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公开(公告)号：US20250034544A1
公开(公告)日：2025-01-30
申请号：US18714030
申请日：2022-12-01
Applicant: Codexis, Inc.
Inventor： Oscar Alvizo , Scott J. Novick , Nandhitha Subramanian , Thierry Schlama
IPC: C12N9/88
Abstract: The present invention provides engineered threonine aldolase and amino acid decarboxylase polypeptides useful for the production of the chiral tertiary amino alcohols, as well as polynucleotides, compositions, and methods utilizing these engineered polypeptides.
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公开(公告)号：US20250027062A1
公开(公告)日：2025-01-23
申请号：US18903185
申请日：2024-10-01
Applicant: Codexis, Inc.
Inventor： Ericka Bermudez , David Elgart , Nikki D. Kruse , Mathew G. Miller , Vesna Mitchell , Jovana Nazor , Nandhitha Subramanian
Abstract: The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the engineered DNA polymerase polypeptides or compositions thereof for diagnostic and other purposes.
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公开(公告)号：US20240425827A1
公开(公告)日：2024-12-26
申请号：US18822990
申请日：2024-09-03
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Lillian Jasmine Miller , Jesse B. Slaton , Aksiniya Lyubenova Petkova , Nandhitha Subramanian , Joshua Kolev , Anna Fryszkowska , Agustina Rodriguez-Granillo , Grant Murphy
IPC: C12N9/12
Abstract: The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PanK enzymes are also provided. The present invention further provides compositions comprising the PanK enzymes and methods of using the engineered PanK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US12129495B2
公开(公告)日：2024-10-29
申请号：US18046895
申请日：2022-10-14
Applicant: Codexis, Inc.
Inventor： Ericka Bermudez , David Elgart , Nikki D. Kruse , Mathew G. Miller , Vesna Mitchell , Jovana Nazor , Nandhitha Subramanian
CPC classification number: C12N9/1252 , C12N15/63 , C12Y207/07007
Abstract: The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the engineered DNA polymerase polypeptides or compositions thereof for diagnostic and other purposes.
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公开(公告)号：US12129494B2
公开(公告)日：2024-10-29
申请号：US17558454
申请日：2021-12-21
Applicant: Codexis, Inc.
Inventor： Mathew G. Miller , Chinping Chng , Oscar Alvizo , Melissa Ann Mayo , James Nicholas Riggins , Xiang Yi , Jonathan S. Penfield , Gjalt W. Huisman , Jared Davis , Yasushi Saotome
CPC classification number: C12N9/1247 , C12P19/34 , C12Y207/07006 , C12N15/00
Abstract: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
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公开(公告)号：US20240318152A1
公开(公告)日：2024-09-26
申请号：US18516054
申请日：2023-11-21
Applicant: Codexis, Inc.
Inventor： David Entwistle , Jason Fell , Stephan Jenne , Anders Matthew Knight , Simon Ng , Ryan D. Reeves , Zara Maxine Seibel , Jonathan Vroom
IPC: C12N9/02
CPC classification number: C12N9/0071 , C12Y114/14001
Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity on a 1-tert-Butoxycarbonylaminocyclopentanoic acid substrate.
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公开(公告)号：US12071642B2
公开(公告)日：2024-08-27
申请号：US18462237
申请日：2023-09-06
Applicant: Codexis, Inc. , Societe des Produits Nestle S.A.
Inventor： Chinping Chng , Nikki Dellas , Da Duan , Ravi David Garcia , Harvinder Chagger Maniar
CPC classification number: C12N9/2414 , A61K38/47 , A61P1/18 , C12Y302/01001
Abstract: The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH
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公开(公告)号：US12060592B2
公开(公告)日：2024-08-13
申请号：US17089498
申请日：2020-11-04
Applicant: Codexis Inc.
Inventor： Steven J. Collier , Ee Ling Teo , Joly Sukumaran , Robert J. Wilson , Junye Xu
CPC classification number: C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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公开(公告)号：US20240263154A1
公开(公告)日：2024-08-08
申请号：US18628461
申请日：2024-04-05
Applicant: Codexis, Inc.
Inventor： Mathew G. Miller , Vesna Mitchell , Jovana Nazor , Donald S. Baskerville , Nikki Dellas , David Elgart , Jonathan Vroom , Sandy M. Gomes , Nandhitha Subramanian , Ericka Bermudez
IPC: C12N9/12
CPC classification number: C12N9/1252
Abstract: The present invention provides engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The invention also provides methods for use of the compositions comprising the engineered DNA polymerase polypeptides for diagnostic and other purposes.
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10.发明公开
公开(公告)号：US20240228982A9
公开(公告)日：2024-07-11
申请号：US18471524
申请日：2023-09-21
Applicant: Codexis, Inc.
Inventor： Oscar Alvizo , Melissa Ann Mayo , Jeffrey C. Moore
CPC classification number: C12N9/0028 , C12P13/001 , C07K14/195
Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
