公开(公告)号：US07935102B2

公开(公告)日：2011-05-03

申请号：US12317127

申请日：2008-12-19

申请人： Eugene M. Breznock ,  Jay A. Lenker ,  David W. Wieting

发明人： Eugene M. Breznock ,  Jay A. Lenker ,  David W. Wieting

IPC分类号： A61M31/00 ,  A61M1/00

CPC分类号： A61M5/36

摘要： A system for preventing air from entering a first catheter of a multi-catheter system. Air is prevented from entering the proximal end of the first catheter by an axially elongate chamber having an impeller, the chamber being affixed to the proximal end of the first catheter. The air is removed through a port near the centerline of the chamber. Liquid removed with the air is returned to the chamber to minimize liquid loss during the procedure. A second catheter inserted through the chamber and into the first catheter is unable to entrain gas into the first catheter because any gas that enters the chamber is routed to the centerline of the chamber where it is removed. Inflow of fluid from an external pump scrubs the second catheter shaft of air bubbles attached by surface tension.

摘要翻译： 一种用于防止空气进入多导管系统的第一导管的系统。 通过具有叶轮的轴向细长室防止空气进入第一导管的近端，该腔室固定到第一导管的近端。 空气通过靠近室的中心线的端口移除。 用空气除去的液体返回到室中，以最小化在该过程中的液体损失。 插入通过腔室并进入第一导管的第二导管不能将气体夹带到第一导管中，因为进入腔室的任何气体被引导到其被移除的腔室的中心线。 来自外部泵的流体的流入通过表面张力擦拭附着的气泡的第二导管轴。

公开(公告)号：US07824356B2

公开(公告)日：2010-11-02

申请号：US12322594

申请日：2009-02-04

申请人： David W. Wieting ,  Jay A. Lenker

发明人： David W. Wieting ,  Jay A. Lenker

IPC分类号： A61M37/00 ,  A61M1/00 ,  B01D21/26 ,  B01D33/15 ,  B01D33/27

CPC分类号： A61M1/3633 ,  A61M1/1658 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3666 ,  A61M1/3667 ,  A61M5/36 ,  A61M2205/75 ,  A61M2205/7527 ,  A61M2206/16 ,  B01D19/0031 ,  B01D19/0057 ,  B01D19/0094 ,  B01D2247/10 ,  B01D2247/101 ,  B01D2247/108 ,  B04C3/00 ,  B04C3/06 ,  B04C5/02 ,  B04C5/04 ,  B04C5/08 ,  B04C5/107 ,  B04C9/00 ,  B04C2009/004 ,  B04C2009/007

摘要： A system is disclosed for removing gas bubbles from blood during circulatory assist procedures. Such bubbles are generated, along with particulate matter, in an extracorporeal circulatory bypass system by the pump, oxygenator and other components. Filters are used in the line to remove particulates and bubbles from the blood before they are pumped back to the patient but current filters are inefficient at removing small bubbles and debris that can cause neurological defects and renal and other organ failures in the patient. An active filter apparatus and method is disclosed that forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter. The filter comprises an axially elongate cylindrical shell with a blood inlet, a blood outlet and a gas outlet. A motor driven impeller spins the blood within the shell and forces the gas toward the center by centripetal force, utilizing the buoyancy effects of the bubbles in blood, whereby the bubbles can be bled off at the center of the filter element.

摘要翻译： 公开了一种在循环辅助过程中从血液中除去气泡的系统。 这些气泡与颗粒物质一起通过泵，氧合器和其它组分在体外循环旁路系统中产生。 在使用过滤器从血液中除去颗粒和气泡之前，将其抽回患者，但是当前的过滤器在除去可能导致神经缺陷和患者的肾脏和其他器官衰竭的小气泡和碎屑时效率低下。 公开了一种有源过滤装置和方法，其将气泡迫使系统的中心，在血液离开过滤器之前将其从血液中取出。 过滤器包括具有血液入口，血液出口和气体出口的轴向细长的圆柱形壳体。 马达驱动的叶轮将壳体内的血液旋转并通过向心力将气体推向中心，利用血液中气泡的浮力作用，从而可以在过滤元件的中心排出气泡。

公开(公告)号：US20090173695A1

公开(公告)日：2009-07-09

申请号：US12322594

申请日：2009-02-04

申请人： David W. Wieting ,  Jay A. Lenker

发明人： David W. Wieting ,  Jay A. Lenker

IPC分类号： B01D21/26

CPC分类号： A61M1/3633 ,  A61M1/1658 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3666 ,  A61M1/3667 ,  A61M5/36 ,  A61M2205/75 ,  A61M2205/7527 ,  A61M2206/16 ,  B01D19/0031 ,  B01D19/0057 ,  B01D19/0094 ,  B01D2247/10 ,  B01D2247/101 ,  B01D2247/108 ,  B04C3/00 ,  B04C3/06 ,  B04C5/02 ,  B04C5/04 ,  B04C5/08 ,  B04C5/107 ,  B04C9/00 ,  B04C2009/004 ,  B04C2009/007

摘要： A system is disclosed for removing gas bubbles from blood during circulatory assist procedures. Such bubbles are generated, along with particulate matter, in an extracorporeal circulatory bypass system by the pump, oxygenator and other components. Filters are used in the line to remove particulates and bubbles from the blood before they are pumped back to the patient but current filters are inefficient at removing small bubbles and debris that can cause neurological defects and renal and other organ failures in the patient. An active filter apparatus and method is disclosed that forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter. The filter comprises an axially elongate cylindrical shell with a blood inlet, a blood outlet and a gas outlet. A motor driven impeller spins the blood within the shell and forces the gas toward the center by centripetal force, utilizing the buoyancy effects of the bubbles in blood, whereby the bubbles can be bled off at the center of the filter element.

摘要翻译： 公开了一种在循环辅助过程中从血液中除去气泡的系统。 这些气泡与颗粒物质一起通过泵，氧合器和其它组分在体外循环旁路系统中产生。 在使用过滤器从血液中除去颗粒和气泡之前，将其抽回患者，但是当前的过滤器在除去可能导致神经缺陷和患者的肾脏和其他器官衰竭的小气泡和碎屑时效率低下。 公开了一种有源过滤装置和方法，其将气泡迫使系统的中心，在血液离开过滤器之前将其从血液中取出。 过滤器包括具有血液入口，血液出口和气体出口的轴向细长的圆柱形壳体。 马达驱动的叶轮将壳体内的血液旋转并通过向心力将气体推向中心，利用血液中气泡的浮力作用，从而可以在过滤元件的中心排出气泡。

公开(公告)号：US5716398A

公开(公告)日：1998-02-10

申请号：US376624

申请日：1995-01-23

申请人： Robert Sparks ,  Chris Kingsbury ,  David W. Wieting

发明人： Robert Sparks ,  Chris Kingsbury ,  David W. Wieting

IPC分类号： A61F2/24

CPC分类号： A61F2/2409 ,  A61F2/2427 ,  A61F2/2403 ,  Y10S623/904

摘要： A valve rotator comprising a body having a generally annular peripheral surface at one end of the body and a central cavity opening at such end. The annular peripheral surface substantially surrounds the central cavity and has an interlocking surface region configured to interlock with a rotor of a rotatable valve. The body had a generally annular shoulder adjacent such one end which generally faces such end of the body. The annular peripheral surface extends toward that end of the body from the annular shoulder.

摘要翻译： 一种阀旋转器，包括主体，该主体在主体的一端具有大致环形的外周表面，在该端部具有中心腔。 环形周边表面基本上围绕中心腔并且具有构造成与可旋转阀的转子互锁的互锁表面区域。 主体具有大致环形的肩部，该肩部大致面向主体的这一端。 环形周边表面从环形肩部向本体的端部延伸。

公开(公告)号：US07488448B2

公开(公告)日：2009-02-10

申请号：US10791075

申请日：2004-03-01

申请人： David W. Wieting ,  Jay A. Lenker

发明人： David W. Wieting ,  Jay A. Lenker

IPC分类号： A61M1/00 ,  A61M37/00 ,  B01D53/24 ,  C02F1/44

CPC分类号： A61M1/3633 ,  A61M1/1658 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3666 ,  A61M1/3667 ,  A61M5/36 ,  A61M2205/75 ,  A61M2205/7527 ,  A61M2206/16 ,  B01D19/0031 ,  B01D19/0057 ,  B01D19/0094 ,  B01D2247/10 ,  B01D2247/101 ,  B01D2247/108 ,  B04C3/00 ,  B04C3/06 ,  B04C5/02 ,  B04C5/04 ,  B04C5/08 ,  B04C5/107 ,  B04C9/00 ,  B04C2009/004 ,  B04C2009/007

摘要： A system for removing gas bubbles from blood during circulatory assist procedures. An active filter apparatus forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter.

摘要翻译： 在循环辅助程序中从血液中除去气泡的系统。 有源过滤器装置迫使气泡到系统的中心，在血液离开过滤器之前，它们被从血液中取出。

公开(公告)号：US5272909A

公开(公告)日：1993-12-28

申请号：US691258

申请日：1991-04-25

申请人： Than Nguyen ,  Aws Nashef ,  Amir H. Abolfathi ,  David W. Wieting ,  Denis Lee

发明人： Than Nguyen ,  Aws Nashef ,  Amir H. Abolfathi ,  David W. Wieting ,  Denis Lee

IPC分类号： A61B17/00 ,  A61F2/24 ,  A61B5/00 ,  G01M19/00

CPC分类号： A61F2/2472 ,  A61B2017/00707

摘要： A method and device for testing artificial or natural venous valves. The device comprises (a) a fixture for mounting a sample valve on a liquid flow path, (b) a muscle pump component and/or (o) respiratory pump component and/or (d) capacitance reservoir component and/or (e) vertical hydrostatic column component, all of the components being fluidly connected to the flow path to mimic the muscle pump, respiratory pump, capacitance and hydrostatic impedance effects of actual in situ venous circulation in the mammalian body. The invention includes methods of testing venous valves by mimicking known hemodynamic flow conditions within a mammalian body.

摘要翻译： 用于测试人造或天然静脉瓣膜的方法和装置。 该装置包括：（a）用于将样品阀安装在液体流路上的夹具，（b）肌肉泵组件和/或（o）呼吸泵部件和/或（d）电容储存器部件和/或（e） 垂直静水柱组分，所有组分流体连接到流动路径以模拟哺乳动物体内实际原位静脉循环的肌肉泵，呼吸泵，电容和静水阻抗效应。 本发明包括通过模拟哺乳动物体内的已知血液动力学流动条件来测试静脉瓣的方法。

公开(公告)号：US08480606B2

公开(公告)日：2013-07-09

申请号：US12925922

申请日：2010-11-02

申请人： David W. Wieting ,  Jay A. Lenker

发明人： David W. Wieting ,  Jay A. Lenker

IPC分类号： A61M1/00 ,  A61M1/10 ,  A61M1/36 ,  B01D19/00

CPC分类号： A61M1/3633 ,  A61M1/1658 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3666 ,  A61M1/3667 ,  A61M5/36 ,  A61M2205/75 ,  A61M2205/7527 ,  A61M2206/16 ,  B01D19/0031 ,  B01D19/0057 ,  B01D19/0094 ,  B01D2247/10 ,  B01D2247/101 ,  B01D2247/108 ,  B04C3/00 ,  B04C3/06 ,  B04C5/02 ,  B04C5/04 ,  B04C5/08 ,  B04C5/107 ,  B04C9/00 ,  B04C2009/004 ,  B04C2009/007

摘要： A system is disclosed for removing gas bubbles from blood during circulatory assist procedures. Such bubbles are generated, along with particulate matter, in an extracorporeal circulatory bypass system by the pump, oxygenator and other components. Current filters are inefficient at removing small bubbles that can cause neurological defects and renal and other organ failures in the patient. An active filter apparatus and method is disclosed that forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter. The filter comprises an axially elongate cylindrical shell with a blood inlet, a blood outlet and a gas outlet. A motor driven impeller spins the blood within the shell and forces the gas toward the center by centripetal force, utilizing the buoyancy effects of the bubbles in blood, whereby the bubbles can be bled off at the center of the filter.

摘要翻译： 公开了一种在循环辅助过程中从血液中除去气泡的系统。 这些气泡与颗粒物质一起通过泵，氧合器和其它组分在体外循环旁路系统中产生。 电流过滤器在去除可能导致神经缺陷和患者中肾脏和其他器官衰竭的小气泡方面效率不高。 公开了一种有源过滤装置和方法，其将气泡迫使系统的中心，在血液离开过滤器之前将其从血液中取出。 过滤器包括具有血液入口，血液出口和气体出口的轴向细长的圆柱形壳体。 电机驱动的叶轮将壳体内的血液旋转并通过向心力将气体推向中心，利用气泡在血液中的浮力作用，从而可以在过滤器的中心排出气泡。

公开(公告)号：US5327774A

公开(公告)日：1994-07-12

申请号：US133701

申请日：1993-10-08

申请人： Than Nguyen ,  Aws Nashef ,  Amir H. Abolfathi ,  David W. Wieting ,  Denis Lee

发明人： Than Nguyen ,  Aws Nashef ,  Amir H. Abolfathi ,  David W. Wieting ,  Denis Lee

IPC分类号： A61B17/00 ,  A61F2/24

CPC分类号： A61F2/2472 ,  A61B2017/00707

摘要： A method and device for testing artificial or natural venous valves. The device comprises chamber (10) a sample for mounting a test valve (V) on a liquid flow path and a muscle pump component (16) and/or respiratory pump component (50) and/or capacitance reservoir (58) and/or vertical hydrostatic column component (102) fluidly connected to the flow path to mimic the muscle pump, respiratory pump, capacitance and hydrostatic impedance effects on venous circulation in the mammalian body. Included in the invention are methods of testing venous valves by mimicking known hemodynamic flow conditions within a mammalian body.

摘要翻译： 用于测试人造或天然静脉瓣膜的方法和装置。 该装置包括腔室（10），用于将液体流路上的测试阀（V）和肌肉泵组件（16）和/或呼吸泵部件（50）和/或电容容器（58）和/或 流体连接到流动路径的垂直静液压柱组件（102），以模拟肌肉泵，呼吸泵，电容和静水阻抗对哺乳动物体内静脉循环的影响。 本发明包括通过模拟哺乳动物体内已知的血液动力学流动条件来测试静脉瓣的方法。

公开(公告)号：US5035709A

公开(公告)日：1991-07-30

申请号：US502158

申请日：1990-03-29

申请人： David W. Wieting ,  Than Nguyen ,  Robert Stobie ,  Hung L. Lam ,  Ralph Kafesjian

发明人： David W. Wieting ,  Than Nguyen ,  Robert Stobie ,  Hung L. Lam ,  Ralph Kafesjian

IPC分类号： A61F2/24

CPC分类号： A61F2/2409

摘要： A mechanical heart valve having one or more leaflets pivotally fitted in a substantially cylindrical shaped valve body formed from a resiliently deformable material. A stiffening member formed from substantially nonresilient material fit about the valve body exterior wall to provide structural integrity to the valve body. Stresses which are normally applied to the heart valve body during the opening and closing of the valve are absorbed or cushioned by the incorporation of a rubber-like body between the stiffening member and the retainer member. Further cushioning is provided by incorporating another rubber-like body in the sewing ring. This second body extends out from the exterior surface of the valve body. Finally, a length of fabric is positioned about the retainer and shock absorbing bodies. This design provides a precisely calibrated rotational torque which allows for optimum orientation of the leaflets by the implanting surgeon.

摘要翻译： 机械式心脏瓣膜，其具有一个或多个可旋转地装配在由可弹性变形的材料形成的大致圆柱形的阀体中的传单。 由基本上非弹性材料形成的加强构件围绕阀体外壁安装，以向阀体提供结构完整性。 在阀门的打开和关闭期间通常施加到心脏瓣膜体的应力通过在加强构件和保持构件之间并入橡胶状体而被吸收或缓冲。 通过在缝合环中并入另一个橡胶状体来提供进一步的缓冲。 该第二主体从阀体的外表面延伸出来。 最后，将一定长度的织物定位在保持器和减震体周围。 该设计提供精确校准的旋转扭矩，其允许植入外科医生对瓣叶的最佳取向。

公开(公告)号：US20130053693A1

公开(公告)日：2013-02-28

申请号：US13568778

申请日：2012-08-07

申请人： Eugene M. Breznock ,  Jay A. Lenker ,  David W. Wieting

发明人： Eugene M. Breznock ,  Jay A. Lenker ,  David W. Wieting

IPC分类号： A61M5/36 ,  A61B6/00

CPC分类号： A61M5/36 ,  A61M1/3627 ,  A61M25/0097 ,  A61M39/0613

摘要： A system for preventing air from entering a first catheter of a multi-catheter system. Air is prevented from entering the proximal end of the first catheter by an axially elongate chamber having an impeller, the chamber being affixed to the proximal end of the first catheter. The air is removed through a port near the centerline of the chamber. Liquid removed with the air is returned to the chamber to minimize liquid loss during the procedure. A second catheter inserted through the chamber and into the first catheter is unable to entrain gas into the first catheter because any gas that enters the chamber is routed to the centerline of the chamber where it is removed. Inflow of fluid from an external pump scrubs the second catheter shaft of air bubbles attached by surface tension.

摘要翻译： 一种用于防止空气进入多导管系统的第一导管的系统。 通过具有叶轮的轴向细长室防止空气进入第一导管的近端，该腔室固定到第一导管的近端。 空气通过靠近室的中心线的端口移除。 用空气除去的液体返回到室中，以最小化在该过程中的液体损失。 插入通过腔室并进入第一导管的第二导管不能将气体夹带到第一导管中，因为进入腔室的任何气体被引导到其被移除的腔室的中心线。 来自外部泵的流体的流入通过表面张力擦拭附着的气泡的第二导管轴。