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公开(公告)号:US20150246881A1
公开(公告)日:2015-09-03
申请号:US14715129
申请日:2015-05-18
申请人: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号: C07D207/38
CPC分类号: C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译: 本发明涉及生产NEP抑制剂或其前药的新方法,特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言,根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成,即根据式(1)的化合物或其盐,其中R 1和R 2各自独立地 另一个是氢或氮保护基,R3是羧基或酯基,优选羧基或烷基酯。
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公开(公告)号:US20070293683A1
公开(公告)日:2007-12-20
申请号:US11845946
申请日:2007-08-28
申请人: Olivier Loiseleur , Daniel Kaufmann , Stephan Abel , Hans Burger , Mark Meisenbach , Beat Schmitz , Gottfried Sedelmeier
发明人: Olivier Loiseleur , Daniel Kaufmann , Stephan Abel , Hans Burger , Mark Meisenbach , Beat Schmitz , Gottfried Sedelmeier
IPC分类号: C07D211/70
CPC分类号: C07D401/04 , C07D295/155 , C07D401/14
摘要: The present invention relates to novel amides and a process for preparing these amides.
摘要翻译: 本发明涉及新颖的酰胺和这些酰胺的制备方法。
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公开(公告)号:US07112673B2
公开(公告)日:2006-09-26
申请号:US10182980
申请日:2001-02-07
IPC分类号: C07D223/22
CPC分类号: C07D223/22
摘要: The invention relates to new processes for the preparation of the pharmaceutical oxcarbazepine, as well as novel intermediates prepared by or used for said processes, and the preparation of said intermediates.
摘要翻译: 本发明涉及制备奥卡西平药物的新方法,以及由所述方法制备或用于所述方法的新型中间体以及所述中间体的制备。
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公开(公告)号:US09403766B2
公开(公告)日:2016-08-02
申请号:US14939513
申请日:2015-11-12
申请人: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号: C07D207/26 , C07D207/38 , C07D207/263 , C07D207/36 , C07D403/06 , C07C271/22
CPC分类号: C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译: 本发明涉及生产NEP抑制剂或其前药的新方法,特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言,根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成,即根据式(1)的化合物或其盐,其中R 1和R 2各自独立地 另一个是氢或氮保护基,R3是羧基或酯基,优选羧基或烷基酯。
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公开(公告)号:US09227934B2
公开(公告)日:2016-01-05
申请号:US14715129
申请日:2015-05-18
申请人: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号: C07D207/38
CPC分类号: C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
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公开(公告)号:US08580974B2
公开(公告)日:2013-11-12
申请号:US12863213
申请日:2009-01-16
申请人: David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人: David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号: C07D207/38 , C07D207/26
CPC分类号: C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要: The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译: 本发明涉及用于产生NEP抑制剂或其前药的新方法,特别是包含γ-氨基-Δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言,根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成,即根据式(1)的化合物或其盐,其中R 1和R 2各自独立地 另一个是氢或氮保护基,R3是羧基或酯基,优选羧基或烷基酯。
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公开(公告)号:US20120126440A1
公开(公告)日:2012-05-24
申请号:US13365349
申请日:2012-02-03
申请人: Michael Ambühl , Corine Gessier-Vial , Christa Hartmann , Daniel Kaufmann , Ernst Küsters , Ulrich Meier , Andreas Meyer , Nabila Sekkat
发明人: Michael Ambühl , Corine Gessier-Vial , Christa Hartmann , Daniel Kaufmann , Ernst Küsters , Ulrich Meier , Andreas Meyer , Nabila Sekkat
IPC分类号: B29B9/12
CPC分类号: A61K33/26 , B01J20/223 , B01J20/2803 , C01G49/0018 , C01G49/02
摘要: The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.
摘要翻译: 本发明涉及一种新的含磷磷酸盐吸附剂及其用途。 用于治疗高磷血症。
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公开(公告)号:US07816359B2
公开(公告)日:2010-10-19
申请号:US11845934
申请日:2007-08-28
申请人: Olivier Loiseleur , Daniel Kaufmann , Stephan Abel , Hans Michael Bürger , Mark Meisenbach , Beat Schmitz , Gottfried Sedelmeier
发明人: Olivier Loiseleur , Daniel Kaufmann , Stephan Abel , Hans Michael Bürger , Mark Meisenbach , Beat Schmitz , Gottfried Sedelmeier
IPC分类号: A61K31/497 , A61K31/505 , A01N43/54
CPC分类号: C07D401/04 , C07D295/155 , C07D401/14
摘要: The present invention relates to novel amides and a process for preparing these amides.
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公开(公告)号:US20100249429A1
公开(公告)日:2010-09-30
申请号:US12815704
申请日:2010-06-15
申请人: Donatienne Denni-Dischert , Hans Hirt , Dan Neville , Gottfried Sedelmeier , Anita Schnyder , Nadine Derrien , Daniel Kaufmann
发明人: Donatienne Denni-Dischert , Hans Hirt , Dan Neville , Gottfried Sedelmeier , Anita Schnyder , Nadine Derrien , Daniel Kaufmann
IPC分类号: C07D257/04
CPC分类号: C07D257/04 , Y02P20/55
摘要: The present invention relates to a process for the manufacture of an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.
摘要翻译: 本发明涉及制备血管紧张素受体阻断剂(ARB,也称为血管紧张素II受体拮抗剂或AT1受体拮抗剂)及其盐的方法,涉及新的中间体和方法步骤。
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公开(公告)号:US20090111995A1
公开(公告)日:2009-04-30
申请号:US12317426
申请日:2008-12-23
申请人: Donatienne Denni-Dischert , Hans Hirt , Dan Neville , Gottfried Sedelmeier , Anita Schnyder , Nadine Derrien , Daniel Kaufmann
发明人: Donatienne Denni-Dischert , Hans Hirt , Dan Neville , Gottfried Sedelmeier , Anita Schnyder , Nadine Derrien , Daniel Kaufmann
IPC分类号: C07D257/04
CPC分类号: C07D257/04 , Y02P20/55
摘要: The present invention relates to a process for the manufacture of an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.
摘要翻译: 本发明涉及制备血管紧张素受体阻断剂(ARB,也称为血管紧张素II受体拮抗剂或AT1受体拮抗剂)及其盐的方法,涉及新的中间体和方法步骤。
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