公开(公告)号：US08748111B2

公开(公告)日：2014-06-10

申请号：US13015851

申请日：2011-01-28

申请人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

发明人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

IPC分类号： G01N33/53 ,  C07K2/00 ,  B82Y30/00 ,  G01N33/00 ,  G01N21/55

CPC分类号： G01N21/553 ,  B82Y30/00 ,  C07K2/00 ,  G01N21/554 ,  G01N33/0031 ,  G01N2201/06113 ,  G01N2201/08

摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

摘要翻译： 本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

公开(公告)号：US08088484B2

公开(公告)日：2012-01-03

申请号：US12230622

申请日：2008-09-02

申请人： Kosei Ueno ,  Hiroaki Misawa ,  Dai Ohnishi ,  Takui Sakaguchi ,  Yoichi Mugino

发明人： Kosei Ueno ,  Hiroaki Misawa ,  Dai Ohnishi ,  Takui Sakaguchi ,  Yoichi Mugino

IPC分类号： B32B5/66

CPC分类号： G01J1/02 ,  B22F1/0018 ,  B22F1/0096 ,  B22F2001/0037 ,  B82Y30/00 ,  C22C5/02 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998

摘要： In a metallic structure including a metallic nano-chain with plasmon resonance absorption, a metallic nanoparticle forming the metallic nano-chain is formed in a circular, triangle, or rhomboid shape. The wavelength selectivity can be increased also by forming a closed region by mutually linking all of metallic nanoparticles that are mutually linked with bottlenecks. In a photodetector, a photodetection unit including a current detection probe, a nano-chain unit, and a current detection probe is arranged on a substrate. The nano-chain unit is a metallic structure with plasmon resonance absorption, where metallic nanoparticles are mutually linked with bottlenecks. Each current detection probe has a corner whose tip is formed with a predetermined angle, and this corner is arranged to face the tip of the nano-chain unit, i.e., a corner of the metallic nanoparticle. Photodetection with high wavelength selectivity is performed based on a change in the initial voltage of the current-voltage characteristic.

公开(公告)号：US20090285255A1

公开(公告)日：2009-11-19

申请号：US12225194

申请日：2007-03-20

申请人： Kyosuke Sakai ,  Eiji Miyai ,  Susumu Noda ,  Dai Ohnishi ,  Wataru Kunishi

发明人： Kyosuke Sakai ,  Eiji Miyai ,  Susumu Noda ,  Dai Ohnishi ,  Wataru Kunishi

IPC分类号： H01S5/183

CPC分类号： H01S5/18 ,  B82Y20/00 ,  G11B7/127 ,  H01S5/0425 ,  H01S5/105 ,  H01S5/125 ,  H01S5/2027 ,  H01S5/34313 ,  H01S2301/14 ,  H01S2301/18

摘要： An objective of the present invention is to provide a surface emitting laser capable of selectively generating a laser oscillation in the fundamental mode and thereby emitting a single-wavelength laser light. In a surface emitting laser including an active layer and a two-dimensional photonic crystal provided on one side of the active layer, a reflector 45 or 46 is provided at least at a portion of the circumference of the two-dimensional photonic crystal. The reflector has a reflectance distribution in which the reflectance has a maximum value at a position where the amplitude envelope of the fundamental mode of an internal resonance light created within the two-dimensional photonic crystal. This design strengthens the fundamental mode while suppressing the second mode, thus enabling the laser oscillation in the fundamental mode to be selectively obtained, so that a single-wavelength laser light can be emitted.

摘要翻译： 本发明的目的是提供一种能够选择性地在基模中产生激光振荡并从而发射单波长激光的表面发射激光器。 在包括有源层和设置在有源层的一侧的二维光子晶体的表面发射激光器中，至少在二维光子晶体的圆周的一部分处提供反射器45或46。 反射器具有反射率分布，其中反射率在二维光子晶体内产生的内部共振光的基模的幅度包络的位置处具有最大值。 该设计在抑制第二模式的同时加强基本模式，从而能够选择性地获得基模中的激光振荡，从而可以发射单波长激光。

公开(公告)号：US20090209028A1

公开(公告)日：2009-08-20

申请号：US12346950

申请日：2008-12-31

申请人： Huang Yi Dong ,  Rao Yi ,  Liu Fang ,  Zhang Wei ,  Peng Jiang De ,  Dai Ohnishi ,  Daisuke Niwa ,  Atsushi Tazuke ,  Yoshikatsu Miura

发明人： Huang Yi Dong ,  Rao Yi ,  Liu Fang ,  Zhang Wei ,  Peng Jiang De ,  Dai Ohnishi ,  Daisuke Niwa ,  Atsushi Tazuke ,  Yoshikatsu Miura

IPC分类号： C12M1/34 ,  G01N21/41

CPC分类号： G01N21/553 ,  G01N21/41 ,  G01N21/7703

摘要： There is provided a sensing chip capable of measuring a refractive index by utilizing a long-range surface plasmon polariton, accurately measuring an accumulative refractive index in a wide range, and more easily enabling sealing for measurement. The present invention relates to the sensing chip which has a thin metal film or a strip-like metal grown on an underlayer, and has a dielectric that limits a refractive index and a dielectric buffer layer on an upper surface and a lower surface of the thin metal film or the strip-like metal. The dielectric buffer layer is attached onto the thin metal film or the strip-like metal. The thin metal film or the strip-like metal and the buffer layer are sandwiched between two dielectric layers. A hole is made in a surface of the upper dielectric layer to serve as a measurement groove.

摘要翻译： 提供了一种能够通过利用远程表面等离子体激元测量折射率的感测芯片，精确地测量宽范围内的累积折射率，并且更容易实现测量密封。 本发明涉及一种感测芯片，其具有在底层上生长的薄金属膜或带状金属，并且具有限制薄膜的上表面和下表面上的折射率和介电缓冲层的电介质 金属膜或带状金属。 介电缓冲层附着在薄金属膜或带状金属上。 金属薄膜或带状金属和缓冲层夹在两个电介质层之间。 在上部电介质层的表面形成孔作为测量槽。

公开(公告)号：US20090195783A1

公开(公告)日：2009-08-06

申请号：US12365307

申请日：2009-02-04

申请人： Atsushi Tazuke ,  Daisuke Niwa ,  Yoshikatsu Miura ,  Dai Ohnishi

发明人： Atsushi Tazuke ,  Daisuke Niwa ,  Yoshikatsu Miura ,  Dai Ohnishi

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7776 ,  G01N2021/7783

摘要： A surface plasmon resonance sensor chip includes: a first dielectric layer; a metal layer disposed on the first dielectric layer; and a second dielectric layer covering the metal layer, the chip being provided with an opening that makes a part of a surface on the side of the second dielectric layer of the metal layer be exposed, and allows a measurement sample and the surface on the side of the second dielectric layer to contact each other, wherein an organic molecule film is provided at least one of between the first dielectric layer and the metal layer, and between the metal layer and the second dielectric layer.

摘要翻译： 表面等离子体共振传感器芯片包括：第一介电层; 设置在所述第一电介质层上的金属层; 以及覆盖所述金属层的第二电介质层，所述芯片设置有使金属层的第二电介质层侧的表面的一部分露出的开口，并且允许测量样品和侧面上的表面 的第二电介质层彼此接触，其中在所述第一介电层和所述金属层之间以及所述金属层和所述第二介电层之间的至少一个上设置有机分子膜。

公开(公告)号：US20070158662A1

公开(公告)日：2007-07-12

申请号：US11640837

申请日：2006-12-19

申请人： Dai Ohnishi ,  Susumu Noda

发明人： Dai Ohnishi ,  Susumu Noda

IPC分类号： H01L33/00

CPC分类号： H01L33/24 ,  H01L33/0095 ,  H01L33/20 ,  H01L2933/0083

摘要： A two-dimensional photonic crystal LED composed of a p-type semiconductor cladding layer 12, an active layer 11 of light-emitting material, and an n-type semiconductor cladding layer 13 placed between a pair of electrodes, where air holes 16 penetrating through the layers 12, 11 and 13 and arranged periodically in the layers 12, 11 and 13 are provided. At least a part of the inner wall of the air holes 16 is oxidized 17 in either one or both of the p-type semiconductor cladding layer 12 and the n-type semiconductor cladding layer 13. The holes and electrons injected from the electrodes avoid the oxidized region 17 and enter the active layer 11 apart from the air holes 16, which minimizes the recombination (surface recombination) of the holes and electrons producing heat instead of light.

摘要翻译： 由p型半导体包层12，发光材料的有源层11和放置在一对电极之间的n型半导体包层13构成的二维光子晶体LED，其中气孔16穿透 设置层12,11和13并周期性地布置在层12,11和13中。 空气孔16的内壁的至少一部分在p型半导体包覆层12和n型半导体包层13中的任一个或两个中被氧化17。从电极注入的空穴和电子避免了 氧化区17并且进入与气孔16分开的有源层11，这使空穴和产生热而不是光的电子的复合（表面复合）最小化。

公开(公告)号：US08503498B2

公开(公告)日：2013-08-06

申请号：US13429147

申请日：2012-03-23

申请人： Yoshinori Tanaka ,  Eiji Miyai ,  Dai Ohnishi

发明人： Yoshinori Tanaka ,  Eiji Miyai ,  Dai Ohnishi

IPC分类号： H01S5/00

CPC分类号： H01S5/4031 ,  H01S5/0425 ,  H01S5/209 ,  H01S5/2231 ,  H01S2301/17 ,  H01S2301/176

摘要： A multi-beam semiconductor laser apparatus includes three or more stripe semiconductor laser emission units which are arranged on a substrate, isolation grooves which separate the semiconductor laser emission units from each other, and pad electrodes which are disposed on outer sides of the outermost semiconductor laser emission units. The isolation grooves are formed between the pad electrodes and the semiconductor laser emission units adjacent to the pad electrodes and between adjacent semiconductor laser emission units. A distance between two isolation grooves formed on outer sides of the outermost semiconductor laser light emission units is smaller than a distance between two isolation grooves formed on both sides of inner ones of the semiconductor laser light emission units.

摘要翻译： 多光束半导体激光装置包括：三个以上的条状半导体激光发射单元，其设置在基板上，将半导体激光发射单元彼此分隔开的隔离沟槽和设置在最外侧半导体激光器的外侧的焊盘电极 排放单位。 隔离槽形成在焊盘电极与邻近焊盘电极的相邻半导体激光发射单元之间的半导体激光发射单元之间。 形成在最外侧半导体激光发射单元的外侧的两个隔离槽之间的距离小于形成在半导体激光发射单元的内侧两侧的两个隔离槽之间的距离。

公开(公告)号：US08300672B2

公开(公告)日：2012-10-30

申请号：US13061337

申请日：2009-08-18

申请人： Susumu Noda ,  Seita Iwahashi ,  Yoshitaka Kurosaka ,  Kyosuke Sakai ,  Eiji Miyai ,  Dai Ohnishi ,  Wataru Kunishi

发明人： Susumu Noda ,  Seita Iwahashi ,  Yoshitaka Kurosaka ,  Kyosuke Sakai ,  Eiji Miyai ,  Dai Ohnishi ,  Wataru Kunishi

IPC分类号： H01S5/00

CPC分类号： H01S5/18 ,  H01S5/105 ,  H01S5/187

摘要： A two-dimensional photonic crystal laser light is provided. The two-dimensional photonic crystal laser includes a two-dimensional photonic crystal made of a plate-shaped member provided with a periodic arrangement of identically-shaped modified refractive index areas having a refractive index different from that of the plate-shaped member; and an active layer provided on one side of the two-dimensional photonic crystal. The modified refractive index areas are arranged at lattice points of a lattice with a same period at least in two directions; each modified refractive index area is shaped so that a feedback strength is different with respect to directions of two primitive lattice vectors of the lattice; the two-dimensional photonic crystal has a periodic structure of a supercell, which contains a plurality of lattice points; and the sum of the feedback strengths by all modified refractive index areas in the supercell is identical in each direction of the two primitive lattice vectors.

摘要翻译： 提供二维光子晶体激光。 二维光子晶体激光器包括由板状构件制成的二维光子晶体，该二维光子晶体具有折射率不同于板状构件的相同形状的改性折射率区域的周期性布置; 以及设置在二维光子晶体的一侧上的有源层。 修饰的折射率区域至少在两个方向上布置在具有相同周期的格子的格子点处; 每个修改的折射率区域被成形为使得反馈强度相对于晶格的两个原始晶格矢量的方向是不同的; 二维光子晶体具有包含多个格点的超单元的周期性结构; 并且超级单元中的所有修改的折射率区域的反馈强度的总和在两个原始格子向量的每个方向上是相同的。

公开(公告)号：US20110188526A1

公开(公告)日：2011-08-04

申请号：US13061337

申请日：2009-08-18

申请人： Susumu Noda ,  Seita Iwahashi ,  Yoshitaka Kurosaka ,  Kyosuke Sakai ,  Eiji Miyai ,  Dai Ohnishi ,  Wataru Kunishi

发明人： Susumu Noda ,  Seita Iwahashi ,  Yoshitaka Kurosaka ,  Kyosuke Sakai ,  Eiji Miyai ,  Dai Ohnishi ,  Wataru Kunishi

IPC分类号： H01S3/16

CPC分类号： H01S5/18 ,  H01S5/105 ,  H01S5/187

摘要： A two-dimensional photonic crystal laser light is provided. The two-dimensional photonic crystal laser includes a two-dimensional photonic crystal made of a plate-shaped member provided with a periodic arrangement of identically-shaped modified refractive index areas having a refractive index different from that of the plate-shaped member; and an active layer provided on one side of the two-dimensional photonic crystal. The modified refractive index areas are arranged at lattice points of a lattice with a same period at least in two directions; each modified refractive index area is shaped so that a feedback strength is different with respect to directions of two primitive lattice vectors of the lattice; the two-dimensional photonic crystal has a periodic structure of a supercell, which contains a plurality of lattice points; and the sum of the feedback strengths by all modified refractive index areas in the supercell is identical in each direction of the two primitive lattice vectors.

摘要翻译： 提供二维光子晶体激光。 二维光子晶体激光器包括由板状构件制成的二维光子晶体，该二维光子晶体具有折射率不同于板状构件的相同形状的改性折射率区域的周期性布置; 以及设置在二维光子晶体的一侧上的有源层。 修饰的折射率区域至少在两个方向上布置在具有相同周期的格子的格子点处; 每个修改的折射率区域被成形为使得反馈强度相对于晶格的两个原始晶格矢量的方向是不同的; 二维光子晶体具有包含多个格点的超单元的周期性结构; 并且超级单元中的所有修改的折射率区域的反馈强度的总和在两个原始格子向量的每个方向上是相同的。

公开(公告)号：US20090175304A1

公开(公告)日：2009-07-09

申请号：US12225530

申请日：2007-03-30

申请人： Susumu Noda ,  Yoshitaka Kurosaka ,  Eiji Miyai ,  Dai Ohnishi ,  Wataru Kunishi

发明人： Susumu Noda ,  Yoshitaka Kurosaka ,  Eiji Miyai ,  Dai Ohnishi ,  Wataru Kunishi

IPC分类号： H01S5/00

CPC分类号： H01S5/183 ,  H01S5/105

摘要： A two-dimensional photonic crystal surface emitting laser light source according to the present invention includes a two-dimensional photonic crystal made of a plate-shaped body material provided with a periodic arrangement of identically-shaped holes 242A and an active layer provided on one side of the two-dimensional photonic crystal. The hole 242A is not located on a first half-line 251 extending from the gravity center G1 of the hole in a direction within the plane of the two-dimensional photonic crystal, while the hole 242A is located at least on a portion of a second half-line 252 extending from the gravity center G1 in the direction opposite to the first half-line 251. Injecting electric charges into the active layer generates light, which creates an electric field that encircles the gravity center G1 within the two-dimensional photonic crystal. For a given point on the second half-line 252 at which the hole 242A is located, there is no hole at a point that is symmetrical to the aforementioned point with respect to the gravity center G1, so that there is a difference in the refractive index between the two points. Thus, the electric field vectors at the two points are prevented from canceling each other due to destructive interference, so that the resultant laser light is stronger than conventional examples.

摘要翻译： 根据本发明的二维光子晶体表面发射激光光源包括由板状主体材料制成的二维光子晶体，该二维光子晶体设置有相同形状的孔242A和设置在一侧的活性层的周期性排列 的二维光子晶体。 孔242A不位于从二维光子晶体的平面内的孔的重心G1延伸的第一半线251上，而孔242A至少位于二次光子晶体的一部分上 从重心G1向与第一半线251相反的方向延伸的半线252.向有源层注入电荷产生光，其产生围绕二维光子晶体内的重心G1的电场 。 对于孔242A所在的第二半线252上的给定点，在相对于重心G1与上述点对称的点处没有孔，使得折射率 两点之间的指标。 因此，由于相消干涉，防止两点处的电场矢量彼此抵消，使得所得到的激光比传统例子更强。