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公开(公告)号：US08668934B2
公开(公告)日：2014-03-11
申请号：US12953259
申请日：2010-11-23
Applicant: Reinhard Vehring , Danforth P Miller , David Lechuga-Ballesteros
Inventor： Reinhard Vehring , Danforth P Miller , David Lechuga-Ballesteros
CPC classification number: A61K9/0075 , A61K9/1617 , A61K9/167 , A61K9/1694 , A61K9/5015 , A61K9/5089 , A61K31/00
Abstract: A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent.
Abstract translation: 制备药物制剂的方法包括提供包含第一溶剂，第二溶剂，活性剂和赋形剂的溶液。 第二溶剂的极性比第一溶剂少，赋形剂比活性剂更易溶于水。 从溶液中除去第一和第二溶剂以产生包含活性剂和赋形剂的颗粒。 在一个版本中，赋形剂包含氨基酸和/或磷脂。 由本发明版本制成的药物制剂包含包含至少部分包封活性剂的活性剂和赋形剂的颗粒，其中赋形剂比活性剂更易溶于水。
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公开(公告)号：US20120128728A1
公开(公告)日：2012-05-24
申请号：US12087142
申请日：2006-12-21
Applicant: Richard J. Malcolmson , Theresa D. Sweeney , Danforth P. Miller , Alan R. Kugler , Keith Washco , David Han , Ramakrishna Gadiraju , Farzaneh Nakhjiri
Inventor： Richard J. Malcolmson , Theresa D. Sweeney , Danforth P. Miller , Alan R. Kugler , Keith Washco , David Han , Ramakrishna Gadiraju , Farzaneh Nakhjiri
IPC: A61K9/14 , B32B5/16 , A61P31/10 , A61K31/7048 , C07H17/08
CPC classification number: A61K9/1611 , A61K9/0075 , A61K9/141 , A61K9/1617 , A61K31/7048 , Y10T428/2982
Abstract: The present invention comprises compositions and formulations comprising amphotericin B comprising less than 10% degradants, compositions and formulations comprising amphotericin B with one or more excipients, methods of making amphotericin B compositions and formulations, as well as systems for using amphotericin B compositions and formulations. Also provided are pharmaceutical compositions comprising the formulation, methods of administering the pharmaceutical compositions and methods of treating patients with the pharmaceutical compositions.
Abstract translation: 本发明包括包含两性霉素B的组合物和制剂，其包含少于10％的降解物，包含两性霉素B与一种或多种赋形剂的组合物和制剂，制备两性霉素B组合物和制剂的方法，以及使用两性霉素B组合物和制剂的系统。 还提供了药物组合物，其包含制剂，施用药物组合物的方法和用药物组合物治疗患者的方法。
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公开(公告)号：US20110070309A1
公开(公告)日：2011-03-24
申请号：US12953259
申请日：2010-11-23
Applicant: Reinhard Vehring , Danforth P. Miller , David Lechuga-Ballesteros
Inventor： Reinhard Vehring , Danforth P. Miller , David Lechuga-Ballesteros
IPC: A61K9/14 , A61K47/44 , A61K9/00 , A61K9/12 , A61P31/00 , A61P29/00 , A61P11/00 , A61P9/00 , A61P25/00 , B29B9/16
CPC classification number: A61K9/0075 , A61K9/1617 , A61K9/167 , A61K9/1694 , A61K9/5015 , A61K9/5089 , A61K31/00
Abstract: A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent.
Abstract translation: 制备药物制剂的方法包括提供包含第一溶剂，第二溶剂，活性剂和赋形剂的溶液。 第二溶剂的极性比第一溶剂少，赋形剂比活性剂更易溶于水。 从溶液中除去第一和第二溶剂以产生包含活性剂和赋形剂的颗粒。 在一个版本中，赋形剂包含氨基酸和/或磷脂。 由本发明版本制成的药物制剂包含包含至少部分包封活性剂的活性剂和赋形剂的颗粒，其中赋形剂比活性剂更易溶于水。
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公开(公告)号：US07862834B2
公开(公告)日：2011-01-04
申请号：US10855798
申请日：2004-05-27
Applicant: Reinhard Vehring , Danforth P. Miller , David Lechuga-Ballesteros
Inventor： Reinhard Vehring , Danforth P. Miller , David Lechuga-Ballesteros
CPC classification number: A61K9/0075 , A61K9/1617 , A61K9/167 , A61K9/1694 , A61K9/5015 , A61K9/5089 , A61K31/00
Abstract: A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent.
Abstract translation: 制备药物制剂的方法包括提供包含第一溶剂，第二溶剂，活性剂和赋形剂的溶液。 第二溶剂的极性比第一溶剂少，赋形剂比活性剂更易溶于水。 从溶液中除去第一和第二溶剂以产生包含活性剂和赋形剂的颗粒。 在一个版本中，赋形剂包含氨基酸和/或磷脂。 由本发明版本制成的药物制剂包含包含至少部分包封活性剂的活性剂和赋形剂的颗粒，其中赋形剂比活性剂更易溶于水。
