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    Self-locking tissue cinching suture system
    1.
    发明授权
    Self-locking tissue cinching suture system 有权

    公开(公告)号：US11229428B2

    公开(公告)日：2022-01-25

    申请号：US16060366

    申请日：2017-03-07

    Applicant: Jeffrey David Jackson

    Inventor： Jeffrey David Jackson

    IPC: A61B17/04 ,  A61B17/06 ,  A61F2/08

    Abstract: A suture implant can include one or more suture cords having: a splice; a first free end extending from a first end of the at least one splice; an adjustable first loop extending from a second end of the at least one splice; a second free end extending from a first end of the at least one splice; a needled second loop having a cord portion extending from the first end of the at least one splice; a needle on the needled second loop; and an adjustable third loop extending from a second end of the at least one splice that has the second free end extending from the first end, wherein the second free end is connected to the adjustable third loop, wherein the adjustable first loop and adjustable third loop are interconnected and looped around each other.

    String pulling mechanisms for stringed musical instruments and related methods
    3.
    发明申请
    String pulling mechanisms for stringed musical instruments and related methods 审中-公开

    公开(公告)号：US20190019478A1

    公开(公告)日：2019-01-17

    申请号：US15875877

    申请日：2018-01-19

    Applicant: David Jackson

    Inventor： David Jackson

    IPC: G10D3/14

    Abstract: Disclosed are apparatus and related methods for adjusting the pitch of a string on a stringed instrument. In one embodiment, the disclosed devices enable a musician to adjust the tautness and, accordingly, the pitch of individual strings of a stringed instrument by simply pushing a lever or rotating a threaded piston or on or adjacent to the bridge of the guitar. The disclosed devices can preferably be outfitted on electric or acoustic stringed instruments, including guitars. The more specific aspects of the preferred embodiments are discussed in greater detail with reference to the figures.

    Systems and methods for identifying unknown drug targets via adverse event data
    6.
    发明授权
    Systems and methods for identifying unknown drug targets via adverse event data 有权
    通过不良事件数据识别未知药物靶标的系统和方法

    公开(公告)号：US09218457B2

    公开(公告)日：2015-12-22

    申请号：US13446871

    申请日：2012-04-13

    Applicant: David Jackson ,  Theodoros Soldatos ,  Guillaume Taglang ,  Alexander Zien ,  Stephan Brock

    Inventor： David Jackson ,  Theodoros Soldatos ,  Guillaume Taglang ,  Alexander Zien ,  Stephan Brock

    IPC: G01N31/00 ,  G06F19/00 ,  G06F19/18

    CPC classification number: G06F19/345 ,  G06F19/00 ,  G06F19/18 ,  G06F19/326 ,  G06F19/3437 ,  G16H50/20 ,  G16H50/50

    Abstract: The present disclosure is directed to systems and methods for identifying unknown drug targets via adverse event data. An analyzer receives an identification of a first drug having one or more unknown target proteins and identifies a second drug related to the first drug. The analyzer retrieves, from an adverse event database, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug. The analyzer generates a third side effect profile including a subset of the first side effect profile not shared by the second side effect profile, and identifies a third drug having a fourth side effect profile including the third side effect profile. The analyzer retrieves a list of one or more target proteins of the third drug not targeted by the second drug, and presents the retrieved list as potential target proteins of the first drug.

    Abstract translation: 本公开涉及用于通过不良事件数据识别未知药物靶标的系统和方法。 分析仪接收具有一种或多种未知目标蛋白质的第一种药物的鉴定，并识别与第一种药物相关的第二种药物。 分析仪从不良事件数据库检索与第一药物相关联的第一副作用谱，以及与第二药物相关联的第二副作用谱。 分析仪产生包括第二副作用轮廓不共享的第一副作用轮廓的子集的第三副作用轮廓，并且识别具有包括第三副作用轮廓的第四副作用轮廓的第三药物。 分析仪检索第二种药物未靶向的第三种药物的一种或多种靶蛋白的列表，并将检索到的列表作为第一种药物的潜在靶蛋白。

    SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS
    8.
    发明申请
    SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS 有权
    合成免疫用于生成长期放射免疫和防治病原体

    公开(公告)号：US20130183377A1

    公开(公告)日：2013-07-18

    申请号：US13822881

    申请日：2011-09-14

    Applicant: Javed Naim Agrewala ,  Uthaman Gowthaman ,  David Jackson ,  Weiguang Zeng

    Inventor： Javed Naim Agrewala ,  Uthaman Gowthaman ,  David Jackson ,  Weiguang Zeng

    IPC: C07K19/00

    CPC classification number: C07K19/00 ,  A61K39/04 ,  A61K2039/55516 ,  A61K2039/6018 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/484

    Abstract: The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, AIDS, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent HLA restriction in humans and livestock. The invention further relates to a vaccine comprising the said immunogen for generating enduring protective immunity against various diseases. The said vaccine is targeted against intracellular pathogens, more particularly the pathogen M. tuberculosis in this case. In the present invention, promiscuous peptides of M. tuberculosis are conjugated to TLR ligands especially; Pam2Cys to target them mainly to dendritic cells and therefore elicit long-lasting protective immunity. (The formula (I) should be inserted here) General formula (I) wherein, X1=a promiscuous CD4 T helper epitope selected from SEQ ID No. 1 to 98 OR nil; X2=a promiscuous CD8 T cytotoxic epitope selected from SEQ ID No. 99 to 103 OR nil; when X1=nil; X2=SEQ ID No. 99 to 103 and when X2=nil; X1=SEQ ID No. 1 to 98; Y=Lysine; and S=Serine.

    Abstract translation: 本发明涉及由通式1表示的合成免疫原，其可用于产生针对结核病，利什曼原虫病，艾滋病，艾滋病，锥虫病，疟疾和过敏，癌症的致病因子的各种细胞内病原体的长期保护性免疫，以及用于 其制备。 发达的免疫原能够规避人类和家畜的HLA限制。 本发明还涉及包含所述免疫原的疫苗，用于产生针对各种疾病的持久的保护性免疫。 在这种情况下，所述疫苗针对细胞内病原体，特别是病原体结核分枝杆菌。 在本发明中，结核分枝杆菌杂交肽特别与TLR配体结合; Pam2Cys将其主要靶向树突细胞，从而引发持久的保护性免疫。 （式（I）应在此插入）通式（I）其中X1 =选自SEQ ID No.1至98的杂交CD4T辅助表位或无; X2 =选自SEQ ID NO：99至103的混杂CD8 T细胞毒性表位或无; 当X1 = nil; X2 = SEQ ID No.99至103，当X2 = nil时; X1 = SEQ ID No.1至98; Y =赖氨酸; 和S =丝氨酸。

    SYSTEMS AND METHODS FOR USING ADVERSE EVENT DATA TO PREDICT POTENTIAL SIDE EFFECTS
    9.
    发明申请
    SYSTEMS AND METHODS FOR USING ADVERSE EVENT DATA TO PREDICT POTENTIAL SIDE EFFECTS 有权
    使用不良事件数据预测潜在影响的系统和方法

    公开(公告)号：US20130179138A1

    公开(公告)日：2013-07-11

    申请号：US13446912

    申请日：2012-04-13

    Applicant: David Jackson ,  Theodoros Soldatos ,  Guillaume Taglang ,  Alexander Zien ,  Stephan Brock

    Inventor： David Jackson ,  Theodoros Soldatos ,  Guillaume Taglang ,  Alexander Zien ,  Stephan Brock

    IPC: G06G7/58

    CPC classification number: G06F19/345 ,  G06F19/00 ,  G06F19/18 ,  G06F19/326 ,  G06F19/3437 ,  G16H50/20 ,  G16H50/50

    Abstract: The present disclosure describes systems and methods for predicting a likely side effect profile for even new, untested medications. A predicted side effect profile may be generated based on intersections of side effect profiles of other medications that affect the same or related molecular entities, such as the nearby target proteins, involve the same pathways, or are otherwise similarly related. To generate a predicted side effect profile for a new drug targeting a novel or previously un-targeted protein target, an analyzer may query an adverse event database for records pertaining to patients who have taken drugs or combinations of drugs that target or affect molecular entities in the vicinity of the novel target within a global molecular entity graph, and, in some embodiments, may retrieve a plurality of adverse event records and generate an intersection of side effects associated with related targets to predict likely side effects for the novel target.

    Abstract translation: 本公开描述了用于预测甚至新的未经检验的药物的可能的副作用特征的系统和方法。 可以基于影响相同或相关分子实体的其它药物（例如附近靶蛋白，涉及相同途径）的副作用分布的交叉点或者以其他方式相似的方式产生预测的副作用分布。 为了产生针对新颖或先前未靶向的蛋白质靶标的新药物的预测副作用特征，分析器可以查询不良事件数据库以获得关于已经服用药物或靶向或影响分子实体的药物组合的患者的记录 在全局分子实体图中的新靶标的附近，并且在一些实施例中，可以检索多个不利事件记录并产生与相关目标相关联的副作用的交集，以预测新颖目标的可能副作用。

    Compression style mid-span ground clamp
    10.
    发明授权
    Compression style mid-span ground clamp 失效
    压缩式中跨接地夹

    公开(公告)号：US08366459B2

    公开(公告)日：2013-02-05

    申请号：US13076815

    申请日：2011-03-31

    Applicant: Noah Montena ,  David Jackson

    Inventor： Noah Montena ,  David Jackson

    IPC: H01R4/66

    CPC classification number: H01R4/646 ,  H01R9/0524 ,  H02G15/025 ,  Y10T29/49123

    Abstract: A grounding clamp positioned on a coaxial cable at a location other than an end of the coaxial cable, wherein the grounding clamp includes an outer shell having a radial relationship with an elastomeric sleeve, the elastomeric sleeve being radially disposed over a conductive bonding contact, the conductive bonding contact being radially disposed over an outer conductive portion of the coaxial cable, wherein axial compression of the grounding clamp facilitates electrical contact between the outer shell and the conductive bonding contact and between the conductive bonding contact and the outer conductive portion of the coaxial cable. Furthermore, an associated method for maintaining ground continuity is also provided.

    Abstract translation: 一个位于同轴电缆上的位于不同于同轴电缆的端部的位置处的接地夹具，其中接地夹具包括与弹性体套筒具有径向关系的外壳，弹性套管径向设置在导电接合触头上， 导电接合接触件径向地设置在同轴电缆的外部导电部分上，其中接地夹的轴向压缩有助于外壳和导电接合接触之间以及导电接合接触和同轴电缆的外部导电部分之间的电接触 。 此外，还提供了一种用于维持接地连续性的相关方法。

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