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    Bis-acyloxymethyl derivatives
    1.
    发明授权
    Bis-acyloxymethyl derivatives 失效
    双酰氧基甲基衍生物

    公开(公告)号：US5583148A

    公开(公告)日：1996-12-10

    申请号：US729986

    申请日：1991-07-15

    申请人： Wayne K. Anderson ,  Dennis C. Dean

    发明人： Wayne K. Anderson ,  Dennis C. Dean

    IPC分类号： A61K31/44 ,  A61P31/04 ,  A61P35/00 ,  C07D401/04 ,  C07D403/04 ,  C07D487/04 ,  C07D219/08 ,  A61K31/435 ,  C07D215/10 ,  C07D217/10

    CPC分类号： C07D401/04 ,  C07D487/04

    摘要： This invention relates to new pyridyl, quinoline and acridine bis-acyloxymethyl compounds; to compositions comprising these compounds; and to processes for their utility as fungicides, bactericides and as inhibitors of the growth of cancer in warm-blooded animals. In accordance with this invention, new bis-acyloxymethyl derivatives are provided of the formula: ##STR1## wherein B is selected from substituted and unsubstituted alkyl, cycloalkyl, aryl, alkenyl, cycloalkenyl and alkynyl; A is selected from hydrogen and B; or, A and B together comprise a pyrrolizine; L is selected from ##STR2## wherein Y is selected from hydrogen or ##STR3## each R and Z is independently selected from hydrogen or substituted and unsubstituted alkyl, cycloalkyl, aryl, alkenyl, cycloalkenyl, alkynyl, amine group, each Z' is independently selected from hydrogen and substituted or unsubstituted alkyl; M is Z or is selected from halogen, nitro, hydroxyl, nitrile and substituted or unsubstituted, carboxylic acid group, carboxylic acid ester group, carboxylic acid amide group, sulfonic acid group and sulfonic acid amide group; ether group, thioether group, acylated hydroxyl, sulfonylamide, sulfonylurea, sulfoxide group, sulfone group and mixtures thereof; each n is the same and is 0 or 1; q is from 0-4; and, X is the anion of an acid.

    摘要翻译： 本发明涉及新的吡啶基，喹啉和吖啶双酰氧基甲基化合物; 包含这些化合物的组合物; 以及作为杀真菌剂，杀菌剂和作为温血动物癌症生长抑制剂的作用的方法。 根据本发明，新的双酰氧基甲基衍生物由下式提供：其中B选自取代和未取代的烷基，环烷基，芳基，烯基，环烯基和炔基; A选自氢和B; 或者，A和B一起包含吡咯嗪; 每个R和Z独立地选自氢或取代和未取代的烷基，环烷基，芳基，烯基，环烯基，炔基，胺基，每个Z'独立地选自氢 和取代或未取代的烷基; M为Z或选自卤素，硝基，羟基，腈和取代或未取代的羧酸基，羧酸酯基，羧酸酰胺基，磺酸基和磺酸酰胺基; 醚基，硫醚基，酰化羟基，磺酰胺，磺酰脲，亚砜基，砜基及其混合物; 每个n相同，为0或1; q为0-4; 而X是酸的阴离子。