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1.发明申请公开(公告)号：US20130200900A1
公开(公告)日：2013-08-08
申请号：US13879411
申请日：2011-10-04
Applicant: Johannes Buurman , Gregory Stanislaus Karczmar , Devkumar Mustafi , Bo Peng , Marko Kresimir Ivancevic , Marieke Heisen
Inventor： Johannes Buurman , Gregory Stanislaus Karczmar , Devkumar Mustafi , Bo Peng , Marko Kresimir Ivancevic , Marieke Heisen
IPC: G01R33/58
CPC classification number: G01R33/583 , G01R33/50 , G01R33/58
Abstract: Disclosed herein is a magnetic resonance imaging calibration assembly in particular, for dynamic contrast—enhanced magnetic resonance imaging. An exemplary magnetic resonance imaging calibration assembly according to the present disclosure can comprise a subject receptacle for receiving at least a portion of a subject. The exemplary magnetic resonance imaging calibration assembly can further comprise a plurality of phantom compartments, each of which can contain a calibration phantom with a predetermined known T relaxation time. The plurality of phantom compartments can be attached to the subject receptacle in different ways. For example, according to some exemplary embodiments of the 10 present invention, the phantom compartments are separate compartments attached or fixed onto the subject receptacle. According to other exemplary embodiments, the phantom compartments can be formed at least partially by the subject receptacle. The phantom can be for a T1 calibration making use of its known T1.
Abstract translation: 本文公开了一种磁共振成像校准组件，特别地用于动态对比度增强磁共振成像。 根据本公开的示例性磁共振成像校准组件可以包括用于接收对象的至少一部分的对象插座。 示例性磁共振成像校准组件还可以包括多个幻像室，每个幻像室可以包含具有预定已知T弛豫时间的校准体模。 多个幻影室可以以不同的方式附接到被摄体容器。 例如，根据本发明10的一些示例性实施例，幻影室是附接或固定到主体容器上的分离的隔室。 根据其他示例性实施例，幻影室可以至少部分地由主体容器形成。 幻影可以用于T1校准，使用其已知的T1。
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公开(公告)号：US08815557B2
公开(公告)日：2014-08-26
申请号：US11483898
申请日：2006-07-10
Applicant: Raphael C. Lee , Annie Kuo , Hanne Gissel Hyldkrog , Florin Despa , Devkumar Mustafi
Inventor： Raphael C. Lee , Annie Kuo , Hanne Gissel Hyldkrog , Florin Despa , Devkumar Mustafi
IPC: C12N9/00
CPC classification number: A01N1/0226 , C07K1/1136
Abstract: Compounds and methods for refolding of proteins in an aqueous solution. In particular, biocompatible multiblock copolymer surfactants such as poloxamers, meroxapols, poloxamines, or polyols are used to catalyze proper refolding without changing the protein composition, and restore the protein to its native conformation and native biological function. The methods can be practiced both in vivo and in vitro. The biocompatible multiblock copolymer surfactants can be used for renaturation of recombinantly expressed proteins, and for renaturation of proteins that are unfolded due to heat, irradiation, mechanical shearing, electrical shock, frostbite, chemical stress, and other abiotic or biotic stresses.
Abstract translation: 用于在水溶液中重折叠蛋白质的化合物和方法。 特别地，生物相容性多嵌段共聚物表面活性剂如泊洛沙姆，meroxapols，泊洛沙胺或多元醇用于催化正确的重折叠而不改变蛋白质组成，并将蛋白质恢复到其天然构象和天然生物学功能。 该方法可以在体内和体外实施。 生物相容性多嵌段共聚物表面活性剂可用于重组表达蛋白的复性，以及由于热，照射，机械剪切，电击，冻伤，化学应力和其他非生物或生物胁迫而展开的蛋白质的复性。
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公开(公告)号：US20070031955A1
公开(公告)日：2007-02-08
申请号：US11483898
申请日：2006-07-10
Applicant: Raphael Lee , Annie Kuo , Hanne Hyldkrog , Florin Despa , Devkumar Mustafi
Inventor： Raphael Lee , Annie Kuo , Hanne Hyldkrog , Florin Despa , Devkumar Mustafi
CPC classification number: A01N1/0226 , C07K1/1136
Abstract: Compounds and methods for refolding of proteins in an aqueous solution. In particular, biocompatible multiblock copolymer surfactants such as poloxamers, meroxapols, poloxamines, or polyols are used to catalyze proper refolding without changing the protein composition, and restore the protein to its native conformation and native biological function. The methods can be practiced both in vivo and in vitro. The biocompatible multiblock copolymer surfactants can be used for renaturation of recombinantly expressed proteins, and for renaturation of proteins that are unfolded due to heat, irradiation, mechanical shearing, electrical shock, frostbite, chemical stress, and other abiotic or biotic stresses.
Abstract translation: 用于在水溶液中重折叠蛋白质的化合物和方法。 特别地，生物相容性多嵌段共聚物表面活性剂如泊洛沙姆，meroxapols，泊洛沙胺或多元醇用于催化正确的重折叠而不改变蛋白质组成，并将蛋白质恢复到其天然构象和天然生物学功能。 该方法可以在体内和体外实施。 生物相容性多嵌段共聚物表面活性剂可用于重组表达蛋白的复性，以及由于热，照射，机械剪切，电击，冻伤，化学应力和其他非生物或生物胁迫而展开的蛋白质的复性。
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4.发明申请
公开(公告)号：US20100166662A1
公开(公告)日：2010-07-01
申请号：US12294649
申请日：2007-03-27
Applicant: Devkumar Mustafi , Gregory S. Karczmar , Marvin W. Makinen , Marta Zamora , Edward S. Foxley
Inventor： Devkumar Mustafi , Gregory S. Karczmar , Marvin W. Makinen , Marta Zamora , Edward S. Foxley
CPC classification number: A61K49/10
Abstract: A new, clinically applicable magnetic resonance imaging (MRI) method has been developed for in vivo imaging of a population of cells in a subject based on a class of paramagnetic divalent vanadyl-based contrast agents. The method includes administering to a subject a VO2+-based contrast agent and monitoring distribution of the VO2+-based contrast agent in the subject using magnetic resonance imaging.
Abstract translation: 已经开发了一种新的临床应用的磁共振成像（MRI）方法，用于基于一类顺磁二价氧钒基造影剂对受试者中的细胞群进行体内成像。 该方法包括向受试者施用基于VO2 +的造影剂并使用磁共振成像监测受试者中基于VO2 +的造影剂的分布。
