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公开(公告)号：US20130065306A1
公开(公告)日：2013-03-14
申请号：US13637351
申请日：2011-03-29
申请人： Ulrika Egertsdotter , David Clapham
发明人： Ulrika Egertsdotter , David Clapham
IPC分类号： C12N5/04
CPC分类号： A01H4/005 , C12N5/0025
摘要： A method for the culture of somatic plant embryos comprising contacting said embryos with a culture medium containing a plasmolytic or near plasmolytic concentration of a sugar alcohol or a combination of sugar alcohols; and culturing said embryos in said culture medium for a time period suitable for the desired level of maturation to be achieved. Inositol is a preferable sugar alcohol.
摘要翻译： 一种用于培养体细胞植物胚胎的方法，包括使所述胚胎与含有溶血或近等离子体溶解浓度的糖醇或糖醇组合的培养基接触; 并在所述培养基中培养所述胚胎适合达到所需成熟水平的时间。 肌醇是优选的糖醇。
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公开(公告)号：US07790845B2
公开(公告)日：2010-09-07
申请号：US10494783
申请日：2002-11-05
申请人： David Clapham , Dejian Ren
发明人： David Clapham , Dejian Ren
IPC分类号： C07K14/195
CPC分类号： C07K14/32 , Y10S530/825
摘要： The present invention relates to a functionally expressed bacterial voltage-sensitive ion-selective channel. The novel channel can be used in conjunction with mammalian ion channel pore-containing regions in assays for screening for compounds that modulate activity of the channel. One bacterial ion channel of the present invention, called NaChBac, is derived from Bacillus halodurans (GenBank#BAB05220 (8)).
摘要翻译： 本发明涉及功能表达的细菌电压敏感离子选择性通道。 新颖的通道可以与用于筛选调节通道活性的化合物的测定法中的哺乳动物离子通道含孔区结合使用。 称为NaChBac的本发明的一种细菌离子通道来自嗜碱性芽孢杆菌（GenBank＃BAB05220（8））。
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公开(公告)号：US20090104604A1
公开(公告)日：2009-04-23
申请号：US12021474
申请日：2008-01-29
申请人： Dejian REN , David CLAPHAM , David L. GARBERS , Timothy A. QUILL
发明人： Dejian REN , David CLAPHAM , David L. GARBERS , Timothy A. QUILL
CPC分类号： A01K67/0278 , A01K2217/052 , A01K2227/105 , A01K2267/03 , A61K35/12 , A61K38/00 , A61K38/177 , C07K14/4715 , C07K14/705 , C12Q1/6881 , G01N33/689 , Y10S530/852
摘要： Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.
摘要翻译： 公开了与精子特异性的阳离子通道相关的核酸和蛋白质序列（CatSper2）。 显示CatSper2蛋白在精子中特异性表达。 公开了与CatSper2基因和蛋白相关的核酸，载体，转化细胞，转基因动物，多肽和抗体。 还提供了体外受精和避孕方法，鉴定CatSper2活性的调节剂的方法，关于CatSper2的受试者的基因分型方法，诊断和治疗CatSper2介导的障碍（包括不育症）的方法，以及与 CatSper2介导的疾病。
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4.发明授权Neuroprotective therapeutics preventing ERK/MAPK activation through the NMDA receptor 失效通过NMDA受体阻止ERK / MAPK激活的神经保护治疗剂公开(公告)号：US07425614B2
公开(公告)日：2008-09-16
申请号：US11181330
申请日：2005-07-14
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/70571 , C07K16/286 , G01N33/502 , G01N33/5058 , G01N33/9406 , G01N2333/70571 , G01N2333/82 , G01N2500/00 , G01N2510/00
摘要： Methods for identifying neuroprotective compounds, as well as compositions and methods for treating subjects suffering from neurological diseases or disorders are provided.
摘要翻译： 提供了用于鉴定神经保护性化合物的方法，以及用于治疗患有神经疾病或病症的受试者的组合物和方法。
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公开(公告)号：US20080070973A1
公开(公告)日：2008-03-20
申请号：US11765478
申请日：2007-06-20
申请人： Clare Anderton , David Clapham , Trevor Keel , Leanda Kindon
发明人： Clare Anderton , David Clapham , Trevor Keel , Leanda Kindon
IPC分类号： A61K31/40 , A61P25/00 , A61P25/18 , C07D207/00
CPC分类号： C07D207/06
摘要： The succinate and napadisylate salts and solvates of 2-(Methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide, 6-bis(trifluoromethy)benzamide napadisylate, and uses thereof in the treatment of disorders relating to GlyT1 transporter, such as schizophrenia, are disclosed.
摘要翻译： 2-（甲氧基）-N- [2-甲基-1-苯基-2-（1-吡咯烷基）丙基] -4,6-双（三氟甲基）苯甲酰胺，6-双（三氟甲基）苯甲酰胺的琥珀酸盐和萘二磺酸盐和溶剂合物 ）苯甲酰胺萘二甲酸盐，及其用于治疗与GlyT1转运蛋白相关的疾病如精神分裂症的用途。
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公开(公告)号：US20060035283A1
公开(公告)日：2006-02-16
申请号：US11181330
申请日：2005-07-14
IPC分类号： G01N33/53 , C07K14/705
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/70571 , C07K16/286 , G01N33/502 , G01N33/5058 , G01N33/9406 , G01N2333/70571 , G01N2333/82 , G01N2500/00 , G01N2510/00
摘要： Methods for identifying neuroprotective compounds, as well as compositions and methods for treating subjects suffering from neurological diseases or disorders are provided.
摘要翻译： 提供了用于鉴定神经保护性化合物的方法，以及用于治疗患有神经疾病或病症的受试者的组合物和方法。
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公开(公告)号：US09125352B2
公开(公告)日：2015-09-08
申请号：US13637351
申请日：2011-03-29
申请人： Ulrika Egertsdotter , David Clapham
发明人： Ulrika Egertsdotter , David Clapham
CPC分类号： A01H4/005 , C12N5/0025
摘要： A method for the culture of somatic plant embryos comprising contacting said embryos with a culture medium containing a plasmolytic or near plasmolytic concentration of a sugar alcohol or a combination of sugar alcohols; and culturing said embryos in said culture medium for a time period suitable for the desired level of maturation to be achieved. Inositol is a preferable sugar alcohol.
摘要翻译： 一种用于培养体细胞植物胚胎的方法，包括使所述胚胎与含有糖醇或糖醇组合的等离子溶解或近等离子体溶解浓度的培养基接触; 并在所述培养基中培养所述胚胎适合达到所需成熟水平的时间。 肌醇是优选的糖醇。
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公开(公告)号：US20110136798A1
公开(公告)日：2011-06-09
申请号：US13056775
申请日：2009-08-04
IPC分类号： A61K31/5383 , C07D498/04 , A61P25/24 , A61P25/22
CPC分类号： C07D498/04
摘要： The invention relates to 4-methylbenzenesulfonate salt of the compound of formula (I) in a crystalline form or a solvate thereof, pharmaceutical formulations containing them, their use in therapy and processes for preparing the same.
摘要翻译： 本发明涉及结晶形式或其溶剂合物的式（I）化合物的4-甲基苯磺酸盐，含有它们的药物制剂，它们在治疗中的用途及其制备方法。
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公开(公告)号：US20050202539A1
公开(公告)日：2005-09-15
申请号：US11078188
申请日：2005-03-11
申请人： Jayhong Chong , Magdalene Moran , David Clapham
发明人： Jayhong Chong , Magdalene Moran , David Clapham
CPC分类号： C07K14/705 , G01N33/6872
摘要： The present invention provides methods and compositions for expressing eukaryotic membrane proteins.
摘要翻译： 本发明提供用于表达真核细胞膜蛋白的方法和组合物。
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公开(公告)号：US20050142566A1
公开(公告)日：2005-06-30
申请号：US10828975
申请日：2004-04-21
申请人： Dejian Ren , David Clapham , David Garbers , Timothy Quill
发明人： Dejian Ren , David Clapham , David Garbers , Timothy Quill
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P15/08 , A61P15/16 , A61P15/18 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/06 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C07H21/04 , C07K16/28
CPC分类号： C07K14/705
摘要： Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.
摘要翻译： 公开了与精子特异性的阳离子通道相关的核酸和蛋白质序列（CatSper2）。 显示CatSper2蛋白在精子中特异性表达。 公开了与CatSper2基因和蛋白相关的核酸，载体，转化细胞，转基因动物，多肽和抗体。 还提供了体外受精和避孕方法，鉴定CatSper2活性的调节剂的方法，关于CatSper2的受试者的基因分型方法，诊断和治疗CatSper2介导的障碍（包括不育症）的方法，以及与 CatSper2介导的疾病。
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