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公开(公告)号：US08119978B2
公开(公告)日：2012-02-21
申请号：US12373159
申请日：2007-07-10
Applicant: Mohammad K. Islam , Bernhard D. Norrlinger , Duncan M. Galbraith , David A. Jaffray , Robert K. Heaton , Jason Smale
Inventor： Mohammad K. Islam , Bernhard D. Norrlinger , Duncan M. Galbraith , David A. Jaffray , Robert K. Heaton , Jason Smale
IPC: G01D18/00
CPC classification number: H01J47/02 , A61N5/1042 , A61N5/1048 , A61N5/1067 , G01T1/185 , G01T1/2935
Abstract: Various embodiments are described herein for an area integrated fluence monitoring sensor that can be used to measure a radiation dose. The sensor comprises at least one Gradient Ion Chamber (GIC) comprising an ion chamber having a volume gradient across a length or width thereof, a gas or liquid located within the ion chamber and an electrode to detect ions generated within the gas or liquid when the at least one GIC is subjected to an ionizing radiation beam. Various embodiments are also described herein for an Integral Quality Monitoring system and associated method that can be used to measure and monitor the quality of radiation doses provided by a radiation treatment system.
Abstract translation: 本文描述了可用于测量辐射剂量的区域集成注量监测传感器的各种实施例。 传感器包括至少一个梯度离子室（GIC），其包括具有其长度或宽度的体积梯度的离子室，位于离子室内的气体或液体，以及用于检测气体或液体中产生的离子的电极 至少一个GIC经受电离辐射束。 本文还描述了可用于测量和监测由辐射治疗系统提供的辐射剂量的质量的整体质量监测系统和相关方法的各种实施例。
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公开(公告)号：US07729473B2
公开(公告)日：2010-06-01
申请号：US12181492
申请日：2008-07-29
Applicant: David A. Jaffray , Kevin John Brown , Gregory Bootsma , Mark Ruschin , Per Carlsson
Inventor： David A. Jaffray , Kevin John Brown , Gregory Bootsma , Mark Ruschin , Per Carlsson
CPC classification number: A61N5/1084 , A61N5/1065 , A61N2005/1059 , A61N2005/1061 , A61N2005/1063 , A61N2005/1097
Abstract: A highly compact, high-performance volumetric imaging system is proposed, that is integrated with a multi-source Cobalt-60 gamma irradiator for high throughput, high accuracy and minimally invasive fractioned treatments of intracranial, orbital and head-and-neck targets.
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公开(公告)号：US20100027744A1
公开(公告)日：2010-02-04
申请号：US12181492
申请日：2008-07-29
Applicant: Kevin John Brown , Gregory Bootsma , Mark Ruschin , David A. Jaffray , Per Carlsson
Inventor： Kevin John Brown , Gregory Bootsma , Mark Ruschin , David A. Jaffray , Per Carlsson
IPC: A61N5/10
CPC classification number: A61N5/1084 , A61N5/1065 , A61N2005/1059 , A61N2005/1061 , A61N2005/1063 , A61N2005/1097
Abstract: A highly compact, high-performance volumetric imaging system is proposed, that is integrated with a multi-source Cobalt-60 gamma irradiator for high throughput, high accuracy and minimally invasive fractioned treatments of intracranial, orbital and head-and-neck targets.
Abstract translation: 提出了一种高度紧凑，高性能的体积成像系统，其与多源Cobalt-60伽马辐射器集成，用于高通量，高精度和微创分级治疗颅内，眼眶和头颈部靶标。
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公开(公告)号：US07471765B2
公开(公告)日：2008-12-30
申请号：US11023037
申请日：2004-12-27
Applicant: David A. Jaffray , John W. Wong , Jeffrey H. Siewerdesen
Inventor： David A. Jaffray , John W. Wong , Jeffrey H. Siewerdesen
IPC: A61N5/10
CPC classification number: A61B6/032 , A61B6/027 , A61B6/06 , A61B6/4085 , A61B6/4405 , A61B6/4458 , A61B6/466 , A61B6/482 , A61B6/508 , A61B6/583 , A61N5/1038 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1061
Abstract: A radiation therapy system that includes a radiation source that moves about a path and directs a beam of radiation towards an object and a cone-beam computer tomography system. The cone-beam computer tomography system includes an x-ray source that emits an x-ray beam in a cone-beam form towards an object to be imaged and an amorphous silicon flat-panel imager receiving x-rays after they pass through the object, the imager providing an image of the object. A computer is connected to the radiation source and the cone beam computerized tomography system, wherein the computer receives the image of the object and based on the image sends a signal to the radiation source that controls the path of the radiation source.
Abstract translation: 一种放射治疗系统，其包括围绕路径移动并将辐射束引向物体的辐射源和锥束计算机断层摄影系统。 锥束计算机断层摄影系统包括：x射线源，其以锥形束朝向待成像的物体发射X射线束;以及非晶硅平板成像器，在它们通过物体之后接收x射线 ，成像器提供对象的图像。 计算机连接到辐射源和锥束计算机断层摄影系统，其中计算机接收对象的图像并且基于图像将信号发送到控制辐射源的路径的辐射源。
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5.发明申请IMAGEABLE ACTIVATABLE AGENT FOR RADIATION THERAPY AND METHOD AND SYSTEM FOR RADIATION THERAPY 审中-公开用于放射治疗的可成像的激活剂和用于放射治疗的方法和系统公开(公告)号：US20130261371A1
公开(公告)日：2013-10-03
申请号：US13696005
申请日：2011-05-03
Applicant: David A. Jaffray , Christine Allen , Devika Chithrani , Jinzi Zheng , Justin Grant
Inventor： David A. Jaffray , Christine Allen , Devika Chithrani , Jinzi Zheng , Justin Grant
IPC: A61N5/00
CPC classification number: A61N5/00 , A61K9/0009 , A61K9/127 , A61K41/0028 , A61K41/0038 , A61K49/1812 , A61M31/005 , A61N5/10 , A61N2005/1094 , A61N2005/1098
Abstract: Imageable disruptable capsules containing a sensitizing agent or a protecting agent are used to enhance radiation therapy. Said capsules may be imaged by a non-invasive imaging modality, allowing for the determination of the precise timing to disrupt the capsule and release the sensitizing agent or protecting agent using an external energy source. This controlled and timed release of the sensitizing agent or protecting agent provides for enhanced radiation therapy by optimizing the delivery of the sensitizing agent or protecting agent to the target tissues. Systems comprising non-invasive imaging modalities, external energy sources and radiation energy sources are also taught for use with these imageable disruptable capsules.
Abstract translation: 使用含有敏化剂或保护剂的可成像的可破坏胶囊来增强放射治疗。 可以通过非侵入性成像模式对所述胶囊进行成像，从而允许确定干扰胶囊的精确时间并使用外部能量源释放敏化剂或保护剂。 敏感剂或保护剂的这种受控和定时的释放通过优化敏化剂或保护剂向目标组织的递送来提供增强的放射治疗。 还教导了包括非侵入性成像模式，外部能量源和辐射能源的系统与这些可成像的可破坏胶囊一起使用。
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Patent Agency Ranking
公开(公告)号：US08135111B2
公开(公告)日：2012-03-13
申请号：US12917079
申请日：2010-11-01
Applicant: David A. Jaffray , John W. Wong , Jeffrey H. Siewerdesen
Inventor： David A. Jaffray , John W. Wong , Jeffrey H. Siewerdesen
CPC classification number: A61B6/032 , A61B6/027 , A61B6/06 , A61B6/4085 , A61B6/4405 , A61B6/4458 , A61B6/466 , A61B6/482 , A61B6/508 , A61B6/583 , A61N5/1038 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1061
Abstract: A radiation therapy system that includes a radiation source that moves about a path and directs a beam of radiation towards an object and a cone-beam computer tomography system. The cone-beam computer tomography system includes an x-ray source that emits an x-ray beam in a cone-beam form towards an object to be imaged and an amorphous silicon flat-panel imager receiving x-rays after they pass through the object, the imager providing an image of the object. A computer is connected to the radiation source and the cone beam computerized tomography system, wherein the computer receives the image of the object and based on the image sends a signal to the radiation source that controls the path of the radiation source.
Abstract translation: 一种放射治疗系统，其包括围绕路径移动并将辐射束引向物体的辐射源和锥束计算机断层摄影系统。 锥束计算机断层摄影系统包括：x射线源，其以锥形束朝向待成像的物体发射X射线束;以及非晶硅平板成像器，在它们通过物体之后接收x射线 ，成像器提供对象的图像。 计算机连接到辐射源和锥束计算机断层摄影系统，其中计算机接收对象的图像并且基于图像将信号发送到控制辐射源的路径的辐射源。
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7.发明申请RETROSPECTIVE SORTING OF 4D CT INTO BREATHING PHASES BASED ON GEOMETRIC ANALYSIS OF IMAGING FIDUCIALS 有权基于图像成像几何分析的4D CT进入呼吸相的重新分类公开(公告)号：US20090116719A1
公开(公告)日：2009-05-07
申请号：US12300340
申请日：2007-05-01
Applicant: David A. Jaffray , Michael R. Kaus , Jeremy D. P. Hoisak , Thomas G. Purdie
Inventor： David A. Jaffray , Michael R. Kaus , Jeremy D. P. Hoisak , Thomas G. Purdie
IPC: G06K9/00
CPC classification number: A61B90/39 , A61B5/7289 , A61B6/12 , A61B6/5217 , A61B2090/376 , A61B2090/392 , G06T7/73 , G06T11/005 , G06T2207/10076 , G06T2207/30004 , G06T2211/412
Abstract: A respiratory marker (40, 140, 240, 340, 440) includes an elongated detectable portion (42, 342, 442) that is operatively coupled with respiration of an imaging subject such that the elongated detectable portion moves with the respiration. The elongated detectable portion is arranged to intersect images acquired by an imaging scanner (10) at different times and at different positions along a scanner axis (20), and is detectable as a marker feature in the images. A marker position finder (52, 54) is configured to determine positions of the marker features in the images.
Abstract translation: 呼吸标记物（40,140,240,340,440）包括细长的可检测部分（42,342,442），其与成像对象的呼吸可操作地耦合，使得细长的可检测部分随呼吸移动。 细长的可检测部分布置成与成像扫描器（10）在不同时间和沿着扫描器轴线（20）的不同位置相交的图像相交，并且作为图像中的标记特征可检测。 标记位置查找器（52,54）被配置为确定图像中的标记特征的位置。
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8.发明授权Method and apparatus for delivering radiation therapy during suspended ventilation 失效在悬吊通气期间传送放射治疗的方法和装置公开(公告)号：US07393329B1
公开(公告)日：2008-07-01
申请号：US09424431
申请日：1998-05-22
Applicant: John W. Wong , David A. Jaffray , Michael B. Sharpe , John R. Musselwhite
Inventor： John W. Wong , David A. Jaffray , Michael B. Sharpe , John R. Musselwhite
IPC: A61B5/08
CPC classification number: A61N5/1048 , A61M16/024 , A61M16/106 , A61M16/22 , A61M2016/0036 , A61N5/1064 , Y10S128/916
Abstract: Methods and apparatus for delivering radiation therapy to patients during suspended ventilation are provided. The apparatus includes a ventilator assembly having first and second selectively operable valves that independently control inhalation and exhalation of the patient. Both valves are shut to suspend patient ventilation for a period of time. In the methods of the present invention, radiation therapy is administered during this period of suspended patient ventilation.
Abstract translation: 提供了在悬浮通气期间向患者输送辐射治疗的方法和装置。 该装置包括具有独立地控制患者的吸入和呼气的第一和第二可选择性操作的阀的通气机组件。 关闭两个阀门以暂停患者通气一段时间。 在本发明的方法中，在暂停患者通气期间施用放射治疗。
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公开(公告)号：US07147373B2
公开(公告)日：2006-12-12
申请号：US10915015
申请日：2004-08-09
Applicant: Young-bin Cho , Douglas J. Moseley , Jeffrey H. Siewerdsen , David A. Jaffray
Inventor： Young-bin Cho , Douglas J. Moseley , Jeffrey H. Siewerdsen , David A. Jaffray
CPC classification number: A61B6/583 , A61B6/027 , A61B6/4071 , A61B6/547 , A61B6/584 , A61B6/585 , A61B6/587 , A61N5/1049 , A61N2005/1061
Abstract: A system for obtaining coordinate data of a source and detector instrument are described. The system includes a marker assembly having a plurality of markers with a particular geometry, and an energy source for targeting the plurality of markers with energy packets. The system further includes a detector for detecting energy packets after the plurality of markers have interacted therewith, and an image device for forming image data of the plurality of markers from the energy packets detected by the detector. A calibration module for utilizes the particular geometry of the plurality of markers and the image data to non-iteratively determine coordinate data.
Abstract translation: 描述用于获取源和检测器仪器的坐标数据的系统。 该系统包括具有特定几何形状的多个标记的标记组件，以及用能量包对准多个标记的能量源。 该系统还包括一个检测器，用于在多个标记与之相互作用之后检测能量包;以及图像装置，用于根据由检测器检测到的能量包形成多个标记的图像数据。 用于利用多个标记的特定几何和图像数据的校准模块来非迭代地确定坐标数据。
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10.发明申请OPTIMIZED APERTURE SELECTION IMAGING COMPUTED TOMOGRAPHY SYSTEM AND METHOD 有权优化的APERTURE选择成像计算机图像系统和方法公开(公告)号：US20120002781A1
公开(公告)日：2012-01-05
申请号：US13209731
申请日：2011-08-15
Applicant: Sean A. Graham , David A. Jaffray , Jeffrey H. Siewerdsen
Inventor： Sean A. Graham , David A. Jaffray , Jeffrey H. Siewerdsen
IPC: A61B6/03
Abstract: A method and imaging system for operating imaging computed tomography using a radiation source and a plurality of detectors to generate an image of an object. The method includes: defining a desired image characteristics; and performing calculations to determine the pattern of fluence to be applied by the radiation source, to generate said desired image quality or characteristics. Then, the radiation source is modulated, to generate the intended pattern of fluence between the beam source and the object to be imaged. The desired image characteristics can comprise at least one of desired levels of contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR), and may provide at least one of: desired image quality in at least one defined region of interest; and at least one desired distribution of said image quality.
Abstract translation: 一种用于使用辐射源和多个检测器操作成像计算机断层摄影器以生成对象的图像的方法和成像系统。 该方法包括：定义所需的图像特征; 并执行计算以确定由辐射源施加的注量的模式，以产生所述期望的图像质量或特性。 然后，对辐射源进行调制，以产生射束源和待成像物体之间的注量模式。 期望的图像特征可以包括所需等级的对比噪声比（CNR）和信噪比（SNR）中的至少一个，并且可以提供以下至少一个：至少一个限定区域中的期望图像质量 出于兴趣; 以及所述图像质量的至少一个期望分布。
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