公开(公告)号：US12102671B2

公开(公告)日：2024-10-01

申请号：US15773653

申请日：2016-11-04

申请人： The USA, as represented by the Secretary, Department of Health and Human Services

发明人： Peter L. Collins ,  Ursula J. Buchholz

IPC分类号： A61K39/155 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55 ,  C12N2760/18523 ,  C12N2760/18534 ,  C12N2760/18571

摘要： Respiratory syncytial virus (RSV) infection may lead to severe respiratory illness in young children. Thus, there is a need for a live attenuated vaccine, which would mimic the natural course of infection without causing illness; however, restricting viral replication also reduces the immune response. Reported herein is a method of vaccination using a single dose of a recombinant RSV lacking the M2-2 protein that surprisingly induced a stronger immune response to RSV than previous vaccine candidates despite being more restricted in replication.

公开(公告)号：US20240316056A1

公开(公告)日：2024-09-26

申请号：US18735506

申请日：2024-06-06

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services ,  University of Kansas ,  Northwestern University

发明人： Udo Rudloff ,  Serguei Kozlov ,  Juan Jose Marugan ,  Sui Huang ,  Samarjit Patnaik ,  John C. Braisted ,  Noel T. Southall ,  Marc Ferrer ,  Christopher Dextras ,  John Haslam ,  Michael Baltezor

IPC分类号： A61K31/519 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/12 ,  A61P35/04

CPC分类号： A61K31/519 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/12 ,  A61P35/04

摘要： Disclosed are pharmaceutical formulations comprising a compound of formula (I):




in which R1, R2, R3, and R4 are as described herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for treating pancreatic adenocarcinoma comprising administration of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and methods of detecting the change in expression levels of one or both of FoxA1 and FoxO6 in a pancreatic adenocarcinoma tumor sample from a mammal, wherein the mammal has been administered a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240309102A1

公开(公告)日：2024-09-19

申请号：US18733957

申请日：2024-06-05

申请人： Lentigen Technology, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Rimas J. Orentas ,  Dina Schneider ,  Boro Dropulic ,  Dimiter S. Dimitrov ,  Zhong Zhu

IPC分类号： C07K16/28 ,  A61K35/17 ,  A61K38/00 ,  C07K14/705 ,  C07K14/725 ,  C12N15/10 ,  C12N15/86

CPC分类号： C07K16/2866 ,  A61K35/17 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C12N15/1037 ,  C12N15/86 ,  A61K38/00 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2740/15041

摘要： Chimeric antigen receptors containing CD123 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.

公开(公告)号：US12085569B2

公开(公告)日：2024-09-10

申请号：US17940883

申请日：2022-09-08

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Joshua LaBaer ,  Jie Wang ,  Ji Qiu ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC分类号： G01N33/574 ,  C07K16/30 ,  C12Q1/6886 ,  G01N33/564 ,  C12N15/11

CPC分类号： G01N33/57415 ,  C07K16/3015 ,  C12Q1/6886 ,  G01N33/564 ,  C12N15/11 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US20240287054A1

公开(公告)日：2024-08-29

申请号：US18568738

申请日：2022-06-09

申请人： The U.S.A., as Represented by the Secretary, Department of Health and Human Services

发明人： John S. Schneekloth ,  Mo Yang ,  Xiao Liang ,  Christopher Fullenkamp

IPC分类号： C07D413/14 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/55 ,  C07D413/04

CPC分类号： C07D413/14 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/55 ,  C07D413/04

摘要： Small molecule compounds that selectively bind to non-canonical G-quadruplex (G4) structures, such as G4s in DNA found in various types of genes described herein, along with methods of using the compounds to reduce or inhibit protein (e.g., N-Myc protein) expression in cells, such as cancer cells. The compounds have a structure according to formulas described herein, or a stereoisomer, tautomer, or pharmaceutically effective salt or ester thereof.

公开(公告)号：US12071634B2

公开(公告)日：2024-08-27

申请号：US17337978

申请日：2021-06-03

申请人： The USA, as represented by the Secretary, Department of Health and Human Services

发明人： Manfred Boehm ,  Guibin Chen ,  Mahendra Rao ,  Andre Larochelle

IPC分类号： C12N5/074 ,  C12N5/00 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0789

CPC分类号： C12N5/0607 ,  C12N5/0018 ,  C12N5/0647 ,  C12N5/0661 ,  C12N5/0662 ,  C12N5/0696 ,  C12N2500/05 ,  C12N2500/30 ,  C12N2500/36 ,  C12N2500/42 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/26 ,  C12N2506/03 ,  C12N2506/45

摘要： Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derided cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation.

公开(公告)号：US12071632B2

公开(公告)日：2024-08-27

申请号：US17049916

申请日：2019-04-23

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Shirin Munir ,  Linda G. Brock ,  Ursula J. Buchholz ,  Peter L. Collins

IPC分类号： C12N15/86 ,  A61K39/155 ,  A61P31/14 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K39/155 ,  A61P31/14 ,  A61K2039/5256 ,  A61K2039/543 ,  C12N2760/18534 ,  C12N2760/18544 ,  C12N2760/18551

摘要： Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.

公开(公告)号：US20240272191A1

公开(公告)日：2024-08-15

申请号：US18439795

申请日：2024-02-13

申请人： DH Technologies Development Pte. Ltd. ,  United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Meghav Verma ,  Samuel Michael ,  John Janiszewski ,  Chang Liu ,  Thomas R. Covey

IPC分类号： G01N35/10

CPC分类号： G01N35/1072 ,  G01N35/1011

摘要： A method of processing a sample plate containing a plurality of samples includes aspirating simultaneously, from the sample plate, a first sample droplet from a first sample of the plurality of samples with a first pipette and a second sample droplet from a second sample of the plurality of samples with a second pipette. The sample plate also includes dispensing sequentially, from the first pipette and the second pipette, the first sample drop and the second sample drop into an open port interface (OPI).

公开(公告)号：US12059413B2

公开(公告)日：2024-08-13

申请号：US16342695

申请日：2017-10-30

申请人： The Research Foundation for the State University of New York ,  THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services

发明人： Carol Carter ,  Lorna Erlich ,  Nico Tjandra ,  Madeleine Davison

IPC分类号： A61K31/4439 ,  G01N33/569

CPC分类号： A61K31/4439 ,  G01N33/56988

摘要： The present invention provides a method of inhibiting release of a virus from a cell, comprising contacting the cell with a compound that binds an ubiquitin E2 variant (UEV) domain of a cellular polypeptide, or fragment thereof, with an affinity sufficient to inhibit or disrupt the binding of the cellular polypeptide, or fragment thereof, to ubiquitin.

公开(公告)号：US12043660B2

公开(公告)日：2024-07-23

申请号：US17551066

申请日：2021-12-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Trustees of Columbia University in the City of New York

发明人： Peter Kwong ,  Young Do Kwon ,  Ivelin Georgiev ,  Gilad Ofek ,  Baoshan Zhang ,  Krisha McKee ,  John Mascola ,  Mark Connors ,  Gwo-Yu Chuang ,  Sijy O'Dell ,  Robert Bailer ,  Mark Louder ,  Mangaiarkarasi Asokan ,  Richard Schwartz ,  Jonathan Cooper ,  Kevin Carlton ,  Michael Bender ,  Amarendra Pegu ,  Lawrence Shapiro ,  Tatyana Gindin ,  Lisa Kueltzo

IPC分类号： C07K16/10 ,  A61P31/18

CPC分类号： C07K16/1063 ,  A61P31/18 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N2333/162

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.