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公开(公告)号：US20110295009A1
公开(公告)日：2011-12-01
申请号：US13056751
申请日：2009-07-16
Applicant: Cosima Dufour-Schroif , Joachim Wink , Martin Gerlitz , Helene Olivan , Michael Kurz
Inventor： Cosima Dufour-Schroif , Joachim Wink , Martin Gerlitz , Helene Olivan , Michael Kurz
IPC: C07D491/107 , C12N1/20 , C12P17/16
CPC classification number: C07D498/10 , C07D491/107
Abstract: The invention relates to streptospirole derivatives of the general formula (I), wherein R1, R2, R3, X1, X2, Y1 and Y2 are as defined herein, a process for the preparation of said compounds by fermenting the microorganism Streptomyces sp. ST 108140 (DSM 19369) and optionally derivatizing the compounds produced by said microorganism, a pharmaceutical composition comprising at least one compound of the formula (I), and the use of a compound of the formula (I) for the preparation of a medicament for the treatment and/or prophylaxis of bacterial infections.
Abstract translation: 本发明涉及通式（I）的链霉菌素衍生物，其中R1，R2，R3，X1，X2，Y1和Y2如本文所定义，通过发酵微生物Streptomyces sp。 ST108404（DSM19369），并任选地衍生由所述微生物产生的化合物，包含至少一种式（I）化合物的药物组合物和式（I）化合物在制备药物中的应用 治疗和/或预防细菌感染。
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公开(公告)号：US08765799B2
公开(公告)日：2014-07-01
申请号：US13056751
申请日：2009-07-16
Applicant: Cosima Dufour-Schroif , Joachim Wink , Martin Gerlitz , Hélène Olivan , Michael Kurz
Inventor： Cosima Dufour-Schroif , Joachim Wink , Martin Gerlitz , Hélène Olivan , Michael Kurz
IPC: A61K31/407 , C07D491/107 , C07D498/10
CPC classification number: C07D498/10 , C07D491/107
Abstract: The invention relates to streptospirole derivatives of the general formula (I), wherein R1, R2, R3, X1, X2, Y1 and Y2 are as defined herein, a process for the preparation of said compounds by fermenting the microorganism Streptomyces sp. ST 108140 (DSM 19369) and optionally derivatizing the compounds produced by said microorganism, a pharmaceutical composition comprising at least one compound of the formula (I), and the use of a compound of the formula (I) for the preparation of a medicament for the treatment and/or prophylaxis of bacterial infections.
Abstract translation: 本发明涉及通式（I）的链霉菌素衍生物，其中R1，R2，R3，X1，X2，Y1和Y2如本文所定义，通过发酵微生物Streptomyces sp。 ST108404（DSM19369），并任选地衍生由所述微生物产生的化合物，包含至少一种式（I）化合物的药物组合物和式（I）化合物在制备药物中的应用 治疗和/或预防细菌感染。
