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公开(公告)号：US20240350606A1
公开(公告)日：2024-10-24
申请号：US18665046
申请日：2024-05-15
发明人： YOU-WEN HE , HEQIANG SUN , THOMAS AUGUST , JUN LIU , YADONG WEI
IPC分类号： A61K39/00 , A61K39/245 , A61P35/00 , C07K14/005 , C07K14/47 , C12N15/85
CPC分类号： A61K39/001192 , A61K39/0008 , A61K39/001104 , A61K39/001106 , A61K39/001109 , A61K39/001184 , A61K39/001186 , A61K39/245 , A61P35/00 , C07K14/005 , C07K14/4738 , C07K14/4748 , C12N15/85 , A61K2039/5154 , A61K2039/53 , A61K2039/585 , C07K2319/01 , C07K2319/02 , C07K2319/06 , C07K2319/40 , C12N2710/16134 , C12N2800/22 , C12N2840/203
摘要： Vaccine design, polycistronic vaccine constructs, compositions, and methods comprising nucleic acids (DNA, RNA), peptides, proteins and derivatives thereof, including cells and cell-lines, for enhanced antigen-specific vaccination.
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公开(公告)号：US20240342287A1
公开(公告)日：2024-10-17
申请号：US18751743
申请日：2024-06-24
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Harold WALDER , Frederic A. BOURKE, JR. , Zakaryae FATHI , Wayne F. BEYER , Mark OLDHAM , Justus ADAMSON , Michael NOLAN
CPC分类号： A61K41/0066 , A61K31/37 , A61N5/062 , A61N5/10 , A61K45/06 , A61N2005/0661 , A61N2005/1098
摘要： A kit for use in performing a cancer treatment, having a vial containing a phosphor-containing drug activator, wherein the phosphor-containing drug activator is present in the vial at a dosage level that is correlated with a size of tumor to be treated, and a container containing the vial;
wherein the phosphor-containing drug activator contains an admixture of two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays; where the two or more phosphors include Zn2SiO4:Mn2+ and (3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+) at a ratio (Zn2SiO4:Mn2+):(3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+)) of from 1:10 to 10:1; wherein each of the two or more phosphors have at least one coating selected from an ethyl cellulose coating and a diamond-like carbon coating.-
公开(公告)号：US20240342190A1
公开(公告)日：2024-10-17
申请号：US18633760
申请日：2024-04-12
IPC分类号： A61K31/555 , A01N1/02 , A61K9/00 , A61P9/10
CPC分类号： A61K31/555 , A01N1/0226 , A61K9/0019 , A61P9/10
摘要： Described herein is a method for reducing an ischemia-reperfusion injury in a subject, the method comprising intra-arterially administering a redox active compound that comprises a metal to the subject. Also described herein is a method for increasing the time of viability of an organ awaiting transplantation and/or reducing transplant failure in a subject, the method comprising contacting the organ and a redox active compound that comprises a metal.
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公开(公告)号：US12093788B2
公开(公告)日：2024-09-17
申请号：US17720955
申请日：2022-04-14
申请人： DUKE UNIVERSITY
发明人： Kenneth Brown , Mingyu Kang , Qiyao Liang , Bichen Zhang
摘要： The present disclosure describes techniques for optimizing two-qubit gates performance in a quantum circuit of a quantum computing system. A quantum computing system selects, from qubits in the quantum circuit, a pair of target qubits on which to perform a quantum gate operation. The quantum computing system selects, from the plurality of qubits, a second plurality of qubits on which to introduce an intentional noise. The intentional noise is applied to the second plurality of qubits via a numerical optimizer. An optimized frequency is determined based on the applied intentional noise. The quantum gate operation is performed by modifying the pair of target qubits frequency to the optimized frequency.
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公开(公告)号：US20240300837A1
公开(公告)日：2024-09-12
申请号：US18578262
申请日：2022-07-15
发明人： Shannon YEE , Dante DIMENICHI, III , Wiley D. HOLCOMBE , Jonathan HOLMES , Alexis NOEL , Kyle AZEVEDO , Ryan GAYLO , Stephanie RICHTER , Travis TURNER , Kristine SHERMAN , Brian HAWKINS , Graham MILLER , Lena TROTOCHAUD
IPC分类号： C02F11/122 , C02F11/13 , C02F11/18 , C02F103/00
CPC分类号： C02F11/122 , C02F11/13 , C02F11/185 , C02F2103/005 , C02F2209/02 , C02F2209/36 , C02F2209/44 , C02F2303/04
摘要： System and method for volume reduction solids treatment for fecal waste are described. The system can include a pasteurizer (102) configured to receive a slurry batch and heat the slurry batch at an elevated temperature for a time period to produce a pathogen free slurry. The system can also include a mechanical dewatering press (104) configured to compress the pathogen free slurry to separate a liquid phase from a volume reduced solid waste. The volume reduced solid waste being formed into a feces cake. The system can also include a means to remove the liquid phase and a drying tunnel (106) comprising a conveyor housed and an air duct system. The air duct system configured to propel forced air over the feces cake.
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公开(公告)号：US12084509B2
公开(公告)日：2024-09-10
申请号：US17245794
申请日：2021-04-30
申请人： Duke University
发明人： Eileen Chambers , Qing Cheng , Allan Kirk
IPC分类号： C07K16/28 , A61K31/573 , A61K45/06 , C12Q1/6876
CPC分类号： C07K16/2887 , A61K31/573 , A61K45/06 , C07K16/2809 , C07K16/2893 , C12Q1/6876
摘要： The present disclosure provides methods and compositions for detecting and treating acute transplant rejection.
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公开(公告)号：US12084480B2
公开(公告)日：2024-09-10
申请号：US17477192
申请日：2021-09-16
申请人： Duke University
发明人： Ashutosh Chilkoti , Nicholas Tang , Garrett Kelly
CPC分类号： C07K14/31 , A61K47/65 , G01N33/68 , A61K38/00 , C07K2319/02 , C07K2319/21 , G01N2800/52
摘要： Described herein are unstructured polypeptides lacking any discernible repeat motif. Also described herein are fusion proteins including at least one of the unstructured polypeptides and at least one binding polypeptide. Further described are methods for treating a disease in a subject in need thereof. The methods may include administering to the subject an effective amount of the fusion protein.
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8.发明公开公开(公告)号：US20240294576A1
公开(公告)日：2024-09-05
申请号：US17919997
申请日：2021-05-05
申请人： DUKE UNIVERSITY
IPC分类号： C07K14/005 , A61K38/46 , A61K47/64 , C12N15/86
CPC分类号： C07K14/005 , A61K38/465 , A61K47/64 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152
摘要： Disclosed herein are compositions and methods for enhancing secretion of extracellular vesicles and/or AAV particles from cells. Disclosed herein are compositions and methods for altering and/or modifying the formation and/or secretion of extracellular vesicles and/or AAV particles from cells. Disclosed herein are compositions and methods for loading extracellular vesicles and or AAV particles with a cargo. Disclosed herein are isolated nucleic acid molecules encoding a polypeptide for promoting the formation of extracellular vesicles and AAV particles in cell or a polypeptide associated with extracellular vesicles and/or AAV particles secreted from a cell.
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公开(公告)号：US20240279657A1
公开(公告)日：2024-08-22
申请号：US18570967
申请日：2022-06-16
申请人： Duke University
IPC分类号： C12N15/113 , A61K31/7115 , A61P7/00
CPC分类号： C12N15/113 , A61K31/7115 , A61P7/00
摘要： The present disclosure describes, in part, compositions and method for the prevention and treatment of hemoglobinopathies, including sickle cell disease by inhibition or decreasing production, expression or activity of Rpl13 snoRNAs.
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公开(公告)号：US20240279234A1
公开(公告)日：2024-08-22
申请号：US18644865
申请日：2024-04-24
发明人： Timothy A.J. Haystead , David A. Carlson , Douglas H. Weitzel , Justin A. MacDonald , Michael P. Walsh
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as PIM kinases. The compounds can be used in methods of treating various disorders, including cancers.
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