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38 条记录 (耗时 0.045 秒)

    Deuterated etravirine
    1.
    发明授权
    Deuterated etravirine 有权

    公开(公告)号：US08410124B2

    公开(公告)日：2013-04-02

    申请号：US12288186

    申请日：2008-10-17

    申请人： Craig E. Masse

    发明人： Craig E. Masse

    IPC分类号： A61K31/505 ,  C07D239/02

    CPC分类号： C07D239/48

    摘要： This disclosure relates to novel di-aryl-pyrimidine (DAPY) compounds and pharmaceutically acceptable salts thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a non-nucleoside reverse transcriptase inhibitor (NNRTI).

    SUBSTITUTED OXAZOLIDINONE DERIVATIVES
    5.
    发明申请
    SUBSTITUTED OXAZOLIDINONE DERIVATIVES 有权
    取代的氧杂环丁酮衍生物

    公开(公告)号：US20110281828A1

    公开(公告)日：2011-11-17

    申请号：US13189003

    申请日：2011-07-22

    申请人： Craig E. Masse

    发明人： Craig E. Masse

    IPC分类号： A61K31/5377 ,  A61P7/02 ,  A61P9/10 ,  C12N9/99 ,  A61K31/616

    CPC分类号： C07D413/14

    摘要： This invention relates to novel compounds that are substituted oxazolidinones derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel oxazolidinones compounds that are derivatives of rivaroxaban. The invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and condition that are beneficially treated by administering a selective inhibitor of factor Xa, such as rivaroxaban.

    摘要翻译： 本发明涉及取代的恶唑烷酮衍生物的新化合物及其药学上可接受的盐。 更具体地，本发明涉及作为利伐沙班的衍生物的新的恶唑烷酮化合物。 本发明还提供了包含一种或多种本发明化合物和载体的无热原组合物，以及所公开的化合物和组合物在治疗通过施用选择性因子Xa抑制剂有益治疗的疾病和病症的方法中的用途， 作为利伐沙班。

    TETRAHYDRONAPHTHALENE DERIVATIVES
    6.
    发明申请
    TETRAHYDRONAPHTHALENE DERIVATIVES 有权
    四氢萘衍生物

    公开(公告)号：US20110237635A1

    公开(公告)日：2011-09-29

    申请号：US13038533

    申请日：2011-03-02

    申请人： Roger Tung ,  Craig E. Masse

    发明人： Roger Tung ,  Craig E. Masse

    IPC分类号： A61K31/4184 ,  C07D235/14 ,  A61P9/06 ,  A61P9/12 ,  A61P29/00 ,  A61P9/10 ,  A61P9/04 ,  A61P9/00

    CPC分类号： C07D235/14 ,  A61K31/4184

    摘要： This invention relates to novel tetrahydronaphthalene derivatives, and pharmaceutically acceptable salts thereof according to the following formulae, in one embodiment: as described herein.This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a selective T-type calcium channel blocker.

    摘要翻译： 本发明涉及新的四氢萘衍生物及其药学上可接受的盐，在一个实施方案中：如本文所述。 本发明还提供包含本发明化合物的组合物和这些组合物在治疗通过施用选择性T型钙通道阻断剂有益治疗的疾病和病症的方法中的用途。

    HYDROXYETHYLAMINO SULFONAMIDE DERIVATIVES
    8.
    发明申请
    HYDROXYETHYLAMINO SULFONAMIDE DERIVATIVES 审中-公开
    羟基乙酰胺磺酰胺衍生物

    公开(公告)号：US20100305173A1

    公开(公告)日：2010-12-02

    申请号：US12771551

    申请日：2010-04-30

    申请人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu ,  Craig E. Masse

    发明人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu ,  Craig E. Masse

    IPC分类号： A61K31/428 ,  C07D493/04 ,  A61K31/34 ,  A61K31/427 ,  A61P31/18 ,  A61P33/06 ,  A61K31/36

    CPC分类号： C07D493/04

    摘要： This invention relates to novel hydroxyethylamino sulfonamides, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound with the ability to act as an HIV (human immunodeficiency virus) protease inhibitor.

    摘要翻译： 本发明涉及新的羟乙基氨基磺酰胺，其衍生物，其药学上可接受的盐。 本发明还提供了包含本发明化合物的组合物和这些组合物在治疗通过施用具有作为HIV（人类免疫缺陷病毒）蛋白酶抑制剂的能力的化合物有益治疗的疾病和病症的方法中的用途。

    ANALOGUES OF CILOSTAZOL
    9.
    发明申请
    ANALOGUES OF CILOSTAZOL 有权
    CILOSTAZOL的模拟

    公开(公告)号：US20100249079A1

    公开(公告)日：2010-09-30

    申请号：US12644758

    申请日：2009-12-22

    申请人： Rose A. Persichetti ,  Julie F. Liu ,  Craig E. Masse ,  Scott L. Harbeson

    发明人： Rose A. Persichetti ,  Julie F. Liu ,  Craig E. Masse ,  Scott L. Harbeson

    IPC分类号： A61K31/4709 ,  C07D401/12 ,  A61K31/616 ,  A61K31/4365 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P11/06 ,  A61P3/10

    CPC分类号： C07D215/20 ,  A61K31/10 ,  A61K31/4365 ,  A61K31/4709 ,  A61K31/60 ,  C07D401/12

    摘要： This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of a phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.

    摘要翻译： 本发明涉及作为磷酸二酯酶抑制剂西洛他唑及其药学上可接受的盐的衍生物的新化合物。 本发明还提供了包含一种或多种本发明化合物的无热原组合物，以及所公开的化合物和组合物在治疗通过施用磷酸二酯酶抑制剂如西洛他唑治疗的疾病和病症的方法中的用途。 本发明还涉及所公开的化合物和组合物在涉及西洛他唑的分析研究中作为试剂的用途。