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公开(公告)号:US07598391B2
公开(公告)日:2009-10-06
申请号:US11453330
申请日:2006-06-14
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
IPC分类号: C07D277/26
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US08263634B2
公开(公告)日:2012-09-11
申请号:US12942297
申请日:2010-11-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswarak Santhosh
IPC分类号: A61K31/426 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/12
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US07851636B2
公开(公告)日:2010-12-14
申请号:US12757217
申请日:2010-04-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
IPC分类号: C07D277/20 , A61K31/426
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US20100036150A1
公开(公告)日:2010-02-11
申请号:US12446775
申请日:2007-10-24
申请人: Dharma Rao Polisetti , Daniel P. Christen , Mustafa Guzel , Thomas Scott Yokum , Muralidhar Bondlela
发明人: Dharma Rao Polisetti , Daniel P. Christen , Mustafa Guzel , Thomas Scott Yokum , Muralidhar Bondlela
CPC分类号: C07C69/734 , C12P7/42 , C12P41/004
摘要: The invention relates to compounds, compositions, methods of using and processes for producing optically active α-hydroxy derivatives using a combination of a chemical and biochemical methods. The process comprises reacting an ester compound with a racemic compound in the presence of an enzyme to obtain compounds (compositions and methods). The compounds produced may be useful for starting materials for physiologically active materials, functional materials and the like.
摘要翻译: 本发明涉及使用化学和生物化学方法的组合的化合物,组合物,使用方法和制备光学活性α-羟基衍生物的方法。 该方法包括在酶的存在下使酯化合物与外消旋化合物反应以获得化合物(组合物和方法)。 制备的化合物可用于生理活性材料,功能材料等的起始材料。
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公开(公告)号:US20090216013A1
公开(公告)日:2009-08-27
申请号:US12188402
申请日:2008-08-08
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswara Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswara Santhosh
IPC分类号: C07D223/02 , C07D277/20 , C07D285/12 , C07D277/62 , C07D285/08 , C07D213/02 , C07D241/10 , C07D401/02 , C07D295/00 , C07D239/24 , C07D417/02 , C07D413/14
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US08211925B2
公开(公告)日:2012-07-03
申请号:US12298840
申请日:2007-04-27
申请人: Anthony Murray , Jesper Lau , Lone Jeppsen , Per Vedsø , Dharma Rao Polisetti , Bapu Reddy Gaddam , Daniel P. Christen , Kalpathy Chidambareswaran Santhosh , Jeremy T. Cooper , Robert Carl Andrews
发明人: Anthony Murray , Jesper Lau , Lone Jeppsen , Per Vedsø , Dharma Rao Polisetti , Bapu Reddy Gaddam , Daniel P. Christen , Kalpathy Chidambareswaran Santhosh , Jeremy T. Cooper , Robert Carl Andrews
IPC分类号: A61K31/426 , C07D277/44
CPC分类号: C07D277/46 , Y02P20/582
摘要: The present invention relates to N-heteroaryl-benzamides, pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful in diseases or medical conditions mediated by glucokinase.
摘要翻译: 本发明涉及N-杂芳基 - 苯甲酰胺,包含它们的药物组合物及其使用方法。 N-杂芳基 - 苯甲酰胺可用于由葡糖激酶介导的疾病或医学病症。
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公开(公告)号:US07872139B2
公开(公告)日:2011-01-18
申请号:US12188402
申请日:2008-08-08
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaram Santhosh
IPC分类号: C07D417/06
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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公开(公告)号:US20100331379A1
公开(公告)日:2010-12-30
申请号:US12298840
申请日:2007-04-27
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Dharma Rao Polisetti , Bapu Gaddam , Daniel P. Christen , Kalpathy Santhosh , Jeremy T. Cooper , Robert Carl Andrews
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedso , Dharma Rao Polisetti , Bapu Gaddam , Daniel P. Christen , Kalpathy Santhosh , Jeremy T. Cooper , Robert Carl Andrews
IPC分类号: A61K31/426 , C07D277/44
CPC分类号: C07D277/46 , Y02P20/582
摘要: The present invention relates to N-heteroaryl-benzamides, pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful in diseases or medical conditions mediated by glucokinase.
摘要翻译: 本发明涉及N-杂芳基 - 苯甲酰胺,包含它们的药物组合物及其使用方法。 N-杂芳基 - 苯甲酰胺可用于由葡糖激酶介导的疾病或医学病症。
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公开(公告)号:US20100204288A1
公开(公告)日:2010-08-12
申请号:US12757217
申请日:2010-04-09
申请人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
发明人: Anthony Murray , Jesper Lau , Lone Jeppesen , Per Vedsø , Michael Ankersen , Jane Marie Lundbeck , Marit Kristiansen , Maria Carmen Valcarce-Lopez , Dharma Rao Polisetti , Govindan Subramanian , Robert Carl Andrews , Daniel P. Christen , Jeremy T. Cooper , Kalpathy Chidambareswaran Santhosh
IPC分类号: A61K31/426 , C07D277/54 , A61P3/10 , A61P3/06 , A61P9/12
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要: This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译: 本发明涉及作为葡萄糖激酶活化剂的式(I)化合物,因此可用于治疗,治疗,控制或辅助治疗疾病,其中增加葡糖激酶活性是有益的。
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10.
公开(公告)号:US08383644B2
公开(公告)日:2013-02-26
申请号:US12825631
申请日:2010-06-29
申请人: Adnan M. M. Mjalli , Christopher Behme , Daniel P. Christen , Devi Reddy Gohimukkula , Dharma Rao Polisetti , James Quada , Jennifer L. R. Freeman , Kalpathy Santhosh , Muralidhar Bondlela , Mustafa Guzel , Ravindra Reddy Yarragunta , Robert Carl Andrews , Stephen Thomas Davis , Thomas Scott Yokum
发明人: Adnan M. M. Mjalli , Christopher Behme , Daniel P. Christen , Devi Reddy Gohimukkula , Dharma Rao Polisetti , James Quada , Jennifer L. R. Freeman , Kalpathy Santhosh , Muralidhar Bondlela , Mustafa Guzel , Ravindra Reddy Yarragunta , Robert Carl Andrews , Stephen Thomas Davis , Thomas Scott Yokum
IPC分类号: C07D491/056 , A61K31/436
CPC分类号: C07D491/056 , C07D319/20 , C07D491/06
摘要: The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.
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