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1.
公开(公告)号:US20060189793A1
公开(公告)日:2006-08-24
申请号:US11412373
申请日:2006-04-27
申请人: Frances Yen , Blake Denison , Aymeric Duclert , Lydie Bougueleret , Catherine Clusel , Jean-Baptiste Dumas Milne-Edwards , Bernard Bihain , Barbara Bour , Dana Ebbets-Reed , Luisa Salter-Cid
发明人: Frances Yen , Blake Denison , Aymeric Duclert , Lydie Bougueleret , Catherine Clusel , Jean-Baptiste Dumas Milne-Edwards , Bernard Bihain , Barbara Bour , Dana Ebbets-Reed , Luisa Salter-Cid
IPC分类号: C07K16/30
CPC分类号: C07K16/30 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/47 , C07K14/4747 , C07K2319/02 , C07K2319/21 , C07K2319/32 , C12N15/625
摘要: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptdes. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.
摘要翻译: 本发明提供GSSP-2,GSSP-2 cDNA和GSSP-2多肽的基因组序列。 此外,本发明提供了多核苷酸,其包括衍生自GSSP-2基因的双重标记和来自该基因侧翼的基因组区域。 本发明还提供适用于对含有本发明的一种或多种双重标记物的含有核酸分子的样品进行基因分型的多核苷酸和方法。 此外,本发明提供了检测双标记等位基因和表型之间和/或双重标记单倍型和表型之间的统计学相关性的方法。 本发明还涉及用于杀死肿瘤细胞或抑制肿瘤细胞生长的方法和组合物。 特别地,本发明涉及细胞增殖阻滞/抑制和凋亡/坏死诱导组合物和治疗肿瘤的方法。 本发明涉及新型多肽和编码那些多肽的核酸分子。
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公开(公告)号:US07122644B2
公开(公告)日:2006-10-17
申请号:US10121034
申请日:2002-04-10
申请人: Frances Yen-Potin , Blake Denison , Aymeric Duclert , Lydie Bougueleret , Catherine Clusel , Jean-Baptiste Dumas Milne Edwards , Bernard Bihain , Barbara Bour , Dana Ebbets-Reed , Luisa Salter-Cid
发明人: Frances Yen-Potin , Blake Denison , Aymeric Duclert , Lydie Bougueleret , Catherine Clusel , Jean-Baptiste Dumas Milne Edwards , Bernard Bihain , Barbara Bour , Dana Ebbets-Reed , Luisa Salter-Cid
IPC分类号: C07H21/04
CPC分类号: C07K16/30 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/47 , C07K14/4747 , C07K2319/02 , C07K2319/21 , C07K2319/32 , C12N15/625
摘要: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.
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