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    Hybrid compositions for intracellular targeting
    1.
    发明授权
    Hybrid compositions for intracellular targeting 失效
    用于细胞内靶向的杂交组合物

    公开(公告)号：US06482586B1

    公开(公告)日：2002-11-19

    申请号：US08975953

    申请日：1997-11-21

    申请人： Sara Arab ,  Clifford A. Lingwood ,  Aye-Aye Khine

    发明人： Sara Arab ,  Clifford A. Lingwood ,  Aye-Aye Khine

    IPC分类号： C12Q100

    CPC分类号： A61K47/6415 ,  A61K47/54

    摘要： Hybrid compounds comprising a first domain and a second domain are provided. The first domain and the second domain are preferably covalently linked, and the first domain comprises a domain which is capable of specific binding to Gb3; and the second domain comprising a moiety selected from the group consisting of drug moiety, a nucleic acid, a probe, a polypeptide, and a hook, with the proviso that the second domain is not a verotoxin or a fragment thereof. Mehtods of preapring and using the hybrid compounds are also provided.

    摘要翻译： 提供了包含第一结构域和第二结构域的杂化化合物。 第一结构域和第二结构域优选共价连接，并且第一结构域包含能够特异性结合Gb3的结构域; 并且第二结构域包含选自药物部分，核酸，探针，多肽和钩的部分，条件是第二结构域不是脯氨酸或其片段。 还提供了预混合和使用杂化化合物的方法。

    Verotoxin pharmaceutical compositions and medical treatments therewith
    5.
    发明授权
    Verotoxin pharmaceutical compositions and medical treatments therewith 失效
    Verotoxin药物组合物及其治疗

    公开(公告)号：US07560426B2

    公开(公告)日：2009-07-14

    申请号：US11717261

    申请日：2007-03-12

    申请人： Clifford A. Lingwood ,  Ruth Geva, legal representative ,  Leorah Kroyanker, legal representative ,  Richard Hill

    发明人： Hannah Farkas-Himsley

    IPC分类号： C07K14/00

    CPC分类号： A61K51/08 ,  A61K38/164 ,  C07K14/245

    摘要： Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1, have been found to be useful in the treatment of mammalian neoplasia, particularly, ovarian cancer and skin cancer. Surprisingly, although verotoxin 1 has previously been shown to have anti-neoplastic activity in vitro, non-lethal doses of verotoxin 1 have been shown to be therapeutically anti-neoplastic in vivo.

    摘要翻译： 已经发现包含已知的毒素，特别是藜芦毒素1的药物组合物可用于治疗哺乳动物瘤形成，特别是卵巢癌和皮肤癌。 令人惊讶的是，虽然verotoxin 1以前已被证明在体外具有抗肿瘤活性，但非致死剂量的脯氨酸1已被证明在体内具有治疗性的抗肿瘤活性。

    Verocytotoxin receptor assay
    6.
    发明授权
    Verocytotoxin receptor assay 失效
    VEROCYTOTOXIN受体测定

    公开(公告)号：US5164298A

    公开(公告)日：1992-11-17

    申请号：US211289

    申请日：1988-06-24

    申请人： Clifford A. Lingwood ,  Mohammed A. Karmali ,  Magdy T. Basta

    发明人： Clifford A. Lingwood ,  Mohammed A. Karmali ,  Magdy T. Basta

    IPC分类号： G01N33/569 ,  G01N33/92

    CPC分类号： G01N33/92 ,  G01N33/56916 ,  Y10S435/975 ,  Y10S436/829

    摘要： This invention relates to the identification of verocytotoxin receptors of the formula:X--O--Y(R) (I)wherein Y is sphingosine, hydroxylated sphinogosine or saturated sphingosine,wherein X is selected from said group and optionally a polysaccharide linking X to the --O--Y(R) group, andwherein R is H, or a fatty acid and R is linked to the amine moiety of the sphingosine,in combination with an assay component and their use in novel receptor-binding assays for the detection and quantitation of verocytotoxins.

    摘要翻译： 本发明涉及以下分子式的X细胞毒素受体的鉴定：XOY（R）（I）其中Y是鞘氨醇，羟化的鞘氨醇或饱和的鞘氨醇，其中X选自所述基团和任选的连接X与-OY（R ）基团，并且其中R是H或脂肪酸，并且R与鞘氨醇的胺部分连接，并与测定组分结合，以及它们在用于检测和定量细胞毒素的新的受体结合测定中的用途。

    Hybrid compositions for intracellular targeting
    8.
    发明授权
    Hybrid compositions for intracellular targeting 失效
    用于细胞内靶向的杂交组合物

    公开(公告)号：US07335750B2

    公开(公告)日：2008-02-26

    申请号：US10298408

    申请日：2002-11-18

    申请人： Sara Arab ,  Clifford A. Lingwood ,  Aye-Aye Khine

    发明人： Sara Arab ,  Clifford A. Lingwood ,  Aye-Aye Khine

    IPC分类号： C07K14/245 ,  C07H21/02 ,  C07H21/04 ,  A61K38/16 ,  A61K31/7088 ,  C12N5/00 ,  C12N15/87 ,  C12P21/02

    CPC分类号： A61K47/6415 ,  A61K47/54

    摘要： Hybrid compounds comprising a first domain and a second domain are provided. The first domain and the second domain are preferably covalently linked, and the first domain comprises a domain which is capable of specific binding to Gb3; and the second domain comprising a moiety selected from the group consisting of drug moiety, a nucleic acid, a probe, a polypeptide, and a hook, with the proviso that the second domain is not a verotoxin or a fragment thereof. Methods of preparing and using the hybrid compounds are also provided.

    摘要翻译： 提供了包含第一结构域和第二结构域的杂化化合物。 第一结构域和第二结构域优选共价连接，并且第一结构域包含能够特异性结合Gb 3的结构域; 并且第二结构域包含选自药物部分，核酸，探针，多肽和钩的部分，条件是第二结构域不是脯氨酸或其片段。 还提供了制备和使用杂化化合物的方法。

    Verotoxin pharmaceutical compositions and medical treatments therewith
    9.
    发明授权
    Verotoxin pharmaceutical compositions and medical treatments therewith 失效
    Verotoxin药物组合物及其治疗

    公开(公告)号：US06228370B1

    公开(公告)日：2001-05-08

    申请号：US08902247

    申请日：1997-07-29

    申请人： Clifford A. Lingwood ,  Hannah Farkas-Himsley ,  Richard Hill

    发明人： Clifford A. Lingwood ,  Hannah Farkas-Himsley ,  Richard Hill

    IPC分类号： A61K3902

    CPC分类号： A61K38/164 ,  C07K14/245

    摘要： Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1, have been found to be useful in the treatment of mammalian neoplasia, particularly, ovarian cancer and skin cancer. Surprisingly, although verotoxin 1 has previously been shown to have anti-neoplastic activity in vitro, non-lethal doses of verotoxin 1 have been shown to be therapeutically anti-neoplastic in vivo.

    摘要翻译： 已经发现包含已知的毒素，特别是藜芦毒素1的药物组合物可用于治疗哺乳动物瘤形成，特别是卵巢癌和皮肤癌。 令人惊奇的是，虽然verotoxin 1以前已被证明在体外具有抗肿瘤活性，但是非致死剂量的verotoxin1已被证明在体内具有治疗性的抗肿瘤活性。

    Haemophilus adhesin protein
    10.
    发明授权
    Haemophilus adhesin protein 失效
    嗜血杆菌粘附素蛋白

    公开(公告)号：US06218147B1

    公开(公告)日：2001-04-17

    申请号：US09456287

    申请日：1999-12-08

    申请人： Clifford A. Lingwood

    发明人： Clifford A. Lingwood

    IPC分类号： C12N1509

    CPC分类号： C07K14/285 ,  A61K39/102

    摘要： An adhesin protein which binds specifically to phosphatidylethanolamine (PE), gangliotriaosylceramide (Gg3) and gangliotetraosylceramide (Gg4) has been isolated and purified from H. influenzae. Also provided are immunogenic compositions and methods of protecting susceptible mammals from diseases caused by bacterial pathogens having the adhesin as a surface protein.

    摘要翻译： 已经从流感嗜血杆菌中分离和纯化了与磷脂酰乙醇胺（PE），神经节苷脂神经酰胺（Gg3）和神经节四糖基神经酰胺（Gg4）特异性结合的粘附素蛋白。 还提供了免疫原性组合物和保护易感染哺乳动物免受具有粘附素作为表面蛋白质的细菌病原体引起的疾病的方法。