公开(公告)号：US06610696B2

公开(公告)日：2003-08-26

申请号：US10121373

申请日：2002-04-11

申请人： Dawn A. Brooks ,  Christopher J. Rito ,  Anthony J. Shuker ,  Samuel J. Dominianni ,  Alan M. Warshawsky ,  Lynn S. Gossett ,  Donald P. Matthews ,  David A. Hay ,  Robert J. Ardecky ,  Pierre-Yves Michellys ,  John S. Tyhonas

发明人： Dawn A. Brooks ,  Christopher J. Rito ,  Anthony J. Shuker ,  Samuel J. Dominianni ,  Alan M. Warshawsky ,  Lynn S. Gossett ,  Donald P. Matthews ,  David A. Hay ,  Robert J. Ardecky ,  Pierre-Yves Michellys ,  John S. Tyhonas

IPC分类号： A61K3142

CPC分类号： C07D413/10 ,  C07D263/32 ,  C07D277/24

摘要： The present invention is directed to compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof, and methods of making, methods of using and pharmaceutical compositions having compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof: In Structural Formula I, n is 2, 3, or 4; V is O or S; W is O, S, or SO2; R1 is H, a C1-C4 alkyl, phenyl or trifluoromethyl; R2 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, a cycloalkyl, or together with the phenyl to which they are bound form naphthyl or 1,2,3,4-tetrahydronaphthyl; R3 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, or a cycloalkyl; R4 are each, independently, H, a C1-C4 alkyl, an aryl, or benzyl; R5 are each, independently, H, a substituted or unsubstituted aryl or a heteroaryl, provided that at least one R5 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; and R6 is H, a C1-C4 alkyl, or an aminoalkyl.

公开(公告)号：US06825222B2

公开(公告)日：2004-11-30

申请号：US10434425

申请日：2003-05-07

申请人： Dawn A. Brooks ,  Christopher J. Rito ,  Anthony J. Shuker ,  Samuel J. Dominianni ,  Alan M. Warshawsky ,  Lynn S. Gossett ,  Donald P. Matthews ,  David A. Hay ,  Robert J. Ardecky ,  Pierre-Yves Michellys ,  John S. Tyhonas

发明人： Dawn A. Brooks ,  Christopher J. Rito ,  Anthony J. Shuker ,  Samuel J. Dominianni ,  Alan M. Warshawsky ,  Lynn S. Gossett ,  Donald P. Matthews ,  David A. Hay ,  Robert J. Ardecky ,  Pierre-Yves Michellys ,  John S. Tyhonas

IPC分类号： A61K31425

CPC分类号： C07D413/10 ,  C07D263/32 ,  C07D277/24

摘要： The present invention is directed to compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof, and methods of making, methods of using and pharmaceutical compositions having compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof: In Structural Formula I, n is 2, 3, or 4; V is O or S; W is O, S, or SO2; R1 is H, a C1-C4 alkyl, phenyl or trifluoromethyl; R2 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, a cycloalkyl, or together with the phenyl to which they are bound form naphthyl or 1,2,3,4-tetrahydronaphthyl; R3 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, or a cycloalkyl; R4 are each, independently, H, a C1-C4 alkyl, an aryl, or benzyl; R5 are each, independently, H, a substituted or unsubstituted aryl or a heteroaryl, provided that at least one R5 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; and R6 is H, a C1-C4 alkyl, or an aminoalkyl.

摘要翻译： 本发明涉及由结构式I表示的化合物及其药学上可接受的盐，溶剂合物和水合物及其制备方法，使用方法和具有由结构式I表示的化合物的药物组合物及其药学上可接受的盐，溶剂化物和水合物： 在结构式Ⅰ中，n为2,3或4; V为O或S; W是O，S或SO 2; R1是H，C1-C4烷基，苯基或三氟甲基; R 2各自独立地为H，C 1 -C 6烷基，芳基-C 1 -C 6烷基，环烷基-C 1 -C 4烷基，芳基，环烷基，或与它们所连接的苯基一起形成萘基或1 ，2,3,4-四氢萘基; R 3各自独立地为H，C 1 -C 6烷基，芳基-C 1 -C 6烷基，环烷基-C 1 -C 4烷基，芳基或环烷基; R 4各自独立地为H，C 1 -C 4烷基，芳基或苄基; R5各自独立地为H，取代或未取代的芳基或杂芳基，条件是至少一个R 5为取代或未取代的芳基或取代或未取代的杂芳基; 并且R 6是H，C 1 -C 4烷基或氨基烷基。

公开(公告)号：US06417212B1

公开(公告)日：2002-07-09

申请号：US09644457

申请日：2000-08-23

申请人： Dawn A. Brooks ,  Christopher J. Rito ,  Anthony J. Shuker ,  Samuel J. Dominianni ,  Alan M. Warshawsky ,  Lynn S. Gossett ,  Donald P. Matthews ,  David A. Hay ,  Robert J. Ardecky ,  Pierre-Yves Michellys ,  John S. Tyhonas

发明人： Dawn A. Brooks ,  Christopher J. Rito ,  Anthony J. Shuker ,  Samuel J. Dominianni ,  Alan M. Warshawsky ,  Lynn S. Gossett ,  Donald P. Matthews ,  David A. Hay ,  Robert J. Ardecky ,  Pierre-Yves Michellys ,  John S. Tyhonas

IPC分类号： C07D26336

CPC分类号： C07D413/10 ,  C07D263/32 ,  C07D277/24

摘要： The present invention is directed to compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof, and methods of making, methods of using and pharmaceutical compositions having compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof: In Structural Formula I, n is 2, 3, or 4; V is O or S; W is O, S, or SO2; R1 is H, a C1-C4 alkyl, phenyl or trifluoromethyl; R2 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, a cycloalkyl, or together with the phenyl to which they are bound form naphthyl or 1,2,3,4-tetrahydronaphthyl; R3 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, or a cycloalkyl; R4 are each, independently, H, a C1-C4 alkyl, an aryl, or benzyl; R5 are each, independently, H, a substituted or unsubstituted aryl or a heteroaryl, provided that at least one R5 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; and R6 is H, a C1-C4 alkyl, or an aminoalkyl.

摘要翻译： 本发明涉及由结构式I表示的化合物及其药学上可接受的盐，溶剂合物和水合物及其制备方法，使用方法和具有由结构式I表示的化合物的药物组合物及其药学上可接受的盐，溶剂化物和水合物： 在结构式I中，n为2,3或4; V为O或S; W是O，S或SO 2; R1是H，C1-C4烷基，苯基或三氟甲基; R 2各自独立地为H，C 1 -C 6烷基，芳基-C 1 -C 6烷基，环烷基-C 1 -C 4烷基，芳基，环烷基，或与它们所连接的苯基一起形成萘基或1 ，2,3,4-四氢萘基; R 3各自独立地为H，C 1 -C 6烷基，芳基-C 1 -C 6烷基，环烷基-C 1 -C 4烷基，芳基或环烷基; R 4各自独立地为H，C 1 -C 4烷基，芳基或苄基; R5各自独立地为H，取代或未取代的芳基或杂芳基，条件是至少一个R 5为取代或未取代的芳基或取代或未取代的杂芳基; 并且R 6是H，C 1 -C 4烷基或氨基烷基。