and the proximal anchoring member, wherein the telescoping assembly comprises of at least two members capable of sliding into each other giving the telescoping assembly adjustable lengths.

摘要翻译： 一种用于治疗有缺陷心脏瓣膜的医疗装置。 医疗装置包括用于设置在血管中的远侧锚定构件。 用于设置在血管入口处或入口处的近端锚定构件。 伸缩组件在第一端处联接到远侧锚固构件，并且在第二端处联接到近侧锚定构件。 伸缩组件可展开到血管中。 伸缩组件减小了远侧锚固构件和近侧锚固构件之间的距离，其中伸缩组件包括能够相互滑动的至少两个构件，其给予伸缩组件可调长度。

公开(公告)号：US08777990B2

公开(公告)日：2014-07-15

申请号：US12206643

申请日：2008-09-08

申请人： Erik van der Burg ,  Nathaniel Cohen ,  Christopher Feezor ,  Christopher T. Cheng

发明人： Erik van der Burg ,  Nathaniel Cohen ,  Christopher Feezor ,  Christopher T. Cheng

IPC分类号： A61B17/04

CPC分类号： A61B17/0401 ,  A61B2017/0404 ,  A61B2017/0414 ,  A61B2017/0438 ,  A61B2017/045 ,  A61B2017/0451 ,  A61B2017/0453 ,  A61B2017/0464 ,  A61B2050/3015 ,  Y10T24/2164

摘要： A knotless suture anchor provides a method for securing soft tissue to a rigid structure such as bone. The anchor has an inner member that receives suture thread and rotates within an outer tubular member. As the inner member rotates, the suture thread is wrapped onto the inner member thereby increasing contact with the outer tubular member which applies pressure to the wrapped suture thread to retain it in position on the inner member while simultaneously and adjustably tensioning the suture thread. A ratchet prevents undesirable counter-rotation, although the ratchet can be released to permit loosening of the suture thread. Also described is a suture bridge and suture platform for providing further stabilization of a tendon. A method for repairing rotator cuff tears is also described.

摘要翻译： 无缝缝合锚提供了将软组织固定到诸如骨骼的刚性结构的方法。 锚固件具有接收缝合线并在外部管状构件内旋转的内部构件。 当内部构件旋转时，缝合线被包裹在内部构件上，从而增加与外部管状构件的接触，外部管状构件对包裹的缝合线施加压力，以将其保持在内部构件上的适当位置，同时并可调节地张紧缝合线。 棘轮防止不期望的反向旋转，尽管可以释放棘轮以允许缝合线松动。 还描述了一种用于提供肌腱的进一步稳定化的缝合桥和缝合平台。 还描述了修复肩袖撕裂的方法。