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公开(公告)号:US07842718B2
公开(公告)日:2010-11-30
申请号:US12576513
申请日:2009-10-09
申请人: Anthony Frank Kreft , Derek Cecil Cole , Kevin R. Woller , Joseph Raymond Stock , George Diamantidis , Dennis Michael Kubrak , Kristina Martha Kutterer , William J. Moore , David S. Casebier
发明人: Anthony Frank Kreft , Derek Cecil Cole , Kevin R. Woller , Joseph Raymond Stock , George Diamantidis , Dennis Michael Kubrak , Kristina Martha Kutterer , William J. Moore , David S. Casebier
IPC分类号: A61K31/381 , C07D333/34
CPC分类号: C07D409/12 , C07D307/64 , C07D333/34
摘要: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's disease and Down's syndrome are described.
摘要翻译: 提供其中R1,R2,R3,R4,R5,R6,T,W,X,Y和Z如本文所定义的式(I)化合物及其药学上可接受的盐,水合物和/或前药。 描述了使用这些化合物抑制β淀粉样蛋白生成和治疗阿尔茨海默病和唐氏综合征的方法。