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    Biomarkers of vulnerable atherosclerotic plaques and methods of use
    1.
    发明申请
    Biomarkers of vulnerable atherosclerotic plaques and methods of use 有权
    脆弱动脉粥样硬化斑块的生物标志物和使用方法

    公开(公告)号：US20070207507A1

    公开(公告)日：2007-09-06

    申请号：US11365127

    申请日：2006-02-28

    申请人： Young Kim ,  Ducksoo Kim ,  Mary Rusckowski

    发明人： Young Kim ,  Ducksoo Kim ,  Mary Rusckowski

    IPC分类号： G01N33/574 ,  A61K38/17 ,  C07K14/82 ,  C07K7/64 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/47 ,  C07K7/08 ,  C07K14/001 ,  G01N33/573 ,  G01N33/57484 ,  G01N2333/908

    摘要： The present invention provides compositions suitable for use as biomarkers of vulnerable plaques as well as methods for the use of such compositions. In preferred embodiments, specific molecular imaging agents are provided that permit the selective identification of vulnerable plaques in coronary and other arteries using non-invasive imaging methods. Such specific molecular imaging agents comprise a binding partner linked to a detectable label that can be used in vivo to visualize vulnerable plaques. In certain preferred embodiments, the binding partner is a peptide that binds selectively to a component of a vulnerable plaque. In other preferred embodiments, the binding partner is an antibody that binds selectively to a component of a vulnerable plaque. In other preferred embodiments, the binding partner is a portion of a polypeptide displayed by a bacteriophage that binds selectively to a component of a vulnerable plaque. In preferred embodiments, the component of a vulnerable plaque is myeloperoxidase or a portion thereof.

    摘要翻译： 本发明提供适合用作脆弱斑块生物标志物的组合物以及使用这种组合物的方法。 在优选的实施方案中，提供了允许使用非侵入性成像方法在冠状动脉和其他动脉中选择性鉴定易受伤害斑块的特定分子显像剂。 这样的特异性分子显像剂包含与可检测标记连接的结合配偶体，其可以在体内用于使脆弱的斑块可视化。 在某些优选的实施方案中，结合配偶体是选择性地结合易损斑块的组分的肽。 在其它优选的实施方案中，结合配偶体是选择性结合易损斑块组分的抗体。 在其它优选实施方案中，结合配偶体是通过噬菌体展示的多肽展示的部分，所述噬菌体选择性地结合易损斑块的成分。 在优选的实施方案中，脆性斑块的组分是髓过氧化物酶或其一部分。

    In-vivo method for repairing a ruptured segment of a therapeutic appliance surgically positioned previously within the body of a living human
    2.
    发明授权
    In-vivo method for repairing a ruptured segment of a therapeutic appliance surgically positioned previously within the body of a living human 失效
    用于修复先前位于活的人体内手术定位的治疗装置的破裂部分的体内方法

    公开(公告)号：US5653759A

    公开(公告)日：1997-08-05

    申请号：US503482

    申请日：1995-07-18

    申请人： John D. Hogan ,  Ducksoo Kim

    发明人： John D. Hogan ,  Ducksoo Kim

    IPC分类号： A61B17/00 ,  A61B17/88 ,  A61F2/00 ,  A61F2/01 ,  A61F2/82 ,  A61F2/02 ,  A61B17/56

    CPC分类号： A61B17/8863 ,  A61B2017/00292 ,  A61B2017/00867 ,  A61F2/01 ,  A61F2/82 ,  A61F2002/30093 ,  A61F2210/0019

    摘要： The present invention is an in-vivo methodology for repairing a ruptured or fragmented segment of a pre-existing therapeutic appliance which has been previously surgically positioned or implanted within the body of a living human. The repair methodology provides for specific apparatus and techniques using a guiding catheter and deformable, thermoelastic shape-memory alloy rods in order to access and repair the flawed or failing therapeutic appliance in place. The repair methodology thus eliminates the need for surgical excision procedures and avoids the requirement for replacement substitute units in order to alleviate and solve the problem of having a flawed therapeutic appliance in-vivo.

    摘要翻译： 本发明是用于修复预先存在的治疗器具的破裂或碎裂部分的体内方法，其已经被手术定位或植入活体的身体内。 修复方法提供了使用引导导管和可变形的热弹性形状记忆合金棒的特定装置和技术，以便访问和修复有缺陷或故障的治疗器具。 因此，修复方法消除了对外科切除手术的需要，并且避免了替换替代单元的需要，以便减轻和解决在体内具有缺陷治疗器具的问题。

    Self-contained power-assisted syringe
    3.
    发明授权
    Self-contained power-assisted syringe 有权
    独立的动力辅助注射器

    公开(公告)号：US07824373B2

    公开(公告)日：2010-11-02

    申请号：US10848714

    申请日：2004-05-19

    申请人： Ducksoo Kim ,  Joseph L. Smith, Jr. ,  James A. Crunkleton

    发明人： Ducksoo Kim ,  Joseph L. Smith, Jr. ,  James A. Crunkleton

    IPC分类号： A61M37/00

    CPC分类号： A61M5/2053 ,  A61M5/007 ,  A61M2205/581 ,  A61M2205/583

    摘要： A self-contained and hand-held power-assisted syringe is provided which is suitable for the controlled injection of fluid material during medical procedures such as coronary angiography procedures which utilize small-bore and small sized guide catheter systems. The present invention provides a greater degree of injection power on-demand than was previously possible in a portable and hand-held syringe; and it can deliver larger volumes of radiopaque contrast medium at greater pressures than was previously possible using a conventional manual syringe. The power assisted syringe, along with all components necessary for its effective use and operation, may be pre-packaged and steriled within a single container and then disposed of after use.

    摘要翻译： 提供了一种独立的手持式动力辅助注射器，其适用于在诸如使用小口径和小尺寸引导导管系统的冠状动脉造影术的医疗过程期间可控制地注射流体材料。 本发明提供比先前在便携式和手持式注射器中可能的更大程度的按需喷射功率; 并且它可以以比以前可能使用常规手动注射器更大的压力递送更大体积的不透射线造影剂。 动力辅助注射器以及其有效使用和操作所需的所有部件可以在单个容器内预先包装和灭菌，然后在使用后丢弃。

    Biomarkers of vulnerable atherosclerotic plaques and methods of use
    6.
    发明授权
    Biomarkers of vulnerable atherosclerotic plaques and methods of use 有权
    脆弱动脉粥样硬化斑块的生物标志物和使用方法

    公开(公告)号：US07560227B2

    公开(公告)日：2009-07-14

    申请号：US11365127

    申请日：2006-02-28

    申请人： Young H. Kim ,  Ducksoo Kim ,  Mary Rusckowski

    发明人： Young H. Kim ,  Ducksoo Kim ,  Mary Rusckowski

    IPC分类号： C12Q1/00 ,  C07K7/08 ,  C07K14/00

    CPC分类号： C07K14/47 ,  C07K7/08 ,  C07K14/001 ,  G01N33/573 ,  G01N33/57484 ,  G01N2333/908

    摘要： The present invention provides compositions suitable for use as biomarkers of vulnerable plaques as well as methods for the use of such compositions. In preferred embodiments, specific molecular imaging agents are provided that permit the selective identification of vulnerable plaques in coronary and other arteries using non-invasive imaging methods. Such specific molecular imaging agents comprise a binding partner linked to a detectable label that can be used in vivo to visualize vulnerable plaques. In certain preferred embodiments, the binding partner is a peptide that binds selectively to a component of a vulnerable plaque. In other preferred embodiments, the binding partner is an antibody that binds selectively to a component of a vulnerable plaque. In other preferred embodiments, the binding partner is a portion of a polypeptide displayed by a bacteriophage that binds selectively to a component of a vulnerable plaque. In preferred embodiments, the component of a vulnerable plaque is myeloperoxidase or a portion thereof.

    摘要翻译： 本发明提供适合用作脆弱斑块生物标志物的组合物以及使用这种组合物的方法。 在优选的实施方案中，提供了允许使用非侵入性成像方法在冠状动脉和其他动脉中选择性鉴定易受伤害斑块的特定分子显像剂。 这样的特异性分子显像剂包含与可检测标记连接的结合配偶体，其可以在体内用于使脆弱的斑块可视化。 在某些优选的实施方案中，结合配偶体是选择性地结合易损斑块的组分的肽。 在其它优选的实施方案中，结合配偶体是选择性结合易损斑块组分的抗体。 在其它优选实施方案中，结合配偶体是通过噬菌体展示的多肽展示的部分，所述噬菌体选择性地结合易损斑块的成分。 在优选的实施方案中，脆性斑块的组分是髓过氧化物酶或其一部分。

    Apparatus and method for closing a vascular perforation after percutaneous puncture of a blood vessel in a living subject
    7.
    发明授权
    Apparatus and method for closing a vascular perforation after percutaneous puncture of a blood vessel in a living subject 失效
    用于在活体受试者经皮穿刺血管之后闭合血管穿孔的装置和方法

    公开(公告)号：US5810884A

    公开(公告)日：1998-09-22

    申请号：US858890

    申请日：1997-05-19

    申请人： Ducksoo Kim

    发明人： Ducksoo Kim

    IPC分类号： A61B17/00 ,  A61B17/04

    CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00659

    摘要： The present invention provides unique apparatus, systems and methods for an aligned closing and stabilized sealing of a vascular perforation in a chosen blood vessel after percutaneous puncture and completion of a catheterization procedure. The invention is an adaptation of the conventionally known modified Seldinger technique in which the means for guidance, closing and stabilized sealing are deployed and positioned during the manipulations performed during the percutaneous puncture of the blood vessel itself.

    摘要翻译： 本发明提供了用于在经皮穿刺和完成导管插入术后所选择的血管中的血管穿孔的对齐闭合和稳定的密封的独特的装置，系统和方法。 本发明是常规已知的改进的Seldinger技术的改进，其中用于引导，关闭和稳定的密封的装置在血管本身的经皮穿刺期间进行的操作期间展开和定位。

    Self-contained power-assisted syringe
    9.
    发明授权
    Self-contained power-assisted syringe 失效
    独立的动力辅助注射器

    公开(公告)号：US08708958B2

    公开(公告)日：2014-04-29

    申请号：US12925434

    申请日：2010-10-22

    申请人： Ducksoo Kim ,  Joseph L. Smith, Jr. ,  James A. Crunkleton

    发明人： Ducksoo Kim ,  Joseph L. Smith, Jr. ,  James A. Crunkleton

    IPC分类号： A61M37/00

    CPC分类号： A61M5/2053 ,  A61M5/007 ,  A61M2205/581 ,  A61M2205/583

    摘要： A self-contained and hand-held power-assisted syringe is provided which is suitable for the controlled injection of fluid material during medical procedures such as coronary angiography procedures which utilize small-bore and small sized guide catheter systems. The present invention provides a greater degree of injection power on-demand than was previously possible in a portable and hand-held syringe; and it can deliver larger volumes of radiopaque contrast medium at greater pressures than was previously possible using a conventional manual syringe. The power assisted syringe, along with all components necessary for its effective use and operation, may be pre-packaged and steriled within a single container and then disposed of after use.

    摘要翻译： 提供了一种独立的手持式动力辅助注射器，其适用于在诸如使用小口径和小尺寸引导导管系统的冠状动脉造影术的医疗过程期间可控制地注射流体材料。 本发明提供比先前在便携式和手持式注射器中可能的更大程度的按需喷射功率; 并且它可以以比以前可能使用常规手动注射器更大的压力递送更大体积的不透射线造影剂。 动力辅助注射器以及其有效使用和操作所需的所有部件可以在单个容器内预先包装和灭菌，然后在使用后丢弃。

    Self-contained power-assisted syringe
    10.
    发明授权
    Self-contained power-assisted syringe 有权
    独立的动力辅助注射器

    公开(公告)号：US08480624B2

    公开(公告)日：2013-07-09

    申请号：US12925450

    申请日：2010-10-22

    申请人： Ducksoo Kim ,  Joseph L. Smith, Jr. ,  James A. Crunkleton

    发明人： Ducksoo Kim ,  Joseph L. Smith, Jr. ,  James A. Crunkleton

    IPC分类号： A61M37/00

    CPC分类号： A61M5/2053 ,  A61M5/007 ,  A61M2205/581 ,  A61M2205/583

    摘要： A self-contained and hand-held power-assisted syringe is provided which is suitable for the controlled injection of fluid material during medical procedures such as coronary angiography procedures which utilize small-bore and small sized guide catheter systems. The present invention provides a greater degree of injection power on-demand than was previously possible in a portable and hand-held syringe; and it can deliver larger volumes of radiopaque contrast medium at greater pressures than was previously possible using a conventional manual syringe. The power assisted syringe, along with all components necessary for its effective use and operation, may be pre-packaged and steriled within a single container and then disposed of after use.

    摘要翻译： 提供了一种独立的手持式动力辅助注射器，其适用于在诸如使用小口径和小尺寸引导导管系统的冠状动脉造影术的医疗过程期间可控制地注射流体材料。 本发明提供比先前在便携式和手持式注射器中可能的更大程度的按需喷射功率; 并且它可以以比以前可能使用常规手动注射器更大的压力递送更大体积的不透射线造影剂。 动力辅助注射器以及其有效使用和操作所需的所有部件可以在单个容器内预先包装和灭菌，然后在使用后丢弃。