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公开(公告)号:US6069238A
公开(公告)日:2000-05-30
申请号:US342073
申请日:1999-06-28
申请人: Stephen Andrew Hitchcock , Chafiq Hamdouchi , Concepcion Sanchez-Martinez , Almudena Rubio Esteban
发明人: Stephen Andrew Hitchcock , Chafiq Hamdouchi , Concepcion Sanchez-Martinez , Almudena Rubio Esteban
CPC分类号: C07H19/01
摘要: An improved and a new synthetic route for the reparation of spirocyclic C-glycoside compounds having the following general structure are described. ##STR1## Novel derivatives of spirocyclic C-glycoside compounds are also disclosed which may be used as intermediates in the synthesis and evaluation of potential pharmaceutically active materials.
摘要翻译: 描述了用于修复具有以下一般结构的螺环C-糖苷化合物的改进和新的合成途径。 还公开了螺环C-糖苷化合物的新型衍生物,其可用作合成和评估潜在的药学活性物质的中间体。
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公开(公告)号:US20100160340A1
公开(公告)日:2010-06-24
申请号:US12637789
申请日:2009-12-15
申请人: David A. COATES , Lawrence Mark GELBERT , John M. KNOBELOCH , Alfonso DE DIOS MAGANA , Ana DE PRADO GONZALEZ , Miriam FILADELFA DEL PRADO CATALINA , Maria Cristina GARCIA PAREDES , Eva Maria MARTIN DE LA NAVA , Maria Dolores MARTIN ORTEGA FINGER , Jose Antonio MARTINEZ PEREZ , Ana Isabel MATEO HERRANZ , Carlos PEREZ MARTINEZ , Concepcion SANCHEZ MARTINEZ
发明人: David A. COATES , Lawrence Mark GELBERT , John M. KNOBELOCH , Alfonso DE DIOS MAGANA , Ana DE PRADO GONZALEZ , Miriam FILADELFA DEL PRADO CATALINA , Maria Cristina GARCIA PAREDES , Eva Maria MARTIN DE LA NAVA , Maria Dolores MARTIN ORTEGA FINGER , Jose Antonio MARTINEZ PEREZ , Ana Isabel MATEO HERRANZ , Carlos PEREZ MARTINEZ , Concepcion SANCHEZ MARTINEZ
IPC分类号: A61K31/497 , C07D403/14 , C07D239/42 , A61K31/506 , A61P35/00
CPC分类号: C07D401/14
摘要: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof which is useful in the treatment of cell proliferative diseases.
摘要翻译: 本发明提供了可用于治疗细胞增殖性疾病的式(I)化合物或其药学上可接受的盐。
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公开(公告)号:US20090318443A1
公开(公告)日:2009-12-24
申请号:US12509886
申请日:2009-07-27
申请人: Rosanne Bonjouklian , Chafiq Hamdouchi Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa Del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
发明人: Rosanne Bonjouklian , Chafiq Hamdouchi Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa Del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
IPC分类号: A61K31/5377 , A61K31/437 , A61P35/00
CPC分类号: C07D471/04
摘要: The present invention provides kinase inhibitors of Formula I.
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公开(公告)号:US07582652B2
公开(公告)日:2009-09-01
申请号:US10597283
申请日:2005-01-25
申请人: Rosanne Bonjouklian , Chafiq Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
发明人: Rosanne Bonjouklian , Chafiq Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
IPC分类号: A01N43/42 , A61K31/44 , C07D513/02 , C07D515/02
CPC分类号: C07D471/04
摘要: The present invention provides kinase inhibitors of Formula I.
摘要翻译: 本发明提供式I的激酶抑制剂。
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公开(公告)号:US20090036445A1
公开(公告)日:2009-02-05
申请号:US10597283
申请日:2005-01-25
申请人: Rosanne Bonjouklian , Chafiq Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
发明人: Rosanne Bonjouklian , Chafiq Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
IPC分类号: A61K31/437 , A61P35/00 , A61K31/5377 , C07D471/04
CPC分类号: C07D471/04
摘要: The present invention provides kinase inhibitors of Formula I.
摘要翻译: 本发明提供式I的激酶抑制剂。
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公开(公告)号:US07320995B2
公开(公告)日:2008-01-22
申请号:US10522227
申请日:2003-07-31
申请人: Rosanne Bonjouklian , Jose Eugenio De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi Hamdouchi , Tiecho Li , Beatriz Lopez De Uralde Garmendia , Michal Vieth , Jeremy Schulenberg York , Robert Dean Dally , Miriam Filadelfa Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Maria Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Alan Shepherd , James Howard Wikel
发明人: Rosanne Bonjouklian , Jose Eugenio De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi Hamdouchi , Tiecho Li , Beatriz Lopez De Uralde Garmendia , Michal Vieth , Jeremy Schulenberg York , Robert Dean Dally , Miriam Filadelfa Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Maria Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Alan Shepherd , James Howard Wikel
IPC分类号: A61K31/4184 , A61K31/428 , C07D277/68 , C07D235/10
CPC分类号: C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D513/04
摘要: The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis
摘要翻译: 本发明提供式I的激酶抑制剂:其中W代表由苯基或噻吩取代的咪唑,恶唑,吡唑,噻唑三唑。 所公开的化合物抑制p-38激酶,并且可用于治疗转移或类风湿性关节炎
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公开(公告)号:US07855211B2
公开(公告)日:2010-12-21
申请号:US12637789
申请日:2009-12-15
申请人: David A Coates , Lawrence Mark Gelbert , John M. Knobeloch , Alfonso De Dios Magana , Ana De Prado Gonzalez , Miriam Filadelfa Del Prado Catalina , Maria Cristina Garcia Paredes , Eva Maria Martin De La Nava , Maria Dolores Martin Ortega Finger , Jose Antonio Martinez Perez , Ana Isabel Mateo Herranz , Carlos Perez Martinez , Concepcion Sanchez Martinez
发明人: David A Coates , Lawrence Mark Gelbert , John M. Knobeloch , Alfonso De Dios Magana , Ana De Prado Gonzalez , Miriam Filadelfa Del Prado Catalina , Maria Cristina Garcia Paredes , Eva Maria Martin De La Nava , Maria Dolores Martin Ortega Finger , Jose Antonio Martinez Perez , Ana Isabel Mateo Herranz , Carlos Perez Martinez , Concepcion Sanchez Martinez
IPC分类号: C07D401/14 , A61K31/517
CPC分类号: C07D401/14
摘要: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof which is useful in the treatment of cell proliferative diseases.
摘要翻译: 本发明提供了可用于治疗细胞增殖性疾病的式(I)化合物或其药学上可接受的盐。
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公开(公告)号:US07109229B2
公开(公告)日:2006-09-19
申请号:US10344245
申请日:2001-09-24
申请人: Thomas Albert Engler , Kelly Wayne Furness , Sushant Malhotra , Stephen Lyle Briggs , Harold Burns Brooks , David K yes Clawson , Concepcion Sanchez-Martinez , Faming Zhang , Guoxin Zhu
发明人: Thomas Albert Engler , Kelly Wayne Furness , Sushant Malhotra , Stephen Lyle Briggs , Harold Burns Brooks , David K yes Clawson , Concepcion Sanchez-Martinez , Faming Zhang , Guoxin Zhu
IPC分类号: A61K31/40 , C07D481/00
CPC分类号: C07D403/14 , C07D487/14
摘要: The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).
摘要翻译: 本文公开的化合物是式(I)的吲哚并唑,其是有效的CDK4抑制剂,并且可用于治疗包括癌症的细胞增殖性疾病。 式(I)。
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公开(公告)号:US20050272791A1
公开(公告)日:2005-12-08
申请号:US10522227
申请日:2003-07-31
申请人: Rosanne Bonjouklian , Jose De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi , Tiecho Li , Beatriz De Uralde Garmendia , Michal Vieth , Jeremy York , Robert Dally , Miriam Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Shepherd , James Wikel
发明人: Rosanne Bonjouklian , Jose De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi , Tiecho Li , Beatriz De Uralde Garmendia , Michal Vieth , Jeremy York , Robert Dally , Miriam Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Shepherd , James Wikel
IPC分类号: A61K31/41 , A61K31/4184 , A61P35/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D513/04 , C07D43/02
CPC分类号: C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D513/04
摘要: The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis.
摘要翻译: 本发明提供式I的激酶抑制剂:其中W代表由苯基或噻吩取代的咪唑,恶唑,吡唑,噻唑三唑。 所公开的化合物抑制p-38激酶,并且可用于治疗转移或类风湿性关节炎。
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