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公开(公告)号:US20160251407A1
公开(公告)日:2016-09-01
申请号:US15025912
申请日:2014-10-02
申请人: Songnian LIN , Lin YAN , Ahmet KEKEC , Yuping ZHU , David N. HUNTER , Pei HUO , Danqing FENG , Ravi P. NARGUND , Christopher R. MOYES , Zhiqiang ZHAO , Brenda PIPIK , Dimitri PISSARNITSKI , Joseph L. DUFFY , Erin N. GUIDRY , MERCK SHARP & DOHME CORP.
发明人: Songnian Lin , Lin Yan , Ahmet Kekec , Yuping Zhu , David N. Hunter , Pei Huo , Danqing Feng , Ravi P. Nargund , Christopher R. Moyes , Zhiqiang Zhao , Brenda Pipik , Dmitri Pissarnitski , Joseph L. Duffy , Erin Guidry
CPC分类号: A61K47/61 , A61K38/28 , A61K47/549 , A61K47/64 , C07K14/62
摘要: Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
摘要翻译: 胰岛素缀合物包含共价连接到具有两个臂的至少一个双齿连接体的胰岛素分子,每个臂独立地连接到包含糖的配体,并且其中至少一个连接体的配体是岩藻糖。 胰岛素缀合物显示药代动力学(PK)和/或药效学(PD)谱,其对糖类如葡萄糖或α-甲基甘露糖的全身浓度有反应,即使在不存在外源多价的情况下施用于有需要的受试者时 糖结合分子如Con A.
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公开(公告)号:US20220242847A1
公开(公告)日:2022-08-04
申请号:US17611448
申请日:2020-05-18
申请人: Antonella CONVERSO , Abdellatif EL MARROUNI , Ashley FORSTER , Jessica L. FRIE , David N. HUNTER , Cheng WANG , Deping WANG , Merck Sharp & Dohme Corp.
发明人: Antonella Converso , Abdellatif El Marrouni , Ashley Forster , Jessica L. Frie , David N. Hunter , Cheng Wang , Deping Wang
IPC分类号: C07D401/06 , C07D401/14 , A61K45/06 , A61K31/506 , A61P31/18
摘要: The present disclosure is directed to pyridinone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
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