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20 条记录 (耗时 0.017 秒)

    Process for preparing acid salts of Gemifloxacin
    3.
    发明授权
    Process for preparing acid salts of Gemifloxacin 有权
    制备吉米沙星酸盐的方法

    公开(公告)号：US07361762B2

    公开(公告)日：2008-04-22

    申请号：US10510514

    申请日：2003-04-04

    申请人： Hoon Choi ,  Sang-Chul Choi ,  Do-Hyun Nam ,  Bo-Seung Choi

    发明人： Hoon Choi ,  Sang-Chul Choi ,  Do-Hyun Nam ,  Bo-Seung Choi

    IPC分类号： C07D221/02

    CPC分类号： C07D471/04

    摘要： The present invention relates to a process for preparing acid salts of Gemifloxacin, a quinolone type antibiotic agent having potent antimicrobial activity. The process according to the present invention can provide advantages such as simplicity of process, improvement of productivity and improvement of yield, and the like by reducing conventional three-step process to two-step process.

    摘要翻译： 本发明涉及一种制备具有强效抗菌活性的喹诺酮类抗生素的酸盐的方法。 根据本发明的方法可以通过将常规的三步骤过程减少到两步法来提供诸如方法的简单性，生产率的提高和产率的提高等的优点。

    Process for preparing acid salts of gemifloxacin
    4.
    发明申请
    Process for preparing acid salts of gemifloxacin 有权
    吉米沙星酸盐的制备方法

    公开(公告)号：US20050148622A1

    公开(公告)日：2005-07-07

    申请号：US10510514

    申请日：2003-04-04

    申请人： Hoon Choi ,  Sang-Chul Choi ,  Do-Hyun Nam ,  Bo-Seung Choi

    发明人： Hoon Choi ,  Sang-Chul Choi ,  Do-Hyun Nam ,  Bo-Seung Choi

    IPC分类号： A61K31/4745 ,  C07D20060101 ,  C07D471/02 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The present invention relates to a process for preparing acid salts of Gemifloxacin, a quinolone type antibiotic agent having potent antimicrobial activity. The process according to the present invention can provide advantages such as simplicity of process, improvement of productivity and improvement of yield, and the like by reducing conventional three-step process to two-step process.

    摘要翻译： 本发明涉及一种制备具有强效抗菌活性的喹诺酮类抗生素的酸盐的方法。 根据本发明的方法可以通过将常规的三步骤过程减少到两步法来提供诸如方法的简单性，生产率的提高和产率的提高等的优点。

    Method for proliferating stem cells by activating c-MET/HGF signaling and notch signaling
    7.
    发明授权
    Method for proliferating stem cells by activating c-MET/HGF signaling and notch signaling 有权
    通过激活c-MET / HGF信号传导和缺口信号传导来增殖干细胞的方法

    公开(公告)号：US08815581B2

    公开(公告)日：2014-08-26

    申请号：US13577092

    申请日：2011-02-01

    申请人： Do Hyun Nam ,  Seung Chyul Hong ,  Bong gu Kang ,  Kyeung Min Joo

    发明人： Do Hyun Nam ,  Seung Chyul Hong ,  Bong gu Kang ,  Kyeung Min Joo

    IPC分类号： C12N15/85 ,  C12N15/63 ,  C12N5/0797 ,  A61K35/30

    CPC分类号： C12N5/0623 ,  A61K35/30 ,  C12N15/86 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/12 ,  C12N2501/405 ,  C12N2501/42 ,  C12N2510/00

    摘要： The present invention relates to stem cells in which a gene that activates signaling is introduced and to a method for proliferating the stem cells. More specifically, the invention relates to a method of significantly increasing the ability of stem cells to proliferate, either by transfecting stem cells with the Notch intracellular domain (NICD) to activate the Notch signaling pathway, or by transfecting stem cells with the c-MET gene and treating the transfected stem cells with the HGF ligand protein to activate the c-MET/HGF signaling pathway. According to the present invention, as a result of activating the Notch signaling pathway or the c-MET/HGF signaling pathway, stem cells having an excellent ability to proliferate can be produced in large amounts. Particularly, since neural stem cells which have been difficult to culture in vitro can be proliferated in large amounts, thus the neural stem cells will be more useful for the preparation of cell therapeutic agents for treating cranial nerve diseases.

    摘要翻译： 本发明涉及其中引入了激活信号传导的基因的干细胞和涉及增殖干细胞的方法。 更具体地，本发明涉及通过用Notch细胞内结构域（NICD）转染干细胞以激活Notch信号传导途径或通过用c-MET转染干细胞来显着增加干细胞增殖能力的方法 并用HGF配体蛋白处理转染的干细胞以激活c-MET / HGF信号通路。 根据本发明，通过激活Notch信号传导途径或c-MET / HGF信号传导途径，可以大量产生具有优异增殖能力的干细胞。 特别是由于体外难以培养的神经干细胞可以大量增殖，因此神经干细胞将更有用于制备治疗颅神经疾病的细胞治疗剂。