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公开(公告)号：US09029395B2
公开(公告)日：2015-05-12
申请号：US14111580
申请日：2012-04-19
Applicant: Dominique Amans , Emmanuel Hubert Demont , Darren Jason Mitchell , Robert J. Watson
Inventor： Dominique Amans , Emmanuel Hubert Demont , Darren Jason Mitchell , Robert J. Watson
IPC: C07D215/44 , C07D215/42 , C07D401/12
CPC classification number: C07D215/44 , C07D215/42 , C07D401/12
Abstract: Tetrahydroquinoline derivatives, pharmaceutical compositions containing such compounds and to their use in therapy.
Abstract translation: 四氢喹啉衍生物，含有这些化合物的药物组合物及其在治疗中的应用。
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公开(公告)号：US20140031336A1
公开(公告)日：2014-01-30
申请号：US14111625
申请日：2012-04-19
Applicant: Dominique Amans , Emmanuel Hubert Demont , Darren Jason Mitchell , Jonathan Thomas Seal
IPC: C07D215/42 , C07D401/14 , C07D401/12
CPC classification number: C07D215/42 , C07D215/44 , C07D401/04 , C07D401/12 , C07D401/14
Abstract: Tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and their use in therapy.
Abstract translation: 四氢喹啉化合物，含有这些化合物的药物组合物及其在治疗中的用途。
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公开(公告)号：US20090192160A1
公开(公告)日：2009-07-30
申请号：US12417176
申请日：2009-04-02
Applicant: Darren Jason MITCHELL , Jonathan Thomas Seal , Mervyn Thompson , Susan Marie Westway , Samantha Louisa Brown
Inventor： Darren Jason MITCHELL , Jonathan Thomas Seal , Mervyn Thompson , Susan Marie Westway , Samantha Louisa Brown
IPC: A61K31/496 , C07D401/12 , C07D413/14 , A61K31/5377 , A61P1/00
CPC classification number: C07D295/135 , C07D213/78 , C07D239/28
Abstract: The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.
Abstract translation: 本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在治疗通过GPR38受体介导的病症或病症中的用途。
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公开(公告)号：US08993554B2
公开(公告)日：2015-03-31
申请号：US14111625
申请日：2012-04-19
Applicant: Dominique Amans , Emmanuel Hubert Demont , Darren Jason Mitchell , Jonathan Thomas Seal
IPC: C07D215/42 , C07D401/12 , C07D401/14 , C07D215/44 , C07D401/04
CPC classification number: C07D215/42 , C07D215/44 , C07D401/04 , C07D401/12 , C07D401/14
Abstract: Tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and their use in therapy.
Abstract translation: 四氢喹啉化合物，含有这些化合物的药物组合物及其在治疗中的用途。
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5.发明申请PIPERAZINYL-SULFONAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES 失效用于治疗GPR38受体介导的疾病的哌嗪 - 磺酰胺衍生物公开(公告)号：US20100256364A1
公开(公告)日：2010-10-07
申请号：US12744367
申请日：2008-11-26
Applicant: Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
Inventor： Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
IPC: C07D413/14 , C07D401/12 , C07D401/14
CPC classification number: C07D401/12 , C07D241/02
Abstract: Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
Abstract translation: 公开了胃动素激动剂，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。
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Patent Agency Ranking
公开(公告)号：US07538121B2
公开(公告)日：2009-05-26
申请号：US10503648
申请日：2003-02-13
Applicant: Gregor James MacDonald , Darren Jason Mitchell , Harshad Kantilal Rami , Mervyn Thompson , Susan Marie Westaway
Inventor： Gregor James MacDonald , Darren Jason Mitchell , Harshad Kantilal Rami , Mervyn Thompson , Susan Marie Westaway
IPC: C07D403/02 , A61K31/47
CPC classification number: C07D401/12 , C07D215/38 , C07D409/12 , C07D409/14
Abstract: Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, P, X, Y, q, r ans s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds in medicine.
Abstract translation: 某些式（I）化合物或其药学上可接受的盐或溶剂合物，其中R 1，R 2，R 3，P，X，Y，q，r s s如本说明书中所定义，制备此类化合物的方法， 包含这些化合物的药物组合物和这些化合物在医药中的用途。
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公开(公告)号：US20080306083A1
公开(公告)日：2008-12-11
申请号：US12096104
申请日：2006-12-01
Applicant: Gregor James MacDonald , Darren Jason Mitchell , Mervyn Thompson , Susan Marie Westaway
IPC: A61K31/496 , C07D401/14
CPC classification number: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14
Abstract: The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
Abstract translation: 本发明涉及新型联芳基衍生物，例如具有作为GPR38受体激动剂的活性的式（I）化合物以及这些化合物或其药物组合物在治疗胃肠道疾病中的用途。
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公开(公告)号：US08853218B2
公开(公告)日：2014-10-07
申请号：US12417176
申请日：2009-04-02
Applicant: Darren Jason Mitchell , Jonathan Thomas Seal , Mervyn Thompson , Susan Marie Westaway , Samantha Louisa Brown
Inventor： Darren Jason Mitchell , Jonathan Thomas Seal , Mervyn Thompson , Susan Marie Westaway , Samantha Louisa Brown
IPC: A01N43/54 , C07D401/04 , C07D213/78 , C07D295/135 , C07D239/28
CPC classification number: C07D295/135 , C07D213/78 , C07D239/28
Abstract: The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.
Abstract translation: 本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在治疗通过GPR38受体介导的病症或病症中的用途。
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9.发明授权Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases 失效可用于治疗GPR38受体介导的疾病的哌嗪基 - 磺酰胺衍生物公开(公告)号：US07964597B2
公开(公告)日：2011-06-21
申请号：US12744367
申请日：2008-11-26
Applicant: Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
Inventor： Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
IPC: A61K31/5377 , A61K31/496 , C07D295/12 , C07D401/12 , C07D401/14 , C07D413/14
CPC classification number: C07D401/12 , C07D241/02
Abstract: Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
Abstract translation: 公开了胃动素激动剂，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。
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公开(公告)号：US07964602B2
公开(公告)日：2011-06-21
申请号：US12096104
申请日：2006-12-01
Applicant: Gregor James MacDonald , Darren Jason Mitchell , Mervyn Thompson , Susan Marie Westaway
IPC: A61K31/496 , C07D401/14 , C07D409/14 , C07D417/14
CPC classification number: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14
Abstract: The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
Abstract translation: 本发明涉及新型联芳基衍生物，例如具有作为GPR38受体激动剂的活性的式（I）化合物以及这些化合物或其药物组合物在治疗胃肠道疾病中的用途。
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