公开(公告)号：US12237162B2

公开(公告)日：2025-02-25

申请号：US17371899

申请日：2021-07-09

Applicant: Duke University ,  Coldquanta, Inc.

Inventor： Jungsang Kim ,  Geert Vrijsen ,  Ismail Inlek ,  Tom Noel ,  Megan Ivory ,  Alexander Kato ,  Steve Hughes

IPC: H01J49/42 ,  H01J49/16 ,  H01J49/24

Abstract: Aspects of the present disclosure describe systems, methods, and structures that enable a compact, UHV ion trap system that can operate at temperatures above cryogenic temperatures. Ion trap systems in accordance with the present disclosure are surface treated and sealed while held in a UHV environment, where disparate components are joined via UHV seals, such as weld joints, compressible metal flanges, and UHV-compatible solder joints. As a result, no cryogenic pump is required, thereby enabling an extremely small-volume system.

公开(公告)号：US20250052763A1

公开(公告)日：2025-02-13

申请号：US18718238

申请日：2022-12-14

Applicant: Duke University

Inventor： Hiroaki Matsunami ,  Aashutosh Vihani

IPC: G01N33/68 ,  G16B15/30 ,  G16B35/00

Abstract: The present invention relates to compositions and methods for identifying odorant-odorant receptor interactions. In particular, the present invention relates to methods for identifying odorant receptor-odorant interactions based on odorant receptor amino acid sequence and other properties of odorant receptors and odorants. The methods provide, in part, for the broad surveying of OR responses, using an in vivo strategy, against a diverse panel of 10 odorants, followed by using the resulting interaction profiles to uncover relationships between OR responses, odorants, odor molecular properties, and OR sequences.

公开(公告)号：US20250027102A1

公开(公告)日：2025-01-23

申请号：US18757189

申请日：2024-06-27

Applicant: Duke University

Inventor： Sheng-Yang He ,  Jonghum Kim ,  Christian Danve M. Castroverde

IPC: C12N15/82 ,  C07K14/415 ,  G01N33/00

Abstract: The present disclosure describes, in part, compositions and methods for safeguarding plant immunity to pathogens in response to environmental changes.

公开(公告)号：US12186294B2

公开(公告)日：2025-01-07

申请号：US16780604

申请日：2020-02-03

Applicant: Duke University

Inventor： Tatjana Abaffy ,  Hiro Matsunami

IPC: A61K31/203 ,  A61K31/19 ,  A61K31/352 ,  A61K31/565 ,  A61K31/568 ,  A61K31/7016 ,  A61K47/06

Abstract: The present disclosure provides, in part, modulators of prostate-specific G-protein receptor (OR51E2/PSGR) and methods of treating, preventing, and diagnosing prostate cancer using the same.

公开(公告)号：US12173355B2

公开(公告)日：2024-12-24

申请号：US16809674

申请日：2020-03-05

Applicant: Duke University

Inventor： Tuan Vo-Dinh ,  Hsin-Neng Wang ,  Andrew Fales

IPC: C12Q1/68 ,  A61K31/713 ,  C12Q1/6825

Abstract: Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such that multiple targets can be detected simultaneously in a single sample. The methods of use of the nanoprobes include detection by a visible color change. The nanoprobes can be used in vivo for treatment of undesireable cells in a subject.

公开(公告)号：US20240409504A1

公开(公告)日：2024-12-12

申请号：US18812888

申请日：2024-08-22

Applicant: Duke University

Inventor： Dennis J. Thiele ,  Bushu Dong ,  Alexander M. Jaeger ,  Philip F. Hughes ,  Timothy Haystead ,  Jiyong Hong

IPC: C07C275/30 ,  A61P35/00 ,  C07C211/40 ,  C07C255/60 ,  C07C275/28 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C279/18 ,  C07C279/28 ,  C07C281/06 ,  C07C311/46 ,  C07C317/36 ,  C07C317/42 ,  C07D213/40 ,  C07D213/75 ,  C07D223/04 ,  C07D229/02 ,  C07D231/56 ,  C07D233/64 ,  C07D241/24 ,  C07D249/14 ,  C07D271/12 ,  C07D285/10 ,  C07D317/66 ,  C07D333/20 ,  C07D333/36 ,  C07D333/72 ,  C07D405/04 ,  C07D405/12 ,  C07D417/12

Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

公开(公告)号：US20240408244A1

公开(公告)日：2024-12-12

申请号：US18702693

申请日：2022-10-21

Applicant: Arizona Board of Regents on Behalf of the University of Arizona ,  Duke University

Inventor： Rui Chang ,  Roberta Diaz Brinton ,  Rima Kaddurah-Daouk

IPC: A61K49/00 ,  A61P25/28 ,  G01N33/68 ,  G01N33/92

Abstract: Provided herein are compositions and methods for diagnosing, prognosing, and treating neurodegenerative diseases in a male and female subject at risk of or diagnosed with a neurodegenerative disease. In particular, provided herein are customized metabolite analyses for characterizing and treating neurodegenerative diseases in specific subject groups from a sample from said subject.

公开(公告)号：US20240402164A1

公开(公告)日：2024-12-05

申请号：US18677255

申请日：2024-05-29

Applicant: Duke University

Inventor： Tuan Vo-Dinh ,  Aidan Canning

IPC: G01N33/543 ,  G01N33/53 ,  G01N33/531

Abstract: Methods are provided for making caged gold nanostars (C-GNSs). In one method, a layer of gold is deposited on the silver layer of bimetallic nanostar (BNS) particles in a galvanic replacement-free reaction and the silver is subsequently removed via hydrogen peroxide etching. In another method, gold ions are exchanged with the silver atoms of the BNS particles in a galvanic replacement reaction. Both methods result in a hollow gold shell around a gold nanostar core that enables loading with dyes for in vitro and in vivo detection of the C-GNSs and provides an internal standard in sensing. The C-GNS particles have a greater local electric field enhancement from the visible to the NIR spectral range relative to plasmonic-active GNSs of similar diameter that lack the hollow gold shell. Dye-loaded C-GNS particles are demonstrated for in vivo hyperspectral imaging and as photothermal transducers in the treatment of solid tumors.

公开(公告)号：US20240399360A1

公开(公告)日：2024-12-05

申请号：US18680164

申请日：2024-05-31

Applicant: Georgia Tech Research Corporation ,  Columbia University ,  The Jackson Laboratory ,  Imperial College London ,  Duke University

Inventor： Ross Ethier ,  Simon John ,  Krishnakumar Kizhatil ,  Darryl Overby ,  Seyed Mohammad Siadat ,  W. Daniel Stamer ,  Joseph van Batenburg-Sherwood

IPC: B01L3/00 ,  C12N5/00 ,  C12N5/071

Abstract: Disclosed herein is a biochip with a plurality of endothelial cells (e.g., Schlemm's canal cells) having a plurality of pores (e.g., transcellular pores) and methods of making and using the same.

公开(公告)号：US20240390392A1

公开(公告)日：2024-11-28

申请号：US18673022

申请日：2024-05-23

Applicant: Duke University

Inventor： Eric J. Benner

IPC: A61K31/575 ,  A61K35/20 ,  C12N5/079

Abstract: Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.