摘要:
The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要:
The present invention relates to substituted piperazine compounds that are useful modulators of muscarinic receptors. The present invention also provides compositions comprising such compounds, and methods for treating muscarinic receptor mediated diseases.
摘要:
The present invention relates to substituted piperazine compounds that are useful modulators of muscarinic receptors. The present invention also provides compositions comprising such compounds, and methods for treating muscarinic receptor mediated diseases.
摘要:
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要:
An electrical connection of a transfer station releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface. In the transfer station, a matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship. An elastomeric compression element, at the rear of the matching substrate, has individual protruding compression members contacting the rear surface and registered with corresponding individual electrical contacts. Elongated electrical contacts are registered with two adjacent individual compression members. A loader engages the portable cartridge, registering the cartridge substrate contacts in face-to-face relation with the matching flexible substrate electrical contacts, and exerting a normal force to the cartridge to compress the compression element and create non-wiping contact between the facing electrical contacts.
摘要:
An electrical connection releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface of a flex cable termination mounted on a backing plate. A matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship, and is mounted on a compression element with protruding compression members. Elongated electrical contacts are registered with two adjacent individual compression members. A loader exerts a normal force to the cartridge to compress the compression element and create non-wiping contact between the facing electrical contacts.
摘要:
The present invention relates to compounds useful as modulators of the vanilloid receptor, and also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要:
An indicator comprises a rotary device in the form of a right cylinder arranged to be rotatable in a chamber of a portable data storage cartridge, which has an exterior wall opening to the chamber. A peripheral surface of the rotary device has an encoded pattern of at least one cylindrical surface and a plurality of facets interrupting the cylindrical surface(s). The facets are located at various axial positions, and at various angularly spaced rotational positions, such that, at differing rotational positions of the rotary device, at least one or none of the facets is positioned at the exterior opening.
摘要:
A system for constructing golf course traps which would include the steps of forming a cutout area in the fairway in the desired shape of the trap, the cutout area including a continuous substantially vertical sidewall and a substantially flat floor portion; and forming a plurality of channels for housing the "turf drain" composite drainage line within the channels for undertaking drainage of the traps; prior to the placement of the turf drain lines within the channels, placing a continuous sheet of material such as plastic liner along the floor of the trap and the continuous sheet forming within the plurality of channels; positioning the "turf drain" composite drainage line within the channels so that the plastic liner is positioned between the soil and the turf drainage line; and filling the trap with sufficient sand for allowing the upper most portion space of the sand within the trap to be substantially flush with the surrounding fairway, so that as water drains into the trap, the water would essentially follow the vertical wall of the trap, and would drain along the plastic liner layer, and to the turf drain lines to be drained from the trap, without the water ever making contact with the soil beneath the plastic liner layer or turf drain line.
摘要:
A land drainage apparatus, system, and method utilize a vacuum pump and atmospheric pressure to lift water from a collection basin to a level above a fluid intake level. After a certain amount of water is lifted and collected in a second chamber above the level of the collection basin, the vacuum can be broken, enabling the water to flow out of the second chamber by gravity flow to an exit, wherein the exit is above the fluid level intake and below the second chamber.