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公开(公告)号：US20130090286A1
公开(公告)日：2013-04-11
申请号：US13567858
申请日：2012-08-06
IPC分类号： C07K14/605
CPC分类号： C07K14/605
摘要： Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).
摘要翻译： 公开了相对于天然胰高血糖素在胰高血糖素受体上具有增强的效力的改良的胰高血糖素肽。 通过形成分子内桥或通过酰胺基取代末端羧酸对胰高血糖素肽进一步修饰产生显示胰高血糖素/ GLP-1受体共激动剂活性的肽。 通过聚乙二醇化，酰化，烷基化，羧基末端氨基酸的取代，C-末端截短或加入选自下组的羧基末端肽，可以进一步改善这些高效胰高血糖素类似物的溶解度和稳定性 由SEQ ID NO：26（GPSSGAPPPS），SEQ ID NO：27（KRNRNNIA）和SEQ ID NO：28（KRNR）组成。
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2.发明申请公开(公告)号：US20050125620A1
公开(公告)日：2005-06-09
申请号：US10731996
申请日：2003-12-09
申请人： Balaji Parthasarathy , David Smiley
发明人： Balaji Parthasarathy , David Smiley
CPC分类号： G06F12/0215
摘要： A method and apparatus for balancing memory access latency and bandwidth is generally described. In accordance with one example embodiment of the invention, a method comprising determining at least one characteristic of a memory request, and selectively leaving an accessed memory page open after a memory access based, at least in part, on the at least one characteristic for the memory request, to balance memory access latency and bandwidth of a subsequent memory request(s).
摘要翻译： 通常描述用于平衡存储器访问延迟和带宽的方法和装置。 根据本发明的一个示例性实施例，一种方法包括确定存储器请求的至少一个特征，以及至少部分地基于至少一个特性，在存储器访问之后选择性地使访问的存储器页面打开 存储器请求，以平衡存储器访问延迟和后续存储器请求的带宽。
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公开(公告)号：US20070105759A1
公开(公告)日：2007-05-10
申请号：US10556689
申请日：2004-06-17
申请人： David Flora , Mark Heiman , JeAnne Hertel , Hansen Hsiung , John Mayer , David Smiley , Liang Yan , Lianshan Zhang
发明人： David Flora , Mark Heiman , JeAnne Hertel , Hansen Hsiung , John Mayer , David Smiley , Liang Yan , Lianshan Zhang
摘要： The present invention relates to peptide agonists of the MC4 receptor, and as such are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and male and/or female sexual dysfunction.
摘要翻译： 本发明涉及MC4受体的肽激动剂，因此可用于治疗对该受体的活化有响应的病症，例如肥胖症，糖尿病和男性和/或女性性功能障碍。
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4.发明授权System and method for providing a list of monetary instruments associated with a system 有权提供与系统相关联的货币工具清单的系统和方法公开(公告)号：US08771057B2
公开(公告)日：2014-07-08
申请号：US11561074
申请日：2006-11-17
IPC分类号： A63F13/00
CPC分类号： G07F17/3244 , G07F17/32
摘要： A system has one or more gaming devices including gaming machines and other devices. At least one transaction reading device is coupled to the gaming devices and reads information associated with the monetary instruments associated with the gaming devices. A host computer is operatively coupled to the transaction reading device. A database is associated with the host computer and is configured to retrievably store the information associated with monetary instruments. A data display device is operatively coupled to the host computer and retrieves and displays a list of the monetary instruments in response to input from a user. The data display device can be associated with a wireless remote device, wired to the host computer or associated with the gaming device. The list of the monetary instruments includes information associated with each of the monetary instruments. The list of the monetary instruments can include information from selected gaming devices.
摘要翻译： 系统具有一个或多个游戏设备，包括游戏机和其他设备。 至少一个交易阅读设备被耦合到游戏设备并且读取与与游戏设备相关联的货币工具相关联的信息。 主计算机可操作地耦合到交易读取装置。 数据库与主机相关联，并被配置为可检索地存储与货币工具相关联的信息。 数据显示设备可操作地耦合到主计算机，并且响应于来自用户的输入检索和显示货币工具的列表。 数据显示设备可以与无线远程设备相关联，无线远程设备连接到主计算机或与游戏设备相关联。 货币工具清单包括与每种货币工具相关的信息。 货币清单可以包括来自所选游戏设备的信息。
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5.发明授权公开(公告)号：US07165161B2
公开(公告)日：2007-01-16
申请号：US10731996
申请日：2003-12-09
申请人： Balaji Parthasarathy , David Smiley
发明人： Balaji Parthasarathy , David Smiley
CPC分类号： G06F12/0215
摘要： A method and apparatus for balancing memory access latency and bandwidth is generally described. In accordance with one example embodiment of the invention, a method comprising determining at least one characteristic of a memory request, and selectively leaving an accessed memory page open after a memory access based, at least in part, on the at least one characteristic for the memory request, to balance memory access latency and bandwidth of a subsequent memory request(s).
摘要翻译： 通常描述用于平衡存储器访问延迟和带宽的方法和装置。 根据本发明的一个示例性实施例，一种方法包括确定存储器请求的至少一个特征，以及至少部分地基于至少一个特性，在存储器访问之后选择性地使访问的存储器页面打开 存储器请求，以平衡存储器访问延迟和后续存储器请求的带宽。
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公开(公告)号：US08969294B2
公开(公告)日：2015-03-03
申请号：US13567858
申请日：2012-08-06
IPC分类号： A61K38/26 , A61K38/12 , A61K38/00 , C07K14/605
CPC分类号： C07K14/605
摘要： Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).
摘要翻译： 公开了相对于天然胰高血糖素在胰高血糖素受体上具有增强的效力的改良的胰高血糖素肽。 通过形成分子内桥或通过酰胺基取代末端羧酸对胰高血糖素肽进一步修饰产生显示胰高血糖素/ GLP-1受体共激动剂活性的肽。 通过聚乙二醇化，酰化，烷基化，羧基末端氨基酸的取代，C-末端截短或加入选自下组的羧基末端肽，可以进一步改善这些高效胰高血糖素类似物的溶解度和稳定性 由SEQ ID NO：26（GPSSGAPPPS），SEQ ID NO：27（KRNRNNIA）和SEQ ID NO：28（KRNR）组成。
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7.发明申请SYSTEM AND METHOD FOR PROVIDING A LIST OF MONETARY INSTRUMENTS ASSOCIATED WITH A SYSTEM 有权提供与系统相关的货币单据清单的系统和方法公开(公告)号：US20070111793A1
公开(公告)日：2007-05-17
申请号：US11561074
申请日：2006-11-17
IPC分类号： A63F13/00
CPC分类号： G07F17/3244 , G07F17/32
摘要： A system has one or more gaming devices including gaming machines and other devices. At least one transaction reading device is coupled to the gaming devices and reads information associated with the monetary instruments associated with the gaming devices. A host computer is operatively coupled to the transaction reading device. A database is associated with the host computer and is configured to retrievably store the information associated with monetary instruments. A data display device is operatively coupled to the host computer and retrieves and displays a list of the monetary instruments in response to input from a user. The data display device can be associated with a wireless remote device, wired to the host computer or associated with the gaming device. The list of the monetary instruments includes information associated with each of the monetary instruments. The list of the monetary instruments can include information from selected gaming devices.
摘要翻译： 系统具有一个或多个游戏设备，包括游戏机和其他设备。 至少一个交易阅读设备被耦合到游戏设备并且读取与与游戏设备相关联的货币工具相关联的信息。 主计算机可操作地耦合到交易读取装置。 数据库与主机相关联，并被配置为可检索地存储与货币工具相关联的信息。 数据显示设备可操作地耦合到主计算机，并且响应于来自用户的输入检索和显示货币工具的列表。 数据显示设备可以与无线远程设备相关联，无线远程设备连接到主计算机或与游戏设备相关联。 货币工具清单包括与每种货币工具相关的信息。 货币清单可以包括来自所选游戏设备的信息。
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