公开(公告)号：US20070141051A1

公开(公告)日：2007-06-21

申请号：US11552238

申请日：2006-10-24

申请人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

发明人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：US20070048835A1

公开(公告)日：2007-03-01

申请号：US11552721

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070048833A1

公开(公告)日：2007-03-01

申请号：US11552688

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： C07K14/715 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070048259A1

公开(公告)日：2007-03-01

申请号：US11551356

申请日：2006-10-20

申请人： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

发明人： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC分类号： A61K48/00 ,  A61K38/19

CPC分类号： C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。

公开(公告)号：US20070048223A1

公开(公告)日：2007-03-01

申请号：US11553835

申请日：2006-10-27

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： A61K51/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/46

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20060263850A1

公开(公告)日：2006-11-23

申请号：US11458360

申请日：2006-07-18

申请人： Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

发明人： Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

IPC分类号： C07K14/715 ,  C12P21/06

CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/7155 ,  C07K2319/00

摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

公开(公告)号：US20050214801A1

公开(公告)日：2005-09-29

申请号：US10982555

申请日：2004-11-05

申请人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

发明人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

IPC分类号： C07K14/715 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/09

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20070111266A1

公开(公告)日：2007-05-17

申请号：US11613091

申请日：2006-12-19

申请人： CINDY SPRECHER ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Jane Gross

发明人： CINDY SPRECHER ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Jane Gross

IPC分类号： G01N33/567 ,  C07K16/24 ,  C07K16/28

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K2317/24

摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20070099269A1

公开(公告)日：2007-05-03

申请号：US11549772

申请日：2006-10-16

申请人： JULIA NOVAK ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

发明人： JULIA NOVAK ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06 ,  C12N15/74 ,  C12N1/21

CPC分类号： C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

公开(公告)号：US20070098683A1

公开(公告)日：2007-05-03

申请号：US11551139

申请日：2006-10-19

申请人： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

发明人： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC分类号： A61K38/19 ,  A61K38/20 ,  A61K39/395

CPC分类号： C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.