利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.014 秒)

    Heterocyclic ppar modulators
    3.
    发明申请
    Heterocyclic ppar modulators 审中-公开
    杂环ppar调节剂

    公开(公告)号：US20060241157A1

    公开(公告)日：2006-10-26

    申请号：US10540341

    申请日：2003-12-31

    申请人： Scott Conner ,  Tianwei Ma ,  Nathan Mantlo ,  Daniel Mayhugh ,  Jeffrey Schkeryantz ,  Alan Warshawsky ,  Guoxin Zhu

    发明人： Scott Conner ,  Tianwei Ma ,  Nathan Mantlo ,  Daniel Mayhugh ,  Jeffrey Schkeryantz ,  Alan Warshawsky ,  Guoxin Zhu

    IPC分类号： A61K31/425 ,  A61K31/42 ,  A61K31/415 ,  C07D261/02 ,  C07D231/12

    CPC分类号： C07D231/12 ,  C07D233/20 ,  C07D233/22 ,  C07D233/64 ,  C07D249/06 ,  C07D253/04 ,  C07D261/08

    摘要： The present invention is directed to compounds represented by the following structural formula, Formula I: wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) E is C(R3)(R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsulfonamide; (e) Z1 and Z2 are each independently selected from the group consisting of N, O, and C with the proviso that at least one of Z1 and Z2 is N; (f) Z3 is selected from the group consisting of N, O, and C. (g) R8 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C4 alkylenyl and halo; (h) R9 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkylenyl, halo, aryl-C0-C4 alkyl, heteroaryl, C1-C6 allyl, and OR29.

    摘要翻译： 本发明涉及由以下结构式（I）表示的化合物：其中：（a）X选自单键，O，S，S（O）2和N; （b）U是脂族连接体; （c）Y选自O，C，S，NH和单键; （d）E是C（R3）（R4）A或A，其中（i）A选自羧基，四唑，C 1 -C 6烷基腈，甲酰胺，磺酰胺和酰基磺酰胺; （e）Z1和Z2各自独立地选自N，O和C，条件是Z1和Z2中的至少一个是N; （f）Z 3选自N，O和C.（g）R 8选自氢，C 1 -C 6烷基，C 1 -C 4亚烷基和卤素; （h）R 9选自氢，C 1 -C 4烷基，C 1 -C 4亚烷基，卤素，芳基-C 0 -C 4烷基，杂芳基，C 1 -C 6烯丙基和OR 29。