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    Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
    4.
    发明授权
    Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same 有权
    制备用于治疗和诊断应用的多价构建体的方法及其制备方法

    公开(公告)号：US07666979B2

    公开(公告)日：2010-02-23

    申请号：US10916155

    申请日：2004-08-11

    申请人： Hong Fan ,  Edmund R. Marinelli ,  Palaniappa Nanjappan ,  Radhakrishna Pillai ,  Rolf E. Swenson

    发明人： Hong Fan ,  Edmund R. Marinelli ,  Palaniappa Nanjappan ,  Radhakrishna Pillai ,  Rolf E. Swenson

    IPC分类号： C07K4/00 ,  C07K1/00

    CPC分类号： A61K51/088 ,  A61K47/60 ,  A61K47/64 ,  A61K49/0043 ,  A61K49/0056 ,  A61K49/223 ,  B82Y5/00 ,  C07K7/08 ,  C07K7/64

    摘要： Methods for the preparation of multivalent constructs for therapeutic and diagnostic applications are provided. More specifically, novel methods for preparing multivalent constructs comprising the formula A-B-C-D-E-B′-F for therapeutic and diagnostic applications are provided which use a novel linker D comprising, in various embodiments, a dicarboxylic acid derivative such as, e.g., a glutaric acid bis N-hydroxysuccinimidyl ester or a derivative thereof; or a diamine derivative.The remaining components in the multivalent construct A-B-C-D-E-B′-F are defined as follows: A is a first peptide, B is a first branching group, C is an optional first spacer, E is an optional second spacer which may be the same as or different from said first spacer C, B′ is an optional second branching group which may be the same as or different from said first branching group B, and F is a second peptide which may be the same as or different from said first peptide A.

    摘要翻译： 提供了用于治疗和诊断应用的多价构建体的制备方法。 更具体地，提供了用于制备包含用于治疗和诊断应用的式ABCDEB'-F的多价构建体的新方法，其使用新的接头D，其在各种实施方案中包括二羧酸衍生物，例如戊二酸双-N- 羟基琥珀酰亚胺酯或其衍生物; 或二胺衍生物。 多价构建体ABCDEB'-F中的其余组分定义如下：A是第一个肽，B是第一个支化基团，C是可选的第一个间隔基，E是可选的第二间隔基，其可以相同或不同 从所述第一间隔物C中，B'是任选的第二支化基团，其可以与所述第一支化基团B相同或不同，F是可以与所述第一肽A相同或不同的第二肽。